Cellular Apoptosis Susceptibility (CSE1L) (NM_001256135) Human Untagged Clone

CAT#: SC330372

CSE1L (untagged) - Homo sapiens CSE1 chromosome segregation 1-like (yeast) (CSE1L), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CSE1L
• Synonyms: CAS; CSE1; XPO2
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001256135, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAACTCAGCGATGCAAATCTGCAAACACTAACAGAATATTTAAAGAAAACACTTGATCCTGATCCTG
  CCATCCGACGTCCAGCTGAGAAATTTCTTGAATCTGTTGAAGGAAATCAGAATTATCCACTGTTGCTTTT
  GACATTACTGGAGAAGTCCCAGGATAATGTTATCAAAGTATGTGCTTCAGTAACATTCAAAAACTATATT
  AAAAGGAACTGGAGAATTGTTGAAGATGAACCAAACAAAATTTGTGAAGCCGATCGAGTGGCCATTAAAG
  CCAACATAGTGCACTTGATGCTTAGCAGCCCAGAGCAAATTCAGAAGCAGTTAAGTGATGCAATTAGCAT
  TATTGGCAGAGAAGATTTTCCACAGAAATGGCCTGACTTGCTGACAGAAATGGTGAATCGCTTTCAGAGT
  GGAGATTTCCATGTTATTAATGGAGTCCTCCGTACAGCACATTCATTATTTAAAAGATACCGTCATGAAT
  TTAAGTCAAACGAGTTATGGACTGAAATTAAGCTTGTTCTGGATGCCTTTGCTTTGCCTTTGACTAATCT
  TTTTAAGGCCACTATTGAACTCTGCAGTACCCATGCAAATGATGCCTCTGCCCTGAGGATTCTGTTTTCT
  TCCCTGATCCTGATCTCAAAATTGTTCTATAGTTTAAACTTTCAGGATCTCCCTGAATTTTTTGAAGATA
  ATATGGAAACTTGGATGAATAATTTTCATACTCTCTTAACATTGGATAATAAGCTTTTACAAACTGATTT
  GGTAAGTAATGCAATTCAATTTCTGGCTTCAGTTTGTGAGAGACCTCATTATAAGAATCTATTTGAGGAC
  CAGAACACGCTGACAAGTATCTGTGAAAAGGTTATTGTGCCTAACATGGAATTTAGAGCTGCTGATGAAG
  AAGCATTTGAAGATAATTCTGAGGAGTACATAAGGAGAGATTTGGAAGGATCTGATATTGATACTAGACG
  CAGGGCTGCTTGTGATCTGGTACGAGGATTATGCAAGTTTTTTGAGGGACCTGTGACAGGAATCTTCTCT
  GGTTATGTTAATTCCATGCTGCAGGAATACGCAAAAAATCCATCTGTCAACTGGAAACACAAAGATGCAG
  CCATCTACCTAGTGACATCTTTGGCATCAAAAGCCCAAACACAGAAGCATGGAATTACACAAGCAAATGA
  ACTTGTAAACCTAACTGAGTTCTTTGTGAATCACATCCTCCCTGATTTAAAATCAGCTAATGTGAATGAA
  TTTCCTGTCCTTAAAGCTGACGGTATCAAATATATTATGATTTTTAGAAATCAAGTGCCAAAAGAACATC
  TTTTAGTCTCGATTCCTCTCTTGATTAATCATCTTCAAGCTGAAAGTATTGTTGTTCATACTTACGCAGC
  TCATGCTCTTGAACGGCTCTTTACTATGCGAGGGCCTAACAATGCCACTCTCTTTACAGCTGCAGAAATC
  GCACCGTTTGTTGAGATTCTGCTAACAAACCTTTTCAAAGCTCTCACACTTCCTGGCTCTTCAGAAAATG
  AATATATTATGAAAGCTATCATGAGAAGTTTTTCTCTCCTACAAGAAGCCATAATCCCCTACATCCCTAC
  TCTCATCACTCAGCTTACACAGAAGCTATTAGCTGTTAGTAAGAACCCAAGCAAACCTCACTTTAATCAC
  TACATGTTTGAAGCAATATGTTTATCCATAAGAATAACTTGCAAAGCTAACCCTGCTGCTGTTGTAAATT
  TTGAGGAGGCTTTGTTTTTGGTGTTTACTGAAATCTTACAAAATGATGTGCAAGAATTTATTCCATACGT
  CTTTCAAGTGATGTCTTTGCTTCTGGAAACACACAAAAATGACATCCCGTCTTCCTATATGGCCTTATTT
  CCTCATCTCCTTCAGCCAGTGCTTTGGGAAAGAACAGGAAATATTCCTGCTCTAGTGAGGCTTCTTCAAG
  CATTCTTAGAACGCGGTTCAAACACAATAGCAAGTGCTGCAGCTGACAAAATTCCTGGGTTACTAGGTGT
  CTTTCAGAAGCTGATTGCATCCAAAGCAAATGACCACCAAGGTTTTTATCTTCTAAACAGTATAATAGAG
  CACATGCCTCCTGAATCAGTTGACCAATATAGGAAACAAATCTTCATTCTGCTATTCCAGAGACTTCAGA
  ATTCCAAAACAACCAAGTTTATCAAGAGTTTTTTAGTCTTTATTAATTTGTATTGCATAAAATATGGGGC
  ACTAGCACTACAAGAAATATTTGATGGTATACAACCAAAAATGTTTGGAATGGTTTTGGAAAAAATTATT
  ATTCCTGAAATTCAGAAGGTATCTGGAAATGTAGAGAAAAAGATCTGTGCGGTTGGCATAACCAAATTAC
  TAACAGAATGTCCCCCAATGATGGACACTGAGTATACCAAACTGTGGACTCCATTATTACAGTCTTTGAT
  TGGTCTTTTTGAGTTACCCGAAGATGATACCATTCCTGATGAGGAACATTTTATTGACATAGAAGATACA
  CCAGGATATCAGACTGCCTTCTCACAGTTGGCATTTGCTGGGAAAAAAGAGCATGATCCTGTAGGTCAAA
  TGGTGAATAACCCCAAAATTCACCTGGCACAGTCACTTCACAAGTTGTCTACCGCCTGTCCAGGAAGGGT
  TCCATCAATGGTGAGCACCAGCCTGAATGCAGAAGCGCTCCAGTATCTCCAAGGGTACCTTCAGGCAGCC
  AGTGTGACACTGCTTTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001256135
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001256135.1, NP_001243064.1
• RefSeq Size: 3459 bp
• RefSeq ORF: 2748 bp
• Locus ID: 1434
• Cytogenetics: 20q13.13
• Protein Families: Druggable Genome
• Gene Summary: 'Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]'
  Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.