Frizzled 6 (FZD6) (NM_001164615) Human Untagged Clone

CAT#: SC327636

FZD6 (untagged)-Human frizzled homolog 6 (Drosophila) (FZD6) transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FZD6
• Synonyms: FZ-6; FZ6; HFZ6; NDNC10
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001164615, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAAATGTTTACATTTTTGTTGACGTGTATTTTTCTACCCCTCCTAAGAGGGCACAGTCTCTTCACCT
  GTGAACCAATTACTGTTCCCAGATGTATGAAAATGGCCTACAACATGACGTTTTTCCCTAATCTGATGGG
  TCATTATGACCAGAGTATTGCCGCGGTGGAAATGGAGCATTTTCTTCCTCTCGCAAATCTGGAATGTTCA
  CCAAACATTGAAACTTTCCTCTGCAAAGCATTTGTACCAACCTGCATAGAACAAATTCATGTGGTTCCAC
  CTTGTCGTAAACTTTGTGAGAAAGTATATTCTGATTGCAAAAAATTAATTGACACTTTTGGGATCCGATG
  GCCTGAGGAGCTTGAATGTGACAGATTACAATACTGTGATGAGACTGTTCCTGTAACTTTTGATCCACAC
  ACAGAATTTCTTGGTCCTCAGAAGAAAACAGAACAAGTCCAAAGAGACATTGGATTTTGGTGTCCAAGGC
  ATCTTAAGACTTCTGGGGGACAAGGATATAAGTTTCTGGGAATTGACCAGTGTGCGCCTCCATGCCCCAA
  CATGTATTTTAAAAGTGATGAGCTAGAGTTTGCAAAAAGTTTTATTGGAACAGTTTCAATATTTTGTCTT
  TGTGCAACTCTGTTCACATTCCTTACTTTTTTAATTGATGTTAGAAGATTCAGATACCCAGAGAGACCAA
  TTATATATTACTCTGTCTGTTACAGCATTGTATCTCTTATGTACTTCATTGGATTTTTGCTAGGCGATAG
  CACAGCCTGCAATAAGGCAGATGAGAAGCTAGAACTTGGTGACACTGTTGTCCTAGGCTCTCAAAATAAG
  GCTTGCACCGTTTTGTTCATGCTTTTGTATTTTTTCACAATGGCTGGCACTGTGTGGTGGGTGATTCTTA
  CCATTACTTGGTTCTTAGCTGCAGGAAGAAAATGGAGTTGTGAAGCCATCGAGCAAAAAGCAGTGTGGTT
  TCATGCTGTTGCATGGGGAACACCAGGTTTCCTGACTGTTATGCTTCTTGCTATGAACAAAGTTGAAGGA
  GACAACATTAGTGGAGTTTGCTTTGTTGGCCTTTATGACCTGGATGCTTCTCGCTACTTTGTACTCTTGC
  CACTGTGCCTTTGTGTGTTTGTTGGGCTCTCTCTTCTTTTAGCTGGCATTATTTCCTTAAATCATGTTCG
  ACAAGTCATACAACATGATGGCCGGAACCAAGAAAAACTAAAGAAATTTATGATTCGAATTGGAGTCTTC
  AGCGGCTTGTATCTTGTGCCATTAGTGACACTTCTCGGATGTTACGTCTATGAGCAAGTGAACAGGATTA
  CCTGGGAGATAACTTGGGTCTCTGATCATTGTCGTCAGTACCATATCCCATGTCCTTATCAGGCAAAAGC
  AAAAGCTCGACCAGAATTGGCTTTATTTATGATAAAATACCTGATGACATTAATTGTTGGCATCTCTGCT
  GTCTTCTGGGTTGGAAGCAAAAAGACATGCACAGAATGGGCTGGGTTTTTTAAACGAAATCGCAAGAGAG
  ATCCAATCAGTGAAAGTCGAAGAGTACTACAGGAATCATGTGAGTTTTTCTTAAAGCACAATTCTAAAGT
  TAAACACAAAAAGAAGCACTATAAACCAAGTTCACACAAGCTGAAGGTCATTTCCAAATCCATGGGAACC
  AGCACAGGAGCTACAGCAAATCATGGCACTTCTGCAGTAGCAATTACTAGCCATGATTACCTAGGACAAG
  AAACTTTGACAGAAATCCAAACCTCACCAGAAACATCAATGAGAGAGGTGAAAGCGGACGGAGCTAGCAC
  CCCCAGGTTAAGAGAACAGGACTGTGGTGAACCTGCCTCGCCAGCAGCATCCATCTCCAGACTCTCTGGG
  GAACAGGTCGACGGGAAGGGCCAGGCAGGCAGTGTATCTGAAAGTGCGCGGAGTGAAGGAAGGATTAGTC
  CAAAGAGTGATATTACTGACACTGGCCTGGCACAGAGCAACAATTTGCAGGTCCCCAGTTCTTCAGAACC
  AAGCAGCCTCAAAGGTTCCACATCTCTGCTTGTTCACCCGGTTTCAGGAGTGAGAAAAGAGCAGGGAGGT
  GGTTGTCATTCAGATACTTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001164615
• ORF Size: 2121 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001164615.1, NP_001158087.1
• RefSeq Size: 3779
• RefSeq ORF: 2121
• Locus ID: 8323
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway
• Gene Summary: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide. [provided by RefSeq, Aug 2011]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.