NALP2 (NLRP2) (NM_001174083) Human Untagged Clone

CAT#: SC329265

NLRP2 (untagged)-Human NLR family pyrin domain containing 2 (NLRP2) transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NLRP2
• Synonyms: CLR19.9; NALP2; NBS1; PAN1; PYPAF2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001174083, the custom clone sequence may differ by one or more nucleotides
  ATGGTGTCTTCGGCGCAGATGGGCTTCAACCTGCAGGCTCTCCTGGAGCAGCTCAGCCAG
  GATGAGTTGAGCAAGTTCAAGTATCTGATCACGACCTTCTCCCTGGCACACGAGCTCCAG
  AAGATCCCCCACAAGGAGATGGCGAGCCTCCAGGTCTTTGAAAAGATGCACCGAATGGAT
  CTGTCTGAGAGAGCAAAGGATGAAGTCAGAGAAGCAGCTTTGAAATCCTTTAATAAAAGG
  AAGCCTCTATCATTAGGGATAACACGGAAAGAACGACCACCTCTAGACGTGGACGAAATG
  CTGGAGCGCTTCAAAACAGAAGCACAAGCGTTTACAGAAACGAAAGGAAATGTCATCTGC
  CTGGGTAAAGAAGTCTTTAAAGGAAAAAAGCCAGACAAAGACAATAGGTGCAGGTATATA
  TTGAAGACGAAGTTCCGGGAGATGTGGAAGAGCTGGCCTGGAGATAGCAAAGAGGTCCAG
  GTTATGGCTGAGAGATACAAGATGCTGATCCCATTCAGCAACCCCAGGGTGCTTCCCGGG
  CCCTTCTCATACACGGTGGTGCTGTATGGTCCTGCAGGCCTTGGGAAAACCACGCTGGCC
  CAGAAACTAATGCTAGACTGGGCAGAGGACAACCTCATCCACAAATTCAAATATGCGTTC
  TACCTCAGCTGCAGGGAGCTCAGCCGCCTGGGCCCGTGCAGTTTTGCAGAGCTGGTCTTC
  AGGGACTGGCCTGAATTGCAGGATGACATTCCACACATCCTAGCCCAAGCACGGAAAATC
  TTGTTCGTGATTGACGGCTTTGATGAGCTGGGAGCCGCACCTGGGGCGCTGATCGAGGAC
  ATCTGCGGGGACTGGGAGAAGAAGAAGCCGGTGCCCGTCCTCCTGGGGAGTTTGCTGAAC
  AGGGTGATGTTACCCAAGGCCGCCCTGCTGGTCACCACGCGGCCCAGGGCCCTGAGGGAC
  CTCCGGATCCTGGCGGAGGAGCCGATCTACATAAGGGTGGAGGGCTTCCTGGAGGAGGAC
  AGGAGGGCCTATTTCCTGAGACACTTTGGAGACGAGGACCAAGCCATGCGTGCCTTTGAG
  CTAATGAGGAGCAACGCGGCCCTGTTCCAGCTGGGCTCGGCCCCCGCGGTGTGCTGGATC
  GTGTGCACGACTCTGAAGCTGCAGATGGAGAAGGGGGAGGACCCGGTCCCCACCTGCCTC
  ACCCGCACGGGGCTGTTCCTGCGTTTCCTCTGCAGCCGGTTCCCGCAGGGCGCACAGCTG
  CGGGGCGCGCTGCGGACGCTGAGCCTCCTGGCCGCGCAGGGCCTGTGGGCGCAGACGTCC
  GTGCTTCACCGAGAGGATCTGGAAAGGCTCGGGGTGCAGGAGTCCGACCTCCGTCTGTTC
  CTGGACGGAGACATCCTCCGCCAGGACAGAGTCTCCAAAGGCTGCTACTCCTTCATCCAC
  CTCAGCTTCCAGCAGTTTCTCACTGCCCTGTTCTACACCCTGGAGAAGGAGGAGGAAGAG
  GATAGGGACGGCCACACCTGGGACATTGGGGACGTACAGAAGCTGCTTTCCGGAGTAGAA
