Frizzled 6 (FZD6) (NM_001164616) Human Untagged Clone

CAT#: SC327629

FZD6 (untagged)-Human frizzled homolog 6 (Drosophila) (FZD6) transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FZD6
• Synonyms: FZ-6; FZ6; HFZ6; NDNC10
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001164616, the custom clone sequence may differ by one or more nucleotides
  ATGAAAATGGCCTACAACATGACGTTTTTCCCTAATCTGATGGGTCATTATGACCAGAGT
  ATTGCCGCGGTGGAAATGGAGCATTTTCTTCCTCTCGCAAATCTGGAATGTTCACCAAAC
  ATTGAAACTTTCCTCTGCAAAGCATTTGTACCAACCTGCATAGAACAAATTCATGTGGTT
  CCACCTTGTCGTAAACTTTGTGAGAAAGTATATTCTGATTGCAAAAAATTAATTGACACT
  TTTGGGATCCGATGGCCTGAGGAGCTTGAATGTGACAGATTACAATACTGTGATGAGACT
  GTTCCTGTAACTTTTGATCCACACACAGAATTTCTTGGTCCTCAGAAGAAAACAGAACAA
  GTCCAAAGAGACATTGGATTTTGGTGTCCAAGGCATCTTAAGACTTCTGGGGGACAAGGA
  TATAAGTTTCTGGGAATTGACCAGTGTGCGCCTCCATGCCCCAACATGTATTTTAAAAGT
  GATGAGCTAGAGTTTGCAAAAAGTTTTATTGGAACAGTTTCAATATTTTGTCTTTGTGCA
  ACTCTGTTCACATTCCTTACTTTTTTAATTGATGTTAGAAGATTCAGATACCCAGAGAGA
  CCAATTATATATTACTCTGTCTGTTACAGCATTGTATCTCTTATGTACTTCATTGGATTT
  TTGCTAGGCGATAGCACAGCCTGCAATAAGGCAGATGAGAAGCTAGAACTTGGTGACACT
  GTTGTCCTAGGCTCTCAAAATAAGGCTTGCACCGTTTTGTTCATGCTTTTGTATTTTTTC
  ACAATGGCTGGCACTGTGTGGTGGGTGATTCTTACCATTACTTGGTTCTTAGCTGCAGGA
  AGAAAATGGAGTTGTGAAGCCATCGAGCAAAAAGCAGTGTGGTTTCATGCTGTTGCATGG
  GGAACACCAGGTTTCCTGACTGTTATGCTTCTTGCTATGAACAAAGTTGAAGGAGACAAC
  ATTAGTGGAGTTTGCTTTGTTGGCCTTTATGACCTGGATGCTTCTCGCTACTTTGTACTC
  TTGCCACTGTGCCTTTGTGTGTTTGTTGGGCTCTCTCTTCTTTTAGCTGGCATTATTTCC
  TTAAATCATGTTCGACAAGTCATACAACATGATGGCCGGAACCAAGAAAAACTAAAGAAA
  TTTATGATTCGAATTGGAGTCTTCAGCGGCTTGTATCTTGTGCCATTAGTGACACTTCTC
  GGATGTTACGTCTATGAGCAAGTGAACAGGATTACCTGGGAGATAACTTGGGTCTCTGAT
  CATTGTCGTCAGTACCATATCCCATGTCCTTATCAGGCAAAAGCAAAAGCTCGACCAGAA
  TTGGCTTTATTTATGATAAAATACCTGATGACATTAATTGTTGGCATCTCTGCTGTCTTC
  TGGGTTGGAAGCAAAAAGACATGCACAGAATGGGCTGGGTTTTTTAAACGAAATCGCAAG
  AGAGATCCAATCAGTGAAAGTCGAAGAGTACTACAGGAATCATGTGAGTTTTTCTTAAAG
  CACAATTCTAAAGTTAAACACAAAAAGAAGCACTATAAACCAAGTTCACACAAGCTGAAG
  GTCATTTCCAAATCCATGGGAACCAGCACAGGAGCTACAGCAAATCATGGCACTTCTGCA
  GTAGCAATTACTAGCCATGATTACCTAGGACAAGAAACTTTGACAGAAATCCAAACCTCA
  CCAGAAACATCAATGAGAGAGGTGAAAGCGGACGGAGCTAGCACCCCCAGGTTAAGAGAA
  CAGGACTGTGGTGAACCTGCCTCGCCAGCAGCATCCATCTCCAGACTCTCTGGGGAACAG
  GTCGACGGGAAGGGCCAGGCAGGCAGTGTATCTGAAAGTGCGCGGAGTGAAGGAAGGATT
  AGTCCAAAGAGTGATATTACTGACACTGGCCTGGCACAGAGCAACAATTTGCAGGTCCCC
  AGTTCTTCAGAACCAAGCAGCCTCAAAGGTTCCACATCTCTGCTTGTTCACCCGGTTTCA
  GGAGTGAGAAAAGAGCAGGGAGGTGGTTGTCATTCAGATACT
  
• Restriction Sites: Please inquire
• ACCN: NM_001164616
• ORF Size: 2025 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001164616.1, NP_001158088.1
• RefSeq Size: 3691
• RefSeq ORF: 2025
• Locus ID: 8323
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway
• Gene Summary: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide. [provided by RefSeq, Aug 2011]
  Transcript Variant: This variant (3) lacks a segment of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.