Phospholipase C epsilon 1 (PLCE1) (NM_001165979) Human Untagged Clone

CAT#: SC327342

PLCE1 (untagged)-Human phospholipase C epsilon 1 (PLCE1) transcript variant 2


  "NM_001165979" in other vectors (2)

Reconstitution Protocol

USD 4,050.00

7 Weeks*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PLCE1
Synonyms NPHS3; PLCE; PPLC
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_001165979, the custom clone sequence may differ by one or more nucleotides
ATGGTTTCAGAAGGAAGTGCAGCAGGAAGAGACTTTGCAGGAATGGAAGAGGTGAGGCAG
CTCCACGTGAGATTCTGCAAAGGGATTAAGATTTGGCACCAGGCTTGGTTTCTGTGCAGC
CTCTTAGGCAGAGAGCCCCAGGAGAGGGAAGCAGGCTGTCAGCTGTGGCTTTGCACGCTC
TCAGCTGTCTTGAAGGTTGGTTGGCTCTTCCCGCTCTCTGAGGTACCCAATTTTACCTTG
TTAAAGGATGGATGTGGATGCTGGAGGCTTAAAGAAGACCAGATCTACAATGCAGTGAGA
AGAGAAGAAACAGAAAATACAGTTGGATCTCTACTCCATTTCCTCACCAAGCTCCCAGCC
TCCGAGACAGCCCATGGAAGGATAAGCGTTGGTCCATGCTTAAAGCAATGTGTCCGAGAC
ACTGTATGTGAGTATCGCGCCACCCTCCAAAGGACTTCAATATCGCAGTACATCACCGGT
TCTCTCCTAGAAGCAACCACGTCTTTGGGAGCAAGAAGTGGCCTTCTCAGTACTTTTGGA
GGATCCACTGGACGAATGATGCTGAAAGAACGCCAGCCAGGCCCCTCTGTGGCCAATTCC
AATGCCCTCCCTTCAAGTTCAGCTGGGATCAGCAAGGAGCTGATCGATCTGCAGCCTCTC
ATCCAGTTCCCAGAGGAAGTCGCCAGCATCCTGATGGAGCAAGAGCAGACTATTTACCGC
AGGGTCTTGCCAGTCGACTACCTTTGCTTCTTAACACGGGACTTGGGCACTCCTGAATGC
CAGAGCTCCTTGCCCTGCCTCAAAGCATCCATCTCAGCGTCGATTCTTACCACTCAGAAT
GGAGAGCACAATGCCCTTGAAGATCTGGTGATGAGGTTTAATGAGGTGAGCTCCTGGGTG
ACATGGCTGATCCTCACGGCAGGCTCCATGGAGGAGAAGCGAGAAGTCTTTTCATATTTG
GTGCATGTGGCCAAATGCTGCTGGAACATGGGCAACTACAACGCTGTCATGGAGTTCTTG
GCTGGCCTCAGGTCAAGAAAAGTTTTAAAAATGTGGCAGTTCATGGACCAGTCTGATATT
GAGACCATGAGGAGCCTGAAGGATGCTATGGCCCAGCATGAGTCCTCTTGTGAGTACAGA
AAGGTGGTGACACGTGCCCTGCACATCCCTGGCTGTAAGGTGGTTCCATTCTGTGGGGTG
TTTCTGAAGGAGCTCTGTGAAGTGCTTGACGGCGCCTCCGGTCTCATGAAGCTTTGCCCG
CGGTACAATTCCCAAGAAGAAACTTTAGAGTTTGTAGCAGATTACAGTGGACAAGATAAT
TTCTTACAACGAGTGGGACAAAATGGCTTAAAGAATTCGGAGAAGGAGTCCACTGTCAAC
AGCATCTTTCAGGTCATCCGGAGCTGCAATCGAAGTCTGGAGACAGACGAGGAGGACAGC
CCCAGTGAAGGAAACAGCTCCAGGAAAAGCTCCTTGAAGGATAAAAGCCGATGGCAGTTT
ATAATTGGAGATTTGTTGGATTCAGACAATGACATCTTTGAGCAATCCAAAGAATACGAC
TCTCATGGTTCAGAGGACTCACAGAAGGCCTTCGACCATGGGACGGAGCTCATCCCTTGG
TACGTGCTGTCCATCCAAGCCGATGTGCACCAGTTCCTGCTGCAGGGGGCCACGGTCATC
CACTACGACCAGGACACACACCTCTCTGCCCGCTGCTTCCTCCAGCTTCAGCCCGACAAT
AGCACCTTGACCTGGGTAAAGCCCACAACTGCCTCCCCAGCCAGCAGTAAAGCAAAACTT
GGTGTACTTAATAACACAGCTGAGCCTGGAAAATTCCCACTACTGGGTAATGCTGGATTA
AGTAGCCTGACGGAAGGGGTCTTGGATCTTTTTGCAGTGAAGGCTGTATACATGGGCCAC
