BCAR1 (NM_001170721) Human Untagged Clone

CAT#: SC329042

BCAR1 (untagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1) transcript variant 9

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BCAR1
• Synonyms: CAS; CAS1; CASS1; CRKAS; P130Cas
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001170721, the custom clone sequence may differ by one or more nucleotides
  ATGGTGGTGGTGCCCACCCGCGTGGGGCAGGGCTATGTATACGAGGCCGCCCAGCCGGAG
  CAGGACGAGTACGACATCCCGCGACACCTGCTGGCCCCGGGGCCACAGGACATCTATGAT
  GTGCCCCCGGTTCGGGGGCTGCTTCCCAGCCAGTATGGCCAGGAGGTGTATGACACACCC
  CCCATGGCTGTCAAGGGTCCCAATGGCCGAGACCCGTTGCTGGAGGTGTATGACGTGCCC
  CCCAGTGTGGAGAAGGGCCTGCCACCGTCCAACCACCACGCAGTCTACGACGTTCCTCCA
  TCGGTGAGCAAGGATGTGCCCGATGGCCCACTGCTGCGTGAGGAGACCTACGATGTGCCC
  CCCGCCTTCGCCAAGGCCAAGCCCTTTGACCCGGCCCGCACCCCACTGGTACTGGCTGCG
  CCCCCTCCAGACTCCCCGCCGGCCGAGGACGTGTATGACGTGCCGCCCCCGGCTCCTGAC
  CTCTACGACGTGCCCCCTGGCTTGCGGCGGCCTGGCCCGGGCACCCTGTACGATGTGCCC
  CGTGAACGGGTGCTTCCTCCTGAGGTGGCTGATGGTGGCGTGGTCGACAGTGGTGTGTAT
  GCGGTGCCTCCCCCAGCTGAACGTGAAGCCCCGGCAGAGGGCAAGCGCCTGTCGGCCTCC
  AGCACCGGCAGCACACGCAGCAGCCAGTCTGCGTCCTCCTTGGAGGTGGCAGGGCCGGGC
  CGGGAACCCCTGGAGCTGGAAGTTGCTGTGGAGGCCCTGGCACGGCTGCAGCAGGGTGTG
  AGCGCCACCGTTGCCCACCTTCTGGACCTGGCAGGCAGCGCCGGTGCGACTGGGAGCTGG
  CGTAGCCCCTCTGAGCCACAGGAGCCGCTGGTGCAGGACCTGCAGGCTGCTGTGGCCGCT
  GTCCAGAGTGCCGTCCACGAGCTGTTGGAGTTTGCCCGCAGCGCGGTGGGCAATGCTGCC
  CACACATCTGACCGTGCCCTGCATGCCAAGCTTAGCCGGCAGCTGCAGAAGATGGAGGAC
  GTGCACCAGACGCTGGTGGCACATGGTCAGGCCCTCGACGCTGGCCGGGGAGGCTCTGGA
  GCCACCCTTGAGGACCTGGACCGGCTGGTGGCCTGCTCGCGGGCTGTGCCCGAGGACGCC
  AAGCAGCTGGCCTCCTTCCTGCACGGCAATGCCTCACTGCTCTTCAGACGGACCAAGGCC
  ACTGCCCCGGGGCCTGAGGGGGGTGGCACCCTGCACCCCAACCCCACTGACAAGACCAGC
  AGCATCCAGTCACGACCCCTGCCCTCACCCCCTAAGTTCACCTCCCAGGACTCGCCAGAT
  GGGCAGTACGAGAACAGCGAGGGGGGCTGGATGGAGGACTATGACTACGTCCACCTACAG
  GGGAAGGAGGAGTTTGAGAAGACCCAGAAGGAGCTGCTGGAAAAGGGCAGCATCACGCGG
  CAGGGCAAGAGCCAGCTGGAGTTGCAGCAGCTGAAGCAGTTTGAACGACTGGAACAGGAG
  GTGTCACGGCCCATAGACCACGACCTGGCCAACTGGACGCCAGCCCAACCCCTGGCCCCG
  GGGCGAACAGGCGGCCTGGGGCCCTCGGACCGGCAGCTGCTGCTCTTCTACCTGGAGCAG
  TGTGAGGCCAACCTGACCACACTGACCAACGCCGTGGACGCCTTCTTTACCGCCGTGGCC
  ACCAACCAGCCGCCCAAGATCTTTGTGGCGCACAGCAAGTTCGTCATCCTCAGCGCCCAC
  AAGCTGGTGTTCATCGGGGACACACTGTCACGGCAGGCCAAGGCTGCTGACGTGCGCAGC
  CAGGTGACCCACTACAGCAACCTGCTGTGCGACCTCCTGCGCGGCATCGTGGCCACCACC
  AAGGCCGCTGCCTTGCAGTACCCATCGCCTTCCGCGGCCCAGGACATGGTGGAGAGGGTC
  AAGGAGCTGGGCCACAGCACCCAGCAGTTCCGCCGCGTCCTAGGCCAGCTGGCAGCCGCC
  TGA
  
• Restriction Sites: Please inquire
• ACCN: NM_001170721
• ORF Size: 1983 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001170721.1, NP_001164192.1
• RefSeq Size: 3470
• RefSeq ORF: 1983
• Locus ID: 9564
• Protein Families: Druggable Genome
• Protein Pathways: Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton
• Gene Summary: The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017]
  Transcript Variant: This variant (9) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (9) is much shorter at the N-terminus, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.