USP2 (NM_001243759) Human Untagged Clone

CAT#: SC330173

USP2 (untagged) - Homo sapiens ubiquitin specific peptidase 2 (USP2), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: USP2
• Synonyms: UBP41; USP9
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001243759, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCTTGTGCCCGGTTCGACTCGTCCATACTCCAAGAAGAGGCAGAATTCTAAGAGTGCCCAGGGTCTGG
  CTGGTCTTCGAAACCTTGGGAACACGTGCTTCATGAACTCAATTCTGCAGTGCCTGAGCAACACTCGGGA
  GTTGAGAGATTACTGCCTCCAGAGGCTCTACATGCGGGACCTGCACCACGGCAGCAATGCACACACAGCC
  CTCGTGGAAGAGTTTGCAAAACTAATTCAGACCATATGGACTTCATCCCCCAATGATGTGGTGAGCCCAT
  CTGAGTTCAAGACCCAGATCCAGAGATACGCACCGCGCTTTGTTGGCTATAATCAGCAGGATGCTCAGGA
  GTTCCTTCGCTTTCTTCTGGATGGGCTCCATAACGAGGTGAACCGAGTGACACTGAGACCTAAGTCCAAC
  CCTGAGAACCTCGATCATCTTCCTGATGACGAGAAAGGCCGACAGATGTGGAGAAAATATCTAGAACGGG
  AAGACAGTAGGATCGGGGATCTCTTTGTTGGGCAGCTAAAGAGCTCGCTGACGTGTACAGATTGTGGTTA
  CTGTTCTACGGTCTTCGACCCCTTCTGGGACCTCTCACTGCCCATTGCTAAGCGAGGTTATCCTGAGGTG
  ACATTAATGGACTGCATGAGGCTCTTCACCAAAGAGGATGTGCTTGATGGAGATGAAAAGCCAACATGCT
  GTCGCTGCCGAGGCAGAAAACGGTGTATAAAGAAGTTCTCCATCCAGAGGTTCCCAAAGATCTTGGTGCT
  CCATCTGAAGCGGTTCTCAGAATCCAGGATCCGAACCAGCAAGCTCACAACATTTGTGAACTTCCCCCTA
  AGAGACCTGGACTTAAGAGAATTTGCCTCAGAAAACACCAACCATGCTGTTTACAACCTGTACGCTGTGT
  CCAATCACTCCGGAACCACCATGGGTGGCCACTATACAGCCTACTGTCGCAGTCCAGGGACAGGAGAATG
  GCACACTTTCAACGACTCCAGCGTCACTCCCATGTCCTCCAGCCAAGTGCGCACCAGCGACGCCTACCTG
  CTCTTCTACGAACTGGCCAGCCCGCCCTCCCGAATGTAG
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001243759
• ORF Size: 1089 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001243759.1, NP_001230688.1
• RefSeq Size: 2933
• RefSeq ORF: 1089
• Locus ID: 9099
• Protein Families: Protease
• Gene Summary: This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
  Transcript Variant: This variant (3) lacks an internal exon in the 5' region, compared to variant 1. The resulting isoform (c) has a shorter and different N-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.