PHF8 (NM_001184898) Human Untagged Clone

CAT#: SC329194

PHF8 (untagged)-Human PHD finger protein 8 (PHF8) transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PHF8
• Synonyms: JHDM1F; KDM7B; MRXSSD; ZNF422
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001184898, the custom clone sequence may differ by one or more nucleotides
  ATGGCCTCGGTGCCGGTGTATTGCCTCTGCCGGCTGCCTTACGATGTGACCCGCTTCATG
  ATCGAGTGTGACATGTGCCAGGACTGGTTTCATGGCAGTTGTGTTGGTGTTGAAGAGGAG
  AAGGCTGCTGACATTGACCTCTACCACTGCCCCAACTGTGAAGTCTTGCATGGGCCCTCC
  ATTATGAAAAAACGCCGTGGATCTTCAAAGGGGCATGATACACACAAGGGGAAACCAGTG
  AAGACCGGGAGCCCTACGTTCGTCAGAGAGCTCCGGAGTAGGACTTTTGACAGCTCAGAT
  GAAGTGATTCTGAAGCCCACTGGAAATCAACTGACCGTGGAATTCCTGGAAGAAAATAGC
  TTCAGTGTGCCCATCCTGGTCCTGAAGAAGGATGGGTTGGGCATGACGCTGCCCTCGCCA
  TCATTCACTGTGAGGGATGTTGAACACTATGTTGGTTCTGACAAAGAGATTGATGTGATT
  GATGTGACCCGCCAGGCTGACTGCAAGATGAAGCTTGGTGATTTTGTGAAATACTATTAC
  AGCGGGAAGAGGGAGAAAGTCCTCAATGTCATTAGTTTGGAATTCTCTGATACCAGACTT
  TCTAACCTTGTGGAGACACCGAAGATTGTTCGAAAGCTGTCATGGGTCGAAAACTTGTGG
  CCAGAGGAATGTGTCTTTGAGAGACCCAATGTACAGAAGTACTGCCTCATGAGTGTGCGA
  GATAGCTATACAGACTTTCACATTGACTTTGGTGGCACCTCTGTCTGGTACCATGTACTC
  AAGGGTGAAAAGATCTTCTACCTGATCCGCCCAACAAATGCCAATCTGACTCTCTTTGAG
  TGCTGGAGCAGTTCCTCTAATCAGAATGAGATGTTCTTTGGGGACCAGGTGGACAAGTGC
  TACAAGTGTTCCGTGAAGCAAGGACAGACACTTTTCATTCCCACAGGGTGGATCCATGCT
  GTGCTGACGCCTGTGGACTGCCTTGCCTTTGGAGGGAACTTCTTACACAGCCTTAACATC
  GAGATGCAGCTCAAAGCCTATGAGATTGAGAAGCGGCTGAGCACAGCAGACCTCTTCAGA
  TTCCCCAACTTTGAGACCATCTGTTGGTATGTGGGAAAGCACATCCTGGACATCTTTCGC
  GGTTTGCGAGAGAACAGGAGACACCCTGCCTCCTACCTGGTCCATGGTGGCAAAGCCTTG
  AACTTGGCCTTTAGAGCCTGGACAAGGAAAGAAGCTCTGCCAGACCATGAGGATGAGATC
  CCGGAGACAGTGCGAACCGTACAGCTCATTAAAGATCTGGCCAGGGAGATCCGCCTGGTG
  GAAGACATCTTCCAACAGAACGTTGGGAAGACGAGCAATATCTTTGGGCTGCAGAGGATC
  TTCCCAGCCGGCTCCATTCCCCTAACCAGGCCAGCCCATTCCACTTCAGTGTCCATGTCC
  AGGCTGTCACTGCCCTCCAAAAATGGTTCAAAGAAGAAAGGCCTGAAGCCCAAGGAACTC
  TTCAAGAAGGCAGAGCGAAAGGGCAAGGAGAGTTCAGCCTTGGGGCCTGCTGGCCAGTTG
  AGCTATAATCTCATGGACACATACAGTCATCAGGCACTGAAGACAGGCTCTTTCCAGAAA
  GCAAAGTTCAACATCACTGGTGCCTGCTTGAATGACTCAGATGACGACTCACCAGACTTG
  GACCTTGATGGAAATGAGAGCCCATTGGCCCTATTGATGTCTAACGGCAGTACGAAAAGG
  GTGAAGAGTTTATCCAAATCTCGGCGAACCAAGATAGCAAAGAAGGTAGACAAGGCTAGG
  CTGATGGCAGAACAGGTGATGGAAGACGAATTTGACTTGGATTCAGATGATGAGCTGCAG
  ATTGACGAGAGATTGGGAAAGGAGAAGGCGACCCTGATAATAAGACCAAAATTTCCCCGG
  AAATTGCCCCGTGCGAAGCCTTGCTCTGACCCCAACCGAGTTCGTGAACCAGGAGAAGTT
  GAGTTTGACATTGAGGAGGACTATACAACAGATGAGGACATGGTGGAAGGGGTTGAAGGC
  TATCAGACAGCAACCCCCGCTCCCGCCCAAGGTGCCAGCGAGGCCCCAGCTTCTCCCAGC
  ACTCAGGAGGCCATCCAGGGCATGCTGTGCATGGCCAACCTGCAGTCCTCATCGTCCTCA
  CCGGCTACCTCTAGCCTGCAGGCCTGGTGGACTGGGGGACAGGATCGAAGCAGTGGGAGC
  TCCAGCAGTGGGCTGGGCACAGTGTCTAACAGTCCTGCTTCCCAGCGCACCCCAGGGAAG
  CGGCCCATCAAGCGGCCAGCATACTGGAGAACCGAGAGCGAGGAGGAGGAGGAGAACGCC
  AGTCTGGATGAACAGGACAGCTTGGGAGCGTGCTTCAAGGATGCAGAGTATATCTATCCT
  TCACTGGAGTCTGATGATGATGACCCTGCTTTGAAATCTCGACCCAAGAAAAAGAAGAAT
  TCAGATGATGCTCCATGGAGTCCTAAAGCCCGCGTGACCCCAACTCTGCCGAAGCAGGAC
  CGTCCTGTGCGTGAGGGGACCCGGGTAGCCTCTATTGAGACAGGTTTGGCTGCAGCAGCT
  GCAAAGCTGGCCCAGCAGGTGAAGAAAATGAAGCTCTCATTAACTGACTCAGGATAA
  
• Restriction Sites: Please inquire
• ACCN: NM_001184898
• ORF Size: 2637 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001184898.1, NP_001171827.1
• RefSeq Size: 3580
• RefSeq ORF: 2637
• Locus ID: 23133
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
  Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter N-terminus and a shorter and distinct C-terminus compared to isoform 1.