PHF8 (NM_001184896) Human Untagged Clone

CAT#: SC329271

PHF8 (untagged)-Human PHD finger protein 8 (PHF8) transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PHF8
• Synonyms: JHDM1F; KDM7B; MRXSSD; ZNF422
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001184896, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGAACAGGAGCCGCGCTATCGTCCAGAGAGGACGCGTGCTGCCGCCTCCCGCCCCTCTTGACACGACGA
  ACCTGGCCGGCCGCAGAACGCTCCAGGGCCGAGCGAAGATGGCCTCGGTGCCGGTGTATTGCCTCTGCCG
  GCTGCCTTACGATGTGACCCGCTTCATGATCGAGTGTGACATGTGCCAGGACTGGTTTCATGGCAGTTGT
  GTTGGTGTTGAAGAGGAGAAGGCTGCTGACATTGACCTCTACCACTGCCCCAACTGTGAAGTCTTGCATG
  GGCCCTCCATTATGAAAAAACGCCGTGGATCTTCAAAGGGGCATGATACACACAAGGGGAAACCAGTGAA
  GACCGGGAGCCCTACGTTCGTCAGAGAGCTCCGGAGTAGGACTTTTGACAGCTCAGATGAAGTGATTCTG
  AAGCCCACTGGAAATCAACTGACCGTGGAATTCCTGGAAGAAAATAGCTTCAGTGTGCCCATCCTGGTCC
  TGAAGAAGGATGGGTTGGGCATGACGCTGCCCTCGCCATCATTCACTGTGAGGGATGTTGAACACTATGT
  TGGTTCTGACAAAGAGATTGATGTGATTGATGTGACCCGCCAGGCTGACTGCAAGATGAAGCTTGGTGAT
  TTTGTGAAATACTATTACAGCGGGAAGAGGGAGAAAGTCCTCAATGTCATTAGTTTGGAATTCTCTGATA
  CCAGACTTTCTAACCTTGTGGAGACACCGAAGATTGTTCGAAAGCTGTCATGGGTCGAAAACTTGTGGCC
  AGAGGAATGTGTCTTTGAGAGACCCAATGTACAGAAGTACTGCCTCATGAGTGTGCGAGATAGCTATACA
  GACTTTCACATTGACTTTGGTGGCACCTCTGTCTGGTACCATGTACTCAAGGGTGAAAAGATCTTCTACC
  TGATCCGCCCAACAAATGCCAATCTGACTCTCTTTGAGTGCTGGAGCAGTTCCTCTAATCAGAATGAGAT
  GTTCTTTGGGGACCAGGTGGACAAGTGCTACAAGTGTTCCGTGAAGCAAGGACAGACACTTTTCATTCCC
  ACAGGGTGGATCCATGCTGTGCTGACGCCTGTGGACTGCCTTGCCTTTGGAGGGAACTTCTTACACAGCC
  TTAACATCGAGATGCAGCTCAAAGCCTATGAGATTGAGAAGCGGCTGAGCACAGCAGACCTCTTCAGATT
  CCCCAACTTTGAGACCATCTGTTGGTATGTGGGAAAGCACATCCTGGACATCTTTCGCGGTTTGCGAGAG
  AACAGGAGACACCCTGCCTCCTACCTGGTCCATGGTGGCAAAGCCTTGAACTTGGCCTTTAGAGCCTGGA
  CAAGGAAAGAAGCTCTGCCAGACCATGAGGATGAGATCCCGGAGACAGTGCGAACCGTACAGCTCATTAA
  AGATCTGGCCAGGGAGATCCGCCTGGTGGAAGACATCTTCCAACAGAACGTTGGGAAGACGAGCAATATC
  TTTGGGCTGCAGAGGATCTTCCCAGCCGGCTCCATTCCCCTAACCAGGCCAGCCCATTCCACTTCAGTGT
  CCATGTCCAGGCTGTCACTGCCCTCCAAAAATGGTTCAAAGAAGAAAGGCCTGAAGCCCAAGGAACTCTT
