NALP2 (NLRP2) (NM_001174081) Human Untagged Clone

CAT#: SC329274

NLRP2 (untagged)-Human NLR family pyrin domain containing 2 (NLRP2) transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NLRP2
• Synonyms: CLR19.9; NALP2; NBS1; PAN1; PYPAF2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001174081, the custom clone sequence may differ by one or more nucleotides
  ATGGTGTCTTCGGCGCAGATGGGCTTCAACCTGCAGGCTCTCCTGGAGCAGCTCAGCCAG
  GATGAGTTGAGCAAGTTCAAGTATCTGATCACGACCTTCTCCCTGGCACACGAGCTCCAG
  AAGATCCCCCACAAGGAGGTAGACAAGGCTGATGGGAAGCAACTGGTAGAAATCCTCACC
  ACCCATTGTGACAGCTACTGGGTGGAGATGGCGAGCCTCCAGGTCTTTGAAAAGATGCAC
  CGAATGGATCTGTCTGAGAGAGCAAAGGATGAAGTCAGAGAAGCAGCTTTGAAATCCTTT
  AATAAAAGGAAGCCTCTATCATTAGGGATAACACGGAAAGAACGACCACCTCTAGACGTG
  GACGAAATGCTGGAGCGCTTCAAAACAGAAGCACAAGCGTTTACAGAAACGAAAGGAAAT
  GTCATCTGCCTGGGTAAAGAAGTCTTTAAAGGAAAAAAGCCAGACAAAGACAATAGGTGC
  AGGTATATATTGAAGACGAAGTTCCGGGAGATGTGGAAGAGCTGGCCTGGAGATAGCAAA
  GAGGTCCAGGTTATGGCTGAGAGATACAAGATGCTGATCCCATTCAGCAACCCCAGGGTG
  CTTCCCGGGCCCTTCTCATACACGGTGGTGCTGTATGGTCCTGCAGGCCTTGGGAAAACC
  ACGCTGGCCCAGAAACTAATGCTAGACTGGGCAGAGGACAACCTCATCCACAAATTCAAA
  TATGCGTTCTACCTCAGCTGCAGGGAGCTCAGCCGCCTGGGCCCGTGCAGTTTTGCAGAG
  CTGGTCTTCAGGGACTGGCCTGAATTGCAGGATGACATTCCACACATCCTAGCCCAAGCA
  CGGAAAATCTTGTTCGTGATTGACGGCTTTGATGAGCTGGGAGCCGCACCTGGGGCGCTG
  ATCGAGGACATCTGCGGGGACTGGGAGAAGAAGAAGCCGGTGCCCGTCCTCCTGGGGAGT
  TTGCTGAACAGGGTGATGTTACCCAAGGCCGCCCTGCTGGTCACCACGCGGCCCAGGGCC
  CTGAGGGACCTCCGGATCCTGGCGGAGGAGCCGATCTACATAAGGGTGGAGGGCTTCCTG
  GAGGAGGACAGGAGGGCCTATTTCCTGAGACACTTTGGAGACGAGGACCAAGCCATGCGT
  GCCTTTGAGCTAATGAGGAGCAACGCGGCCCTGTTCCAGCTGGGCTCGGCCCCCGCGGTG
  TGCTGGATCGTGTGCACGACTCTGAAGCTGCAGATGGAGAAGGGGGAGGACCCGGTCCCC
  ACCTGCCTCACCCGCACGGGGCTGTTCCTGCGTTTCCTCTGCAGCCGGTTCCCGCAGGGC
  GCACAGCTGCGGGGCGCGCTGCGGACGCTGAGCCTCCTGGCCGCGCAGGGCCTGTGGGCG
  CAGACGTCCGTGCTTCACCGAGAGGATCTGGAAAGGCTCGGGGTGCAGGAGTCCGACCTC
  CGTCTGTTCCTGGACGGAGACATCCTCCGCCAGGACAGAGTCTCCAAAGGCTGCTACTCC
  TTCATCCACCTCAGCTTCCAGCAGTTTCTCACTGCCCTGTTCTACACCCTGGAGAAGGAG