  AGACTCAGGAACCCCGACCTGATCCAAGCAGGCTACTACTCCTTTGGCCTCGCTAACGAG
  AAGAGAGCCAAGGAGTTGGAGGCCACTTTTGGCTGCCGGATGTCACCGGACATCAAACAG
  GAATTGCTGCGATGCGACATAAGTTGTAAGGGTGGACATTCAACGGTGACAGACCTGCAG
  GAGCTCCTCGGCTGTCTGTACGAGTCTCAGGAGGAGGAGCTGGTGAAGGAGGTGATGGCT
  CAGTTCAAAGAAATATCCCTGCACTTAAATGCAGTAGACGTTGTGCCATCTTCATTCTGC
  GTCAAGCACTGTCGAAACCTGCAGAAAATGTCACTGCAGGTAATAAAGGAGAATCTCCCG
  GAGAATGTCACTGCGTCTGAATCAGACGCCGAGGTTGAGAGATCCCAGGATGATCAGCAC
  ATGCTTCCTTTCTGGACGGACCTTTGTTCCATATTTGGATCAAATAAGGATCTGATGGGT
  CTAGCAATCAATGATAGCTTTCTCAGTGCCTCCCTAGTAAGGATCCTGTGTGAACAAATA
  GCCTCTGACACCTGTCATCTCCAGAGAGTGGTGTTCAAAAACATTTCCCCAGCTGATGCT
  CATCGGAACCTCTGCCTAGCTCTTCGAGGTCACAAGACTGTAACGTATCTGACCCTTCAA
  GGCAATGACCAGGATGATATGTTTCCCGCATTGTGTGAGGTCTTGAGACATCCAGAATGT
  AACCTGCGATATCTCGGGTTGGTGTCTTGTTCCGCTACCACTCAGCAGTGGGCTGATCTC
  TCCTTGGCCCTTGAAGTCAACCAGTCCCTGACGTGCGTAAACCTCTCCGACAATGAGCTT
  CTGGATGAGGGTGCTAAGTTGCTGTACACAACTTTGAGACACCCCAAGTGCTTTCTGCAG
  AGGTTGTCGTTGGAAAACTGTCACCTTACAGAAGCCAATTGCAAGGACCTTGCTGCTGTG
  TTGGTTGTCAGCCGGGAGCTGACACACCTGTGCTTGGCCAAGAACCCCATTGGGAATACA
  GGGGTGAAGTTTCTGTGTGAGGGCTTGAGGTACCCCGAGTGTAAACTGCAGACCTTGGTG
  CTTTGGAACTGCGACATAACTAGCGATGGCTGCTGCGATCTCACAAAGCTTCTCCAAGAA
  AAATCAAGCCTGTTGTGTTTGGATCTGGGGCTGAATCACATAGGAGTTAAGGGAATGAAG
  TTCCTGTGTGAGGCTTTGAGGAAACCACTGTGCAACTTGAGATGTCTGTGGTTGTGGGGA
  TGTTCCATCCCTCCGTTCAGTTGTGAAGACCTCTGCTCTGCCCTCAGCTGCAACCAGAGC
  CTCGTCACTCTGGACCTGGGTCAGAATCCCTTGGGGTCTAGTGGAGTGAAGATGCTGTTT
  GAAACCTTGACATGTTCCAGTGGCACCCTCCGGACACTCAGGTTGAAAATCGATGACTTT
  AATGATGAACTCAATAAGCTGCTGGAAGAAATAGAAGAAAAAAACCCACAACTGATTATT
  GATACTGAGAAACATCATCCCTGGGCAGAAAGGCCTTCTTCTCATGACTTCATGATCTGA
  
• Restriction Sites: Please inquire
• ACCN: NM_001174083
• ORF Size: 3120 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001174083.1, NP_001167554.1
• RefSeq Size: 3521
• RefSeq ORF: 3120
• Locus ID: 55655
• Gene Summary: This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
  Transcript Variant: This variant (4) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.