HCP1 (SLC46A1) (NM_001242366) Human Untagged Clone

CAT#: SC329938

SLC46A1 (untagged) - Homo sapiens solute carrier family 46 (folate transporter), member 1 (SLC46A1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SLC46A1
• Synonyms: G21; HCP1; PCFT
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001242366, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAGGGGAGCGCGAGCCCCCCGGAAAAGCCCCGCGCCCGCCCTGCGGCTGCCGTGCTGTGCCGGGGCC
  CGGTAGAGCCGCTGGTCTTCCTGGCCAACTTTGCCTTGGTCCTGCAGGGCCCGCTCACCACGCAGTATCT
  GTGGCACCGCTTCAGCGCCGACCTCGGCTACAATGGCACCCGCCAAAGGGGGGGCTGCAGCAACCGCAGC
  GCGGACCCCACCATGCAGGAAGTGGAGACCCTTACCTCCCACTGGACCCTCTACATGAACGTGGGCGGCT
  TCCTGGTGGGGCTCTTCTCGTCCACCCTGCTGGGAGCTTGGAGCGACAGTGTGGGCCGCCGCCCGCTGCT
  AGTGCTGGCCTCGCTGGGCCTGCTGCTCCAGGCCCTAGTGTCCGTTTTTGTGGTGCAGCTGCAGCTCCAC
  GTCGGCTACTTCGTGCTGGGTCGCATCCTTTGTGCCCTCCTCGGCGACTTCGGTGGCCTTCTGGCTGCTA
  GCTTTGCGTCCGTGGCAGATGTCAGCTCCAGTCGCAGCCGCACCTTCCGGATGGCCCTGCTGGAAGCCAG
  CATCGGGGTGGCTGGGATGCTGGCAAGCCTCCTCGGGGGCCACTGGCTCCGGGCCCAGGGTTATGCCAAC
  CCCTTCTGGCTGGCCTTGGCCTTGCTGATAGCCATGACTCTCTATGCAGCTTTCTGCTTTGGTGAGACCT
  TAAAGGAGCCAAAGTCCACCCGGCTCTTCACGTTCCGTCACCACCGATCCATTGTCCAGCTCTATGTGGC
  TCCCGCCCCAGAGAAGTCCAGGAAACATTTAGCCCTCTACTCACTGGCCATCTTCGTGGTGATCACTGTG
  CACTTTGGGGCCCAGGACATCTTAACCCTTTATGAACTAAGCACACCCCTCTGCTGGGACTCCAAACTAA
  TCGGCTATGGTTCTGCAGCTCAGCATCTCCCCTACCTCACCAGCCTGCTGGCCCTGAAGCTCCTGCAGTA
  CTGCCTGGCCGATGCCTGGGTAGCTGAGATCGGCCTGGCCTTCAACATCCTGGGGATGGTGGTCTTTGCC
  TTTGCCACTATCACGCCTCTCATGTTCACAGGTGCTCTCTTTTCTGCTGTGGCCTGTGTGAATAGCCTGG
  CCATGCTGACGGCCTCCGGCATCTTCAACTCACTCTACCCAGCCACTCTGAACTTTATGAAGGGGTTCCC
  CTTCCTCCTGGGAGCTGGCCTCCTGCTCATCCCGGCTGTTCTGATTGGGATGCTGGAAAAGGCTGATCCT
  CACCTCGAGTTCCAGCAGTTTCCCCAGAGCCCCTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001242366
• ORF Size: 1296 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001242366.2, NP_001229295.1
• RefSeq Size: 6426
• RefSeq ORF: 1296
• Locus ID: 113235
• Protein Families: Transmembrane
• Gene Summary: This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]
  Transcript Variant: This variant (2, also known as HCP-1B) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment (containing one of the transmembrane domains) compared to isoform 1. This isoform was shown to have a different subcellular localization compared to the longer isoform 1 (PMID:17947394).