PTPRB (NM_001206972) Human Untagged Clone

CAT#: SC331725

PTPRB (untagged) - Homo sapiens protein tyrosine phosphatase, receptor type, B (PTPRB), transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPRB
• Synonyms: HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001206972, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCTGAGCCATGGAGCCGGGTTGGCCTTGTGGATCACACTGAGCCTGCTGCAGACTGGACTGGCGGAGC
  CAGAGAGATGTAACTTCACCCTGGCGGAGTCCAAGGCCTCCAGCCATTCTGTGTCTATCCAGTGGAGAAT
  TTTGGGCTCACCCTGTAACTTTAGCCTCATCTATAGCAGTGACACCCTGGGGGCCGCGTTGTGCCCTACC
  TTTCGGATAGACAACACCACATACGGATGTAACCTTCAAGATTTACAAGCAGGAACCATCTATAACTTCA
  GGATTATTTCTCTGGATGAAGAGAGAACAGTGGTCTTGCAAACAGATCCTTTACCTCCTGCTAGGTTTGG
  AGTCAGTAAAGAGAAGACGACTTCAACCAGCTTGCATGTTTGGTGGACTCCTTCTTCCGGAAAAGTCACC
  TCATATGAGGTGCAATTATