Acinus (ACIN1) (NM_001164814) Human Untagged Clone

CAT#: SC327709

ACIN1 (untagged)-Human apoptotic chromatin condensation inducer 1 (ACIN1) transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ACIN1
• Synonyms: ACINUS; ACN; fSAP152
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001164814, the custom clone sequence may differ by one or more nucleotides
  ATGTGGAGACGGAAACATCCGAGGACATCCGGAGGAACCCGGGGAGTTCTGAGTGGTAAT
  CGAGGGGTAGAGTATGGCAGTGGGCGGGGTCATCTCGGTACGTTCGAAGGGCGTTGGCGG
  AAATTACCGAAGATGCCCGAAGCCGTCGGGACGGACCCGAGTACCTCACGCAAGATGGCG
  GAGCTGGAGGAGGTGACTCTGGACGGGAAGCCTCTTCAGGCGCTGCGGGTGACCGACCTG
  AAGGCCGCACTGGAGCAGCGAGGCCTAGCCAAGAGCGGGCAGAAGAGTGCCCTGGTCAAG
  CGGCTCAAAGGGGCTCTAATGCTAGAAAATTTACAGAAACACTCAACACCCCATGCTGCA
  TTCCAGCCAAATTCCCAGATTGGTGAGGAAATGAGCCAGAACAGTTTCATAAAACAGTAT
  CTGGAAAAGCAGCAGGAGCTACTTAGGCAGCGTCTGGAACGTGAAGCTCGAGAAGCTGCA
  GAACTTGAAGAAGCTTCAGCTGAGTCGGAGGACGAGATGATCCATCCTGAGGGAGTGGCT
  TCCCTGCTGCCTCCTGACTTTCAGAGCAGCCTGGAGAGACCAGAGCTGGAGCTCAGCAGA
  CATTCGCCCAGAAAAAGCTCCTCAATTTCTGAAGAGAAAGGTGACTCTGATGATGAGAAA
  CCAAGGAAAGGAGAAAGACGATCATCTAGGGTCAGACAGGCAAGAGCAGCTAAACTGTCT
  GAGGGCAGCCAACCTGCTGAGGAGGAAGAGGATCAAGAAACACCTTCCAGAAACCTAAGG
  GTCAGAGCAGATCGAAATTTGAAAACAGAGGAGGAAGAAGAGGAGGAGGAGGAGGAGGAA
  GAAGATGATGAAGAAGAGGAAGGTGATGATGAGGGACAAAAATCTAGGGAGGCACCAATC
  CTGAAAGAGTTTAAGGAAGAAGGGGAAGAGATACCTAGAGTAAAACCAGAGGAGATGATG
  GATGAGAGACCCAAAACAAGATCCCAGGAACAGGAGGTGTTAGAGAGAGGAGGGAGATTT
  ACAAGATCCCAGGAAGAGGCTAGAAAAAGTCATCTGGCCAGACAGCAGCAGGAGAAGGAA
  ATGAAAACAACATCTCCCCTTGAGGAGGAAGAAAGAGAAATAAAATCTTCACAAGGCTTA
  AAGGAAAAATCGAAGTCTCCTTCCCCTCCTCGACTGACTGAAGATCGAAAGAAGGCCTCA
  CTTGTAGCGCTGCCAGAGCAAACTGCCAGCGAGGAGGAGACTCCTCCACCTTTACTAACA
  AAGGAAGCATCTTCTCCACCACCTCATCCACAGCTCCATAGCGAAGAAGAAATAGAGCCC
  ATGGAAGGCCCAGCCCCCCCTGTCCTCATTCAGTTATCTCCTCCTAATACAGATGCTGAC
  ACCAGGGAGCTATTAGTATCTCAGCATACTGTCCAGTTGGTAGGAGGCCTGTCTCCTTTG
  TCAAGTCCTTCAGACACCAAAGCAGAATCTCCAGCAGAGAAAGTGCCAGAGGAGAGTGTC
  CTGCCTCTGGTTCAGAAAAGCACACTGGCTGACTACTCAGCCCAGAAGGATCTTGAACCT
  GAGTCAGACAGATCTGCTCAGCCCCTCCCTCTAAAAATTGAGGAATTAGCACTGGCCAAA
  GGAATCACTGAAGAATGTCTGAAACAGCCATCTTTGGAACAGAAGGAAGGCAGAAGAGCT
  TCTCATACCCTTCTCCCAAGCCACAGATTGAAACAGTCAGCTGATTCATCCTCTAGCCGG
  TCCTCCTCATCTTCCTCCTCCAGTTCTAGATCAAGATCTCGCTCTCCTGACAGTTCAGGT
  TCTCGGTCTCATTCACCGCTCAGATCCAAGCAGAGAGATGTAGCCCAGGCACGTACTCAT
  GCCAACCCTCGTGGTAGACCCAAGATGGGCTCCAGATCAACATCAGAGTCCAGATCAAGG
  TCACGTTCACGTTCTCGTTCAGCATCAAGCAACAGCAGAAAATCTCTGAGCCCTGGAGTC
  TCCAGGGACAGCAGCACCAGCTATACTGAAACCAAAGATCCCTCTTCTGGTCAGGAGGTT
  GCAACTCCACCAGTGCCACAACTGCAGGTCTGTGAGCCAAAGGAGAGGACTTCCACCTCC
  TCATCCTCTGTCCAAGCAAGGCGTCTGAGTCAGCCTGAATCAGCTGAAAAGCATGTGACC
  CAGAGGTTACAGCCTGAGCGGGGGAGCCCAAAGAAGTGTGAAGCTGAAGAGGCAGAGCCA
  CCAGCTGCCACACAGCCCCAAACCTCAGAGACTCAGACCTCTCATCTGCCAGAATCAGAA
  AGAATTCATCACACTGTTGAGGAGAAGGAGGAAGTGACCATGGACACAAGTGAAAACAGA
  CCTGAAAATGATGTTCCAGAACCTCCCATGCCTATTGCAGACCAAGTCAGCAATGATGAC
  CGCCCGGAGGGCAGTGTTGAAGATGAGGAGAAGAAAGAGAGCTCGCTGCCCAAATCATTC
  AAGAGGAAGATCTCCGTTGTCTCTACCAAGGGGGTGCCAGCTGGAAACAGTGACACAGAG
  GGGGGCCAGCCTGGTCGGAAACGACGCTGGGGAGCCAGCACAGCCACCACACAGAAGAAA
  CCTTCCATCAGTATCACCACTGAATCACTAAAGGAGGCTGTTGTGGATCTTCATGCTGAT
  GACTCTCGCATCTCTGAGGATGAGACAGAGCGTAATGGCGATGATGGGACCCATGACAAG
  GGGCTGAAAATATGCCGGACAGTCACTCAGGTAGTACCTGCAGAGGGCCAGGAGAATGGG
  CAGAGGGAAGAAGAGGAAGAAGAGAAGGAACCTGAAGCAGAACCTCCTGTACCTCCCCAG
  GTGTCAGTAGAGGTGGCCTTGCCCCCACCTGCAGAGCATGAAGTAAAGAAAGTGACTTTA
  GGAGATACCTTAACTCGACGTTCCATTAGCCAGCAGAAGTCCGGAGTTTCCATTACCATT
  GATGACCCAGTCCGAACTGCCCAGGTGCCCTCCCCACCCCGGGGCAAGATTAGCAACATT
  GTCCATATCTCCAATTTGGTCCGTCCTTTCACTTTAGGCCAGCTAAAGGAGTTGTTGGGG
  CGCACAGGAACCTTGGTGGAAGAGGCCTTCTGGATTGACAAGATCAAATCTCATTGCTTT
  GTAACGTACTCAACAGTAGAGGAAGCTGTTGCCACCCGCACAGCTCTGCACGGGGTCAAA
  TGGCCCCAGTCCAATCCCAAATTCCTTTGTGCTGACTATGCCGAGCAAGATGAGCTGGAT
  TATCACCGAGGCCTCTTGGTGGACCGTCCCTCTGAAACTAAGACAGAGGAGCAGGGAATA
  CCACGGCCCCTGCACCCCCCACCCCCACCCCCGGTCCAGCCACCACAGCACCCCCGGGCA
  GAGCAGCGGGAGCAGGAACGGGCAGTGCGGGAACAGTGGGCAGAACGGGAACGGGAAATG
  GAGCGGCGGGAGCGGACTCGATCAGAGCGTGAATGGGATCGGGACAAAGTTCGAGAAGGG
  CCCCGTTCCCGATCAAGGTCCCGTGACCGCCGCCGCAAGGAACGTGCGAAGTCTAAAGAA
  AAGAAGAGTGAGAAGAAAGAGAAAGCCCAGGAGGAACCACCTGCCAAGCTGCTGGATGAC
  CTTTTCCGAAAGACCAAGGCAGCTCCCTGCATCTATTGGCTCCCACTGACTGACAGCCAG
  ATCGTTCAGAAAGAGGCAGAGCGGGCCGAACGGGCCAAGGAGCGGGAGAAGCGGCGAAAG
  GAGCAAGAAGAAGAAGAGCAAAAGGAGCGGGAGAAGGAAGCCGAGCGGGAACGGAACCGA
  CAGCTGGAGCGAGAGAAACGTCGGGAGCACAGTCGGGAGAGGGACAGGGAGAGAGAGAGA
  GAAAGGGAGCGGGACAGGGGGGACCGAGATCGGGATAGGGAAAGGGACCGAGAACGAGGC
  AGGGAAAGGGATCGCAGGGACACCAAGCGCCACAGCAGAAGCCGGAGTCGGAGCACACCT
  GTGCGGGACCGGGGTGGGCGCCGC
  
• Restriction Sites: Please inquire
• ACCN: NM_001164814
• ORF Size: 3987 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001164814.1, NP_001158286.1
• RefSeq Size: 4909
• RefSeq ORF: 3987
• Locus ID: 22985
• Protein Pathways: Spliceosome
• Gene Summary: Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
  Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.