KLHL2 (NM_001161521) Human Untagged Clone

CAT#: SC327117

KLHL2 (untagged)-Human kelch-like 2 Mayven (Drosophila) (KLHL2) transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KLHL2
• Synonyms: ABP-KELCH; MAV; MAYVEN
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001161521, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGTATGGTTGGAAGCACGGCCCCAGATTCTCTTTGTATGCACAAAGCAGGGTCATCAGAAGCCTCTCG
  ATTCAAAAGATGATAATACCGAAAAACACTGCCCAGTGACAGTGAATCCTTGGCATATGAAGAAAGCTTT
  CAAAGTCATGAACGAATTAAGAAGTCAAAATTTGCTGTGCGATGTCACAATTGTGGCAGAAGACATGGAA
  ATTTCTGCTCATAGAGTGGTGCTGGCCGCCTGTAGTCCTTATTTTCATGCCATGTTTACAGGTGAGATGA
  GTGAGAGCCGAGCAAAGAGAGTTAGAATAAAAGAGGTAGATGGCTGGACCCTGAGGATGCTAATTGATTA
  TGTTTACACTGCAGAAATTCAGGTTACAGAAGAAAATGTACAGGTACTTCTCCCAGCAGCTGGTCTCTTA
  CAGTTACAGGATGTGAAGAAGACTTGTTGTGAATTTTTGGAATCCCAGCTTCACCCTGTCAACTGCTTAG
  GAATCCGGGCTTTTGCTGATATGCATGCATGTACCGACCTTCTGAACAAGGCCAACACCTATGCAGAGCA
  ACATTTTGCAGATGTTGTACTTAGTGAAGAATTTCTCAATCTTGGCATCGAACAAGTGTGCAGCTTAATC
  TCAAGTGACAAACTTACCATTTCTTCAGAAGAGAAGGTATTTGAAGCAGTAATAGCATGGGTGAACCATG
  ACAAGGATGTGAGGCAAGAGTTTATGGCCCGACTGATGGAACATGTACGGTTACCTTTGCTTCCTCGGGA
  ATATTTAGTTCAGAGGGTTGAAGAGGAAGCATTGGTCAAGAATAGCAGTGCTTGCAAAGATTACCTCATT
  GAAGCAATGAAGTACCATTTGCTGCCAACAGAGCAGCGTATATTAATGAAGAGTGTCCGGACCCGGCTGA
  GGACACCCATGAACCTTCCCAAATTGATGGTGGTGGTTGGGGGCCAAGCACCAAAGGCTATCCGGAGTGT
  GGAATGCTATGACTTTAAAGAAGAAAGGTGGCACCAAGTAGCAGAGTTGCCTTCCAGGAGGTGCAGGGCA
  GGCATGGTCTACATGGCTGGACTTGTTTTTGCTGTTGGTGGCTTTAATGGCTCATTAAGAGTTCGCACTG
  TAGATTCCTACGACCCTGTGAAGGACCAGTGGACCAGCGTTGCTAACATGAGAGACCGGAGAAGCACTTT
  GGGAGCTGCTGTGTTAAATGGATTATTATACGCTGTGGGAGGCTTTGATGGGAGTACAGGTTTGTCATCT
  GTGGAAGCATACAACATAAAGTCTAATGAGTGGTTTCATGTAGCTCCCATGAATACAAGGAGGAGCAGTG
  TTGGTGTGGGTGTTGTTGGAGGTTTGCTCTATGCTGTAGGAGGTTATGATGGAGCATCACGTCAGTGTCT
  TAGCACAGTAGAATGCTATAATGCTACAACAAATGAGTGGACCTATATAGCAGAAATGAGCACCAGGCGG
  AGTGGAGCAGGTGTTGGTGTGTTAAACAATTTATTGTATGCTGTAGGAGGTCATGATGGCCCTTTAGTAC
  GAAAAAGTGTTGAAGTATATGATCCCACCACTAACGCATGGAGACAGGTTGCAGATATGAACATGTGCAG
  AAGAAATGCAGGAGTTTGTGCAGTTAATGGTCTGTTATATGTTGTTGGAGGGGATGATGGTTCCTGTAAC
  TTGGCGTCAGTAGAATATTATAACCCAACAACCGATAAATGGACAGTTGTGTCATCGTGTATGAGCACAG
  GGAGAAGTTATGCAGGGGTCACAGTTATTGATAAACCATTATGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001161521
• ORF Size: 1794 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001161521.1, NP_001154993.1
• RefSeq Size: 3014
• RefSeq ORF: 1794
• Locus ID: 11275
• Gene Summary: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.