CCTGGCATTGATATACACACTGTGTGTGTTCAGAACAAACTGGGTAGCATGTTCCTGTCA
GAGACTGGTGTGACATTGCTCTATGGGCTTCAGACCACAGACAACAGATTATTGCACTTC
GTGGCACCAAAGCACACAGCTAAAATGCTCTTCAGCGGATTATTGGAACTCACTAGAGCT
GTGAGAAAGATGAGGAAATTCCCTGACCAAAGACAGCAGTGGCTGCGGAAACAGTACGTC
AGCCTTTATCAGGAGGATGGACGGTATGAAGGCCCAACTTTGGCTCACGCTGTGGAGTTG
TTTGGTGGCAGACGGTGGAGTGCTCGAAACCCCAGCCCCGGAACATCAGCAAAGAATGCT
GAGAAGCCCAATATGCAGAGAAACAATACCCTGGGCATAAGCACTACCAAGAAAAAGAAG
AAAATCCTCATGAGGGGTGAGAGTGGAGAGGTAACTGACGATGAGATGGCAACCCGAAAG
GCCAAGATGCACAAAGAGTGTCGAAGCCGGAGTGGTTCTGATCCTCAAGACATTAATGAA
CAAGAAGAATCAGAGGTGAATGCCATCGCTAACCCTCCAAACCCCCTCCCTTCCAGAAGA
GCCCACTCTTTGACCACAGCTGGGTCCCCCAACTTGGCTGCCGGGACGTCATCTCCCATC
AGGCCAGTGTCCTCCCCTGTGCTGTCTTCTTCAAACAAGAGCCCATCCAGTGCTTGGAGC
AGTAGTAGCTGGCACGGGCGGATCAAAGGCGGCATGAAGGGATTTCAGAGCTTCATGGTT
TCAGATAGCAACATGAGTTTTGTTGAATTTGTTGAGCTGTTCAAATCATTCAGTGTCAGG
AGCCGCAAGGACCTGAAGGATCTGTTTGATGTCTATGCAGTGCCCTGCAACCGATCTGGC
TCCGAGTCAGCCCCACTCTACACCAACCTGACAATTGATGAAAACACCAGCGATCTTCAG
CCTGACCTAGATCTGTTGACCAGAAATGTCTCGGATTTGGGGTTGTTCATTAAGAGTAAA
CAGCAGCTATCGGACAACCAGAGGCAGATATCTGATGCCATTGCTGCTGCAAGCATTGTG
ACAAATGGCACTGGGATTGAGAGCACATCTCTGGGCATTTTTGGGGTGGGCATACTTCAG
CTCAACGATTTCCTCGTGAATTGCCAAGGAGAACACTGCACTTATGATGAAATCCTCAGC
ATCATCCAGAAGTTCGAGCCTAGCATCAGTATGTGTCATCAGGGACTAATGTCATTTGAA
GGGTTTGCCAGGTTTCTGATGGATAAAGAAAATTTTGCCTCAAAAAATGATGAGTCACAG
GAGAACATTAAAGAACTGCAGCTACCCCTCTCATACTATTACATCGAATCTTCGCACAAT
ACCTACCTCACGGGCCATCAGCTCAAAGGAGAATCCTCGGTAGAACTCTACAGCCAGGTC
CTTTTGCAAGGCTGTCGAAGTGTAGAATTGGACTGCTGGGACGGAGACGATGGGATGCCC
ATCATTTATCATGGACATACGCTGACAACCAAGATCCCCTTCAAGGAAGTGGTTGAAGCC
ATTGATCGCAGTGCCTTCATCAACTCTGACCTGCCAATCATCATATCGATTGAGAACCAC
TGTTCATTGCCTCAGCAACGAAAAATGGCAGAAATTTTCAAGACTGTGTTTGGAGAAAAG
CTGGTGACTAAATTCTTATTTGAGACTGATTTCTCAGATGATCCAATGCTTCCTTCACCT
GACCAACTCAGAAAGAAAGTTCTTCTTAAAAACAAGAAGCTAAAAGCCCATCAGACGCCA
GTGGATATCTTAAAGCAAAAGGCTCATCAGTTAGCATCTATGCAAGTGCAGGCTTATAAT
GGTGGGAATGCCAACCCCCGACCTGCCAATAATGAGGAAGAGGAAGATGAGGAGGACGAA
TATGATTATGACTATGAATCCCTTTCTGATGACAACATTCTGGAAGACAGACCTGAAAAT
AAATCATGTAATGACAAGCTTCAGTTTGAATATAATGAAGAAATCCCAAAGAGGATAAAG
AAAGCAGATAACTCTGCTTGCAACAAAGGAAAGGTTTATGATATGGAACTGGGAGAAGAA
TTTTATCTTGATCAGAATAAAAAGGAAAGCAGACAGATTGCACCAGAGCTTTCTGACCTT
GTAATCTATTGTCAAGCAGTAAAATTTCCAGGACTGTCAACTCTAAATGCATCTGGCTCT
AGCAGAGGAAAAGAAAGGAAAAGCAGGAAGTCCATTTTTGGCAACAATCCGGGCAGAATG
AGCCCAGGGGAGACAGCATCATTTAACAAAACATCTGGAAAAAGTTCCTGTGAAGGCATT
CGACAGACCTGGGAGGAATCTTCTTCCCCTCTCAACCCAACCACGTCCCTCAGTGCTATC
ATTAGAACTCCCAAATGTTATCATATCTCGTCGCTGAATGAAAATGCCGCCAAACGTCTG
