KLHL2 (NM_001161522) Human Untagged Clone

CAT#: SC327569

KLHL2 (untagged)-Human kelch-like 2 Mayven (Drosophila) (KLHL2) transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KLHL2
• Synonyms: ABP-KELCH; MAV; MAYVEN
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001161522, the custom clone sequence may differ by one or more nucleotides
  ATGAGTGAGAGCCGAGCAAAGAGAGTTAGAATAAAAGAGGTAGATGGCTGGACCCTGAGG
  ATGCTAATTGATTATGTTTACACTGCAGAAATTCAGGTTACAGAAGAAAATGTACAGGTA
  CTTCTCCCAGCAGCTGGTCTCTTACAGTTACAGGATGTGAAGAAGACTTGTTGTGAATTT
  TTGGAATCCCAGCTTCACCCTGTCAACTGCTTAGGAATCCGGGCTTTTGCTGATATGCAT
  GCATGTACCGACCTTCTGAACAAGGCCAACACCTATGCAGAGCAACATTTTGCAGATGTT
  GTACTTAGTGAAGAATTTCTCAATCTTGGCATCGAACAAGTGTGCAGCTTAATCTCAAGT
  GACAAACTTACCATTTCTTCAGAAGAGAAGGTATTTGAAGCAGTAATAGCATGGGTGAAC
  CATGACAAGGATGTGAGGCAAGAGTTTATGGCCCGACTGATGGAACATGTACGGTTACCT
  TTGCTTCCTCGGGAATATTTAGTTCAGAGGGTTGAAGAGGAAGCATTGGTCAAGAATAGC
  AGTGCTTGCAAAGATTACCTCATTGAAGCAATGAAGTACCATTTGCTGCCAACAGAGCAG
  CGTATATTAATGAAGAGTGTCCGGACCCGGCTGAGGACACCCATGAACCTTCCCAAATTG
  ATGGTGGTGGTTGGGGGCCAAGCACCAAAGGCTATCCGGAGTGTGGAATGCTATGACTTT
  AAAGAAGAAAGGTGGCACCAAGTAGCAGAGTTGCCTTCCAGGAGGTGCAGGGCAGGCATG
  GTCTACATGGCTGGACTTGTTTTTGCTGTTGGTGGCTTTAATGGCTCATTAAGAGTTCGC
  ACTGTAGATTCCTACGACCCTGTGAAGGACCAGTGGACCAGCGTTGCTAACATGAGAGAC
  CGGAGAAGCACTTTGGGAGCTGCTGTGTTAAATGGATTATTATACGCTGTGGGAGGCTTT
  GATGGGAGTACAGGTTTGTCATCTGTGGAAGCATACAACATAAAGTCTAATGAGTGGTTT
  CATGTAGCTCCCATGAATACAAGGAGGAGCAGTGTTGGTGTGGGTGTTGTTGGAGGTTTG
  CTCTATGCTGTAGGAGGTTATGATGGAGCATCACGTCAGTGTCTTAGCACAGTAGAATGC
  TATAATGCTACAACAAATGAGTGGACCTATATAGCAGAAATGAGCACCAGGCGGAGTGGA
  GCAGGTGTTGGTGTGTTAAACAATTTATTGTATGCTGTAGGAGGTCATGATGGCCCTTTA
  GTACGAAAAAGTGTTGAAGTATATGATCCCACCACTAACGCATGGAGACAGGTTGCAGAT
  ATGAACATGTGCAGAAGAAATGCAGGAGTTTGTGCAGTTAATGGTCTGTTATATGTTGTT
  GGAGGGGATGATGGTTCCTGTAACTTGGCGTCAGTAGAATATTATAACCCAACAACCGAT
  AAATGGACAGTTGTGTCATCGTGTATGAGCACAGGGAGAAGTTATGCAGGGGTCACAGTT
  ATTGATAAACCATTA
  
• Restriction Sites: Please inquire
• ACCN: NM_001161522
• ORF Size: 1518 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001161522.1, NP_001154994.1
• RefSeq Size: 2907
• RefSeq ORF: 1518
• Locus ID: 11275
• Gene Summary: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.