SESN1 (NM_001199933) Human Untagged Clone

CAT#: SC329595

SESN1 (untagged) - Homo sapiens sestrin 1 (SESN1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SESN1
• Synonyms: PA26; SEST1
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001199933, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCGCTTGGCCGCCGCCGCGAACGAGGCGTACACGGCCCCTTTGGCGGTCTCGGGGCTGCTGGGCTGCA
  AGCAGTGCGGCGGGGGCCGCGACCAGGACGAGGAACTTGGCATTAGAATTCCTCGACCACTAGGACAGGG
  ACCAAGCAGATTCATCCCAGAAAAGGAGATCCTCCAAGTGGGGAGTGAAGACGCACAGATGCATGCTTTA
  TTTGCAGATTCTTTTGCTGCTTTGGGCCGTTTGGATAACATTACGTTAGTGATGGTTTTCCACCCACAAT
  ATTTAGAAAGTTTCTTAAAAACTCAGCACTATCTACTGCAAATGGATGGGCCGTTACCCCTACATTATCG
  TCACTACATTGGAATAATGGCTGCGGCAAGACATCAGTGCTCCTACTTAGTGAACCTGCATGTAAATGAT
  TTCCTTCATGTTGGTGGGGACCCCAAGTGGCTCAATGGTTTAGAGAATGCTCCTCAAAAACTACAGAATT
  TAGGAGAACTTAACAAAGTGTTAGCCCATAGACCTTGGCTTATTACCAAAGAACACATTGAGGGACTTTT
  AAAAGCTGAAGAGCACAGCTGGTCCCTTGCGGAATTGGTACATGCAGTAGTTTTACTCACACACTATCAT
  TCTCTTGCCTCATTCACATTCGGCTGTGGAATCAGTCCAGAAATTCATTGTGATGGTGGCCACACATTCA
  GACCTCCTTCTGTTAGCAACTACTGCATCTGTGACATTACAAATGGCAATCACAGTGTGGATGAGATGCC
  GGTCAACTCAGCAGAAAATGTTTCTGTAAGTGATTCTTTCTTTGAGGTTGAAGCCCTCATGGAAAAGATG
  AGGCAGTTACAGGAATGTCGAGATGAAGAAGAGGCAAGTCAGGAAGAGATGGCTTCACGTTTTGAAATAG
  AAAAAAGAGAGAGTATGTTTGTCTTCTCTTCAGATGATGAAGAAGTTACACCAGCAAGAGCTGTATCTCG
  TCATTTTGAGGATACTAGTTATGGCTATAAAGATTTCTCTAGACATGGGATGCATGTTCCAACATTTCGT
  GTCCAGGACTATTGCTGGGAAGATCATGGTTATTCTTTGGTAAATCGCCTTTATCCAGATGTGGGACAGT
  TGATTGATGAAAAATTTCACATTGCTTACAATCTTACTTATAATACAATGGCAATGCACAAAGATGTTGA
  TACCTCAATGCTTAGACGGGCAATTTGGAACTATATTCACTGCATGTTTGGAATAAGATATGATGATTAT
  GACTATGGTGAAATTAACCAGCTATTGGATCGTAGCTTTAAAGTTTATATCAAAACTGTTGTTTGCACTC
  CTGAAAAGGTTACCAAAAGAATGTATGATAGCTTCTGGAGGCAGTTCAAGCACTCTGAGAAGGTTCATGT
  TAATCTGCTTCTTATAGAAGCTAGGATGCAAGCAGAACTCCTTTATGCTCTGAGAGCCATTACCCGCTAT
  ATGACCTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001199933
• ORF Size: 1479 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_001199933.1, NP_001186862.1
• RefSeq Size: 2698
• RefSeq ORF: 1479
• Locus ID: 27244
• Protein Pathways: p53 signaling pathway
• Gene Summary: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
  Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.