TGTCGCAGGTATTCTCAGAAACTGACCCAGCACACCGCCTGTCAGCTGCTGAGAACTTAC
CCTGCTGCCACCCGCATCGACTCTTCCAACCCGAACCCCCTCATGTTCTGGCTCCATGGG
ATACAGCTTGTGGCACTCAACTACCAGACTGATGATCTCCCTTTACATTTAAATGCTGCA
ATGTTTGAGGCAAATGGTGGTTGTGGTTATGTATTGAAACCTCCAGTTCTGTGGGACAAG
AACTGCCCCATGTATCAGAAGTTTTCTCCACTAGAAAGAGATCTGGACAGCATGGATCCT
GCAGTCTATTCTTTAACTATTGTCTCTGGTCAGAATGTGTGCCCCAGTAATAGCATGGGA
AGCCCGTGCATTGAAGTCGACGTCCTGGGCATGCCTCTGGACAGCTGCCATTTCCGCACA
AAGCCCATCCATCGAAACACCCTGAACCCCATGTGGAACGAGCAGTTTCTGTTCCACGTT
CACTTCGAAGATCTTGTATTTCTTCGTTTTGCAGTTGTGGAAAACAATAGTTCAGCGGTA
ACTGCTCAGAGAATCATTCCACTGAAAGCTTTAAAACGAGGATATCGACATCTTCAGCTG
CGAAACCTTCACAATGAAGTCTTGGAGATTTCTAGTTTATTCATTAACAGCAGAAGGATG
GAAGAAAATTCCTCTGGCAATACCATGTCAGCCTCTTCGATGTTTAATACAGAAGAAAGA
AAATGTTTGCAGACTCACAGAGTCACGGTGCATGGGGTCCCAGGGCCAGAGCCCTTTACC
GTTTTCACTATTAATGGAGGCACCAAGGCAAAGCAGCTTCTGCAGCAAATTCTGACAAAT
GAACAAGACATCAAACCTGTTACCACAGACTATTTTTTGATGGAAGAAAAATATTTTATA
TCTAAAGAAAAGAATGAATGTAGGAAACAACCATTCCAGAGAGCCATTGGTCCAGAAGAG
GAGATCATGCAAATTTTAAGCAGCTGGTTTCCAGAAGAGGGATACATGGGCAGGATTGTC
TTAAAAACCCAGCAGGAAAACCTAGAAGAGAAAAACATTGTTCAAGATGACAAAGAGGTG
ATCTTGAGCTCAGAGGAGGAGAGTTTCTTTGTCCAAGTGCATGATGTTTCTCCAGAGCAA
CCTCGAACAGTCATCAAAGCACCCCGCGTCAGCACTGCACAGGATGTCATTCAGCAGACC
TTATGCAAAGCCAAATATTCCTACAGCATCCTGAGCAACCCCAATCCAAGCGACTATGTG
CTTTTGGAAGAGGTGGTGAAAGACACTACCAACAAGAAGACTACCACACCAAAGTCCTCT
CAGCGGGTCCTTCTGGATCAGGAGTGTGTGTTTCAAGCCCAAAGCAAGTGGAAAGGTGCA
GGAAAATTCATCCTTAAGCTAAAGGAGCAGGTGCAGGCATCTCGAGAAGATAAAAAGAAA
GGCATTTCTTTCGCAAGTGAACTCAAGAAGCTCACCAAGTCAACTAAACAGCCCCGAGGA
CTTACATCACCTTCTCAGCTCTTGACCTCAGAAAGTATCCAAACCAAGGAGGAGAAACCT
GTGGGTGGCTTGTCCTCCAGTGACACAATGGATTACCGACAG
Restriction Sites Please inquire     
ACCN NM_001165979
ORF Size 5985 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Reference Data
RefSeq NM_001165979.1, NP_001159451.1
RefSeq Size 6456
RefSeq ORF 5985
Locus ID 51196
Protein Families Druggable Genome
Protein Pathways Calcium signaling pathway, Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system
Gene Summary This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
Transcript Variant: This variant (2) lacks two exons and has an additional novel exon at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a novel start codon, compared to variant 1. The encoded protein (isoform 2; also known as PLCepsilon1b) has a shorter and distinct N-terminus, compared to isoform 1.

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