  GAGGAAGAGGATAGGGACGGCCACACCTGGGACATTGGGGACGTACAGAAGCTGCTTTCC
  GGAGTAGAAAGACTCAGGAACCCCGACCTGATCCAAGCAGGCTACTACTCCTTTGGCCTC
  GCTAACGAGAAGAGAGCCAAGGAGTTGGAGGCCACTTTTGGCTGCCGGATGTCACCGGAC
  ATCAAACAGGAATTGCTGCGATGCGACATAAGTTGTAAGGGTGGACATTCAACGGTGACA
  GACCTGCAGGAGCTCCTCGGCTGTCTGTACGAGTCTCAGGAGGAGGAGCTGGTGAAGGAG
  GTGATGGCTCAGTTCAAAGAAATATCCCTGCACTTAAATGCAGTAGACGTTGTGCCATCT
  TCATTCTGCGTCAAGCACTGTCGAAACCTGCAGAAAATGTCACTGCAGGTAATAAAGGAG
  AATCTCCCGGAGAATGTCACTGCGTCTGAATCAGACGCCGAGGTTGAGAGATCCCAGGAT
  GATCAGCACATGCTTCCTTTCTGGACGGACCTTTGTTCCATATTTGGATCAAATAAGGAT
  CTGATGGGTCTAGCAATCAATGATAGCTTTCTCAGTGCCTCCCTAGTAAGGATCCTGTGT
  GAACAAATAGCCTCTGACACCTGTCATCTCCAGAGAGTGGTGTTCAAAAACATTTCCCCA
  GCTGATGCTCATCGGAACCTCTGCCTAGCTCTTCGAGGTCACAAGACTGTAACGTATCTG
  ACCCTTCAAGGCAATGACCAGGATGATATGTTTCCCGCATTGTGTGAGGTCTTGAGACAT
  CCAGAATGTAACCTGCGATATCTCGGGTTGGTGTCTTGTTCCGCTACCACTCAGCAGTGG
  GCTGATCTCTCCTTGGCCCTTGAAGTCAACCAGTCCCTGACGTGCGTAAACCTCTCCGAC
  AATGAGCTTCTGGATGAGGGTGCTAAGTTGCTGTACACAACTTTGAGACACCCCAAGTGC
  TTTCTGCAGAGGTTGTCGTTGGAAAACTGTCACCTTACAGAAGCCAATTGCAAGGACCTT
  GCTGCTGTGTTGGTTGTCAGCCGGGAGCTGACACACCTGTGCTTGGCCAAGAACCCCATT
  GGGAATACAGGGGTGAAGTTTCTGTGTGAGGGCTTGAGGTACCCCGAGTGTAAACTGCAG
  ACCTTGGTGCTTTGGAACTGCGACATAACTAGCGATGGCTGCTGCGATCTCACAAAGCTT
  CTCCAAGAAAAATCAAGCCTGTTGTGTTTGGATCTGGGGCTGAATCACATAGGAGTTAAG
  GGAATGAAGTTCCTGTGTGAGGCTTTGAGGAAACCACTGTGCAACTTGAGATGTCTGTGG
  TTGTGGGGATGTTCCATCCCTCCGTTCAGTTGTGAAGACCTCTGCTCTGCCCTCAGCTGC
  AACCAGAGCCTCGTCACTCTGGACCTGGGTCAGAATCCCTTGGGGTCTAGTGGAGTGAAG
  ATGCTGTTTGAAACCTTGACATGTTCCAGTGGCACCCTCCGGACACTCAGGTTGAAAATC
  GATGACTTTAATGATGAACTCAATAAGCTGCTGGAAGAAATAGAAGAAAAAAACCCACAA
  CTGATTATTGATACTGAGAAACATCATCCCTGGGCAGAAAGGCCTTCTTCTCATGACTTC
  ATGATCTGA
  
• Restriction Sites: Please inquire
• ACCN: NM_001174081
• ORF Size: 3189 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001174081.1, NP_001167552.1
• RefSeq Size: 3560
• RefSeq ORF: 3189
• Locus ID: 55655
• Gene Summary: This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).