TKTL1 (NM_001145934) Human Untagged Clone

CAT#: SC327584

TKTL1 (untagged)-Human transketolase-like 1 (TKTL1) transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TKTL1
• Synonyms: TKR; TKT2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001145934, the custom clone sequence may differ by one or more nucleotides
  ATGTCTGTGCTGTTCTTCTACATCATGAGGTACAAGCAGTCAGATCCAGAGAATCCGGAC
  AACGACCGATTTGTCCTCGCAAAGAGACTGTCGTTTGTGGATGTGGCAACAGGATGGCTC
  GGACAAGGACTGGGAGTTGCATGTGGAATGGCATATACTGGCAAGTACTTCGACAGGGCC
  AGCTACCGGGTGTTCTGCCTCATGAGTGATGGCGAGTCCTCAGAAGGCTCTGTCTGGGAG
  GCAATGGCCTTTGCTTCCTACTACAGTCTGGACAATCTTGTGGCAATCTTTGATGTGAAC
  CGCCTGGGACACAGTGGTGCATTGCCCGCCGAGCACTGCATAAACATCTATCAGAGGCGC
  TGCGAAGCCTTTGGGTGGAACACTTATGTGGTGGACGGCCGGGACGTGGAGGCACTGTGC
  CAGGTATTCTGGCAGGCTTCTCAGGTGAAGCACAAGCCCACTGCTGTGGTGGCCAAGACC
  TTCAAGGGCCGGGGCACCCCAAGTATTGAGGATGCAGAAAGTTGGCATGCAAAGCCAATG
  CCGAGAGAAAGAGCAGATGCCATTATCAAATTAATTGAGAGCCAGATACAGACCAGCAGG
  AATCTTGACCCACAGCCCCCCATTGAGGACTCACCTGAAGTCAACATCACAGATGTAAGG
  ATGACCTCTCCACCTGATTACAGAGTTGGTGACAAGATAGCTACTCGGAAAGCATGCGGT
  CTGGCTCTGGCTAAGCTGGGCTACGCGAACAACAGAGTCGTTGTGCTGGATGGTGACACC
  AGGTACTCTACTTTCTCTGAGATATTCAACAAGGAGTACCCTGAGCGCTTCATCGAGTGC
  TTTATGGCTGAACAAAACATGGTGAGCGTGGCTCTGGGCTGTGCCTCCCGTGGACGGACC
  ATTGCTTTTGCTAGCACCTTTGCTGCCTTTCTGACTCGAGCATTTGATCACATCCGGATA
  GGAGGCCTCGCTGAGAGCAACATCAACATTATTGGTTCCCACTGTGGGGTATCTGTTGGT
  GACGATGGTGCTTCCCAGATGGCCCTGGAGGATATAGCCATGTTCCGAACCATTCCCAAG
  TGCACGATCTTCTACCCAACTGATGCCGTCTCCACGGAGCATGCTGTTGCTCTGGCAGCC
  AATGCCAAGGGGATGTGCTTCATTCGGACCACCCGACCAGAAACTATGGTTATTTACACC
  CCACAAGAACGCTTTGAGATCGGACAGGCCAAGGTCCTCCGCCACTGTGTCAGTGACAAG
  GTCACAGTTATTGGAGCTGGAATTACTGTGTATGAAGCCTTAGCAGCTGCTGATGAGCTT
  TCGAAACAAGATATTTTTATCCGTGTCATCGACCTGTTTACCATTAAACCTCTGGATGTC
  GCCACCATCGTCTCCAGTGCAAAAGCCACAGAGGGCCGGATCATTACAGTGGAGGATCAC
  TACCCGCAAGGTGGCATCGGGGAAGCTGTCTGCGCAGCCGTCTCCATGGATCCTGACATT
  CAGGTTCATTCGCTGGCAGTGTCGGGAGTGCCCCAGAGTGGGAAGTCCGAGGAATTGCTG
  GATATGTATGGAATTAGTGCCAGACATATCATAGTGGCCGTGAAATGCATGTTGCTGAAC
  
• Restriction Sites: Please inquire
• ACCN: NM_001145934
• ORF Size: 1623 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001145934.1, NP_001139406.1
• RefSeq Size: 2579
• RefSeq ORF: 1623
• Locus ID: 8277
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Pentose phosphate pathway
• Gene Summary: The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
  Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.