STAT2 (NM_198332) Human Untagged Clone

CAT#: SC329176

STAT2 (untagged)-Human signal transducer and activator of transcription 2 113kDa (STAT2) transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: STAT2
• Synonyms: IMD44; ISGF-3; P113; STAT113
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_198332, the custom clone sequence may differ by one or more nucleotides
  ATGGCGCAGTGGGAAATGCTGCAGAATCTTGACAGCCCCTTTCAGGATCAGCTGCACCAG
  CTTTACTCGCACAGCCTCCTGCCTGTGGACATTCGACAGTACTTGGCTGTCTGGATTGAA
  GACCAGAACTGGCAGGAAGCTGCACTTGGGAGTGATGATTCCAAGGCTACCATGCTATTC
  TTCCACTTCTTGGATCAGCTGAACTATGAGTGTGGCCGTTGCAGCCAGGACCCAGAGTCC
  TTGTTGCTGCAGCACAATTTGCGGAAATTCTGCCGGGACATTCAGGATCCTACCCAGTTG
  GCTGAGATGATCTTTAACCTCCTTCTGGAAGAAAAAAGAATTTTGATCCAGGCTCAGAGG
  GCCCAATTGGAACAAGGAGAGCCAGTTCTCGAAACACCTGTGGAGAGCCAGCAACATGAG
  ATTGAATCCCGGATCCTGGATTTAAGGGCTATGATGGAGAAGCTGGTAAAATCCATCAGC
  CAACTGAAAGACCAGCAGGATGTCTTCTGCTTCCGATATAAGATCCAGGCCAAAGGGAAG
  ACACCCTCTCTGGACCCCCATCAGACCAAAGAGCAGAAGATTCTGCAGGAAACTCTCAAT
  GAACTGGACAAAAGGAGAAAGGAGGTGCTGGATGCCTCCAAAGCACTGCTAGGCCGATTA
  ACTACCCTAATCGAGCTACTGCTGCCAAAGTTGGAGGAGTGGAAGGCCCAGCAGCAAAAA
  GCCTGCATCAGAGCTCCCATTGACCACGGGTTGGAACAGCTGGAGACATGGTTCACAGCT
  GGAGCAAAGCTGTTGTTTCACCTGAGGCAGCTGCTGAAGGAGCTGAAGGGACTGAGTTGC
  CTGGTTAGCTATCAGGATGACCCTCTGACCAAAGGGGTGGACCTACGCAACGCCCAGGTC
  ACAGAGTTGCTACAGCGTCTGCTCCACAGAGCCTTTGTGGTAGAAACCCAGCCCTGCATG
  CCCCAAACTCCCCATCGACCCCTCATCCTCAAGACTGGCAGCAAGTTCACCGTCCGAACA
  AGGCTGCTGGTGAGACTCCAGGAAGGCAATGAGTCACTGACTGTGGAAGTCTCCATTGAC
  AGGAATCCTCCTCAATTACAAGGCTTCCGGAAGTTCAACATTCTGACTTCAAACCAGAAA
  ACTTTGACCCCCGAGAAGGGGCAGAGTCAGGGTTTGATTTGGGACTTTGGTTACCTGACT
  CTGGTGGAGCAACGTTCAGGTGGTTCAGGAAAGGGCAGCAATAAGGGGCCACTAGGTGTG
  ACAGAGGAACTGCACATCATCAGCTTCACGGTCAAATATACCTACCAGGGTCTGAAGCAG
  GAGCTGAAAACGGACACCCTCCCTGTGGTGATTATTTCCAACATGAACCAGCTCTCAATT
  GCCTGGGCTTCAGTTCTCTGGTTCAATTTGCTCAGCCCAAACCTTCAGAACCAGCAGTTC
  TTCTCCAACCCCCCCAAGGCCCCCTGGAGCTTGCTGGGCCCTGCTCTCAGTTGGCAGTTC
  TCCTCCTATGTTGGCCGAGGCCTCAACTCAGACCAGCTGAGCATGCTGAGAAACAAGCTG
  TTCGGGCAGAACTGTAGGACTGAGGATCCATTATTGTCCTGGGCTGACTTCACTAAGCGA
  GAGAGCCCTCCTGGCAAGTTACCATTCTGGACATGGCTGGACAAAATTCTGGAGTTGGTA
  CATGACCACCTGAAGGATCTCTGGAATGATGGACGCATCATGGGCTTTGTGAGTCGGAGC
  CAGGAGCGCCGGCTGCTGAAGAAGACCATGTCTGGCACCTTTCTACTGCGCTTCAGTGAA
  TCGTCAGAAGGGGGCATTACCTGCTCCTGGGTGGAGCACCAGGATGATGACAAGGTGCTC
  ATCTACTCTGTGCAACCGTACACGAAGGAGGTGCTGCAGTCACTCCCGCTGACTGAAATC
  ATCCGCCATTACCAGTTGCTCACTGAGGAGAATATACCTGAAAACCCACTGCGCTTCCTC
  TATCCCCGAATCCCCCGGGATGAAGCTTTTGGGTGCTACTACCAGGAGAAAGTTAATCTC
  CAGGAACGGAGGAAATACCTGAAACACAGGCTCATTGTGGTCTCTAATAGACAGGTGGAT
  GAACTGCAACAACCGCTGGAGCTTAAGCCAGAGCCAGAGCTGGAGTCATTAGAGCTGGAA
  CTAGGGCTGGTGCCAGAGCCAGAGCTCAGCCTGGACTTAGAGCCACTGCTGAAGGCAGGG
  CTGGATCTGGGGCCAGAGCTAGAGTCTGTGCTGGAGTCCACTCTGGAGCCTGTGATAGAG
  CCCACACTATGCATGGTATCACAAACAGTGCCAGAGCCAGACCAAGGACCTGTATCACAG
  CCAGTGCCAGAGCCAGATTTGCCCTGTGATCTGAGACATTTGAACACTGAGCCAATGGAA
  ATCTTCAGAAACTGTGTAAAGATTGAAGAAATCATGCCGAATGGTGACCCACTGTTGGCT
  GGCCAGAACACCGTGGATGAGGTTTACGTCTCCCGCCCCAGCCACTTCTACACTGATGGA
  CCCTTGATGCCTTCTGACTTCTAG
  
• Restriction Sites: Please inquire
• ACCN: NM_198332
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_198332.1, NP_938146.1
• RefSeq Size: 4564 bp
• RefSeq ORF: 2544 bp
• Locus ID: 6773
• Cytogenetics: 12q13.3
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Chemokine signaling pathway, Jak-STAT signaling pathway
• Gene Summary: 'The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020]'
  Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (2) lacks an internal 4-aa segment, compared to isoform 1.