  CAAGAAGGCAGAGCGAAAGGGCAAGGAGAGTTCAGCCTTGGGGCCTGCTGGCCAGTTGAGCTATAATCTC
  ATGGACACATACAGTCATCAGGCACTGAAGACAGGCTCTTTCCAGAAAGCAAAGTTCAACATCACTGGTG
  CCTGCTTGAATGACTCAGATGACGACTCACCAGACTTGGACCTTGATGGAAATGAGAGCCCATTGGCCCT
  ATTGATGTCTAACGGCAGTACGAAAAGGGTGAAGAGTTTATCCAAATCTCGGCGAACCAAGATAGCAAAG
  AAGGTAGACAAGGCTAGGCTGATGGCAGAACAGGTGATGGAAGACGAATTTGACTTGGATTCAGATGATG
  AGCTGCAGATTGACGAGAGATTGGGAAAGGAGAAGGCGACCCTGATAATAAGACCAAAATTTCCCCGGAA
  ATTGCCCCGTGCGAAGCCTTGCTCTGACCCCAACCGAGTTCGTGAACCAGGAGAAGTTGAGTTTGACATT
  GAGGAGGACTATACAACAGATGAGGACATGGTGGAAGGGGTTGAAGGCAAGCTTGGGAATGGTAGTGGCG
  CTGGTGGCATTCTTGATCTGCTCAAGGCCAGCAGGCAGGTGGGGGGACCTGACTATGCTGCCCTCACCGA
  GGCCCCAGCTTCTCCCAGCACTCAGGAGGCCATCCAGGGCATGCTGTGCATGGCCAACCTGCAGTCCTCA
  TCGTCCTCACCGGCTACCTCTAGCCTGCAGGCCTGGTGGACTGGGGGACAGGATCGAAGCAGTGGGAGCT
  CCAGCAGTGGGCTGGGCACAGTGTCTAACAGTCCTGCTTCCCAGCGCACCCCAGGGAAGCGGCCCATCAA
  GCGGCCAGCATACTGGAGAACCGAGAGCGAGGAGGAGGAGGAGAACGCCAGTCTGGATGAACAGGACAGC
  TTGGGAGCGTGCTTCAAGGATGCAGAGTATATCTATCCTTCACTGGAGTCTGATGATGATGACCCTGCTT
  TGAAATCTCGACCCAAGAAAAAGAAGAATTCAGATGATGCTCCATGGAGTCCTAAAGCCCGCGTGACCCC
  AACTCTGCCGAAGCAGGACCGTCCTGTGCGTGAGGGGACCCGGGTAGCCTCTATTGAGACAGGTTTGGCT
  GCAGCAGCTGCAAAGCTGGCCCAGCAGGAGCTACAGAAGGCCCAAAAGAAGAAATATATCAAGAAGAAGC
  CTTTGCTGAAGGAGGTAGAACAGCCTCGCCCTCAAGACTCCAATCTCAGTCTGACAGTACCAGCCCCCAC
  TGTGGCTGCCACACCACAACTTGTCACCTCCTCCTCACCCCTGCCTCCTCCTGAGCCTAAACAAGAGGCC
  CTGTCAGGAAGTCTCGCTGACCATGAGTACACCGCTCGTCCCAATGCCTTTGGCATGGCCCAGGCAAACC
  GCAGCACCACACCTATGGCCCCCGGTGTCTTCTTGACCCAGCGGCGCCCTTCAGTTGGCTCCCAGAGCAA
  TCAGGCAGGACAAGGAAAGCGTCCCAAAAAGGGCCTGGCCACAGCAAAGCAGAGACTCGGCCGTATCCTG
  AAAATCCACAGAAATGGCAAACTACTTCTGTGA
  
  
• Restriction Sites: SgfI-RsrII
• ACCN: NM_001184896
• ORF Size: 3183 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001184896.1, NP_001171825.1
• RefSeq Size: 5921
• RefSeq ORF: 3183
• Locus ID: 23133
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
  Transcript Variant: This variant (1) encodes the longest isoform (1).