ALOXE3 (NM_001165960) Human Untagged Clone

CAT#: SC327230

ALOXE3 (untagged)-Human arachidonate lipoxygenase 3 (ALOXE3) transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ALOXE3
• Synonyms: ARCI3; E-LOX; eLOX-3; eLOX3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001165960, the custom clone sequence may differ by one or more nucleotides
  ATGCCACGCGGGGCATTCAGACCCTGTTTGCCGGCGCTGTATTTCGCTTTCCTGACCTGC
  CCTACTCCAGAGCAGAGAATGAGTGGAACCCAGGCTCCTGATATCCATCTGGGTGAGCCA
  GCCAGAGGGACCGGCTGTGTCAGAGGCAAGCAAACAAGTATTAGAGTGCAAGACTGTGGG
  CGGAGAGAGGAAGCCCGAGCCGCCAGCAGGGAGCTTCGGAGAGAGAAAGCCCAGGAACAT
  CCCAGAGAGAGCTGGGCCCATCCTCAGCCCTACCCAGCCCCGCAGCCCCTAGCCCTCCGC
  CCAGAAACCCAGCCCTGTCCGGCGTGCCGCTCTTCTCCTCCAGGCCGGCTGCTGCTGCGG
  CCAGCGTTGCCGGGGCATCCCTTCCTCCTTCCCATCATGGCAGTGTACCGCCTGTGTGTG
  ACCACTGGTCCCTACCTGAGGGCCGGCACACTGGACAACATCTCTGTCACACTGGTGGGC
  ACGTGTGGTGAAAGCCCCAAGCAGCGGCTAGATCGAATGGGCAGGGACTTCGCCCCTGGA
  TCGGTACAGAAGTACAAGGTGCGTTGCACAGCGGAGCTGGGTGAGCTCTTGCTGCTGCGT
  GTACACAAGGAGCGCTACGCTTTCTTCCGCAAGGACTCTTGGTACTGTAGCCGCATCTGT
  GTCACCGAACCGGATGGTAGTGTATCCCACTTCCCCTGCTATCAGTGGATTGAAGGCTAC
  TGCACCGTGGAGCTGAGGCCAGGAACAGCAAGAACTATTTGTCAGGACTCTCTTCCCCTC
  CTCCTGGATCACAGGACACGGGAGCTCCGGGCCCGACAAGAATGCTACCGCTGGAAGATC
  TATGCCCCTGGCTTCCCCTGCATGGTAGACGTCAACAGCTTTCAGGAGATGGAGTCAGAC
  AAGAAATTTGCCTTGACAAAGACGACAACTTGTGTAGACCAGGGTGACAGCAGTGGGAAT
  CGGTACCTGCCCGGCTTCCCCATGAAAATTGACATCCCATCCCTGATGTACATGGAGCCC
  AATGTTCGATACTCAGCCACCAAGACGATCTCGCTGCTCTTCAATGCCATCCCTGCGTCC
  TTGGGAATGAAGCTTCGAGGGCTGTTGGATCGCAAGGGCTCCTGGAAGAAGCTGGATGAC
  ATGCAGAACATCTTCTGGTGCCATAAGACCTTCACGACAAAGTATGTCACAGAGCACTGG
  TGTGAAGATCACTTCTTTGGGTACCAGTACCTGAATGGTGTCAATCCCGTCATGCTCCAC
  TGCATCTCTAGCTTGCCCAGCAAGCTGCCTGTCACCAATGACATGGTGGCCCCCTTGCTG
  GGACAGGACACATGCCTGCAGACAGAGCTAGAGAGGGGGAACATCTTCCTAGCGGACTAC
  TGGATCCTGGCGGAGGCCCCCACCCACTGCCTAAACGGCCGCCAGCAGTACGTGGCCGCC
  CCACTGTGCCTGCTGTGGCTCAGCCCCCAGGGGGCGCTGGTGCCCTTGGCCATCCAGCTC
  AGCCAGACCCCCGGGCCTGACAGCCCCATCTTCCTGCCCACTGACTCCGAATGGGACTGG
  CTGCTGGCCAAGACGTGGGTGCGCAACTCTGAGTTCCTGGTGCACGAAAACAACACGCAC
  TTTCTGTGCACGCATTTGCTGTGCGAGGCCTTCGCCATGGCCACGCTGCGCCAGCTGCCG
  CTCTGCCACCCCATCTACAAGCTCCTACTCCCCCACACTCGATACACGCTGCAGGTGAAC
  ACCATCGCGAGGGCCACGCTGCTCAACCCCGAGGGCCTCGTGGACCAGGTCACGTCCATC
  GGGAGGCAAGGCCTCATCTACCTCATGAGCACGGGCCTGGCCCACTTCACCTACACCAAT
  TTCTGCCTTCCGGACAGCCTGCGGGCCCGCGGCGTCCTGGCTATCCCCAACTACCACTAC
  CGAGACGACGGCCTGAAGATCTGGGCGGCCATTGAGAGCTTTGTCTCAGAAATCGTGGGC
  TACTATTATCCCAGTGACGCATCTGTGCAGCAGGATTCGGAGCTGCAGGCCTGGACTGGC
  GAGATTTTTGCTCAGGCGTTCCTGGGCCGGGAAAGCTCAGGTTTCCCAAGCCGGCTGTGC
  ACCCCAGGAGAGATGGTGAAGTTCCTCACTGCAATCATCTTCAATTGCTCTGCCCAGCAC
  GCTGCTGTCAACAGTGGGCAGCATGACTTTGGGGCCTGGATGCCCAATGCTCCATCATCC
  ATGAGGCAGCCCCCACCCCAGACCAAGGGGACCACCACCCTGAAGACTTACCTAGACACC
  CTCCCTGAAGTGAACATCAGCTGTAACAACCTCCTCCTCTTCTGGTTGGTTAGCCAAGAA
  CCCAAGGACCAGAGGCCCCTGGGCACCTACCCAGATGAGCACTTCACAGAGGAGGCCCCG
  AGGCGGAGCATCGCCGCCTTCCAGAGCCGCCTGGCCCAGATCTCAAGGGACATCCAGGAG
  CGGAACCAGGGTCTGGCACTGCCCTACACCTACCTGGACCCTCCCCTCATTGAGAACAGC
  GTCTCCATC
  
• Restriction Sites: Please inquire
• ACCN: NM_001165960
• ORF Size: 2532 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001165960.1, NP_001159432.1
• RefSeq Size: 3415
• RefSeq ORF: 2532
• Locus ID: 59344
• Protein Families: Druggable Genome
• Gene Summary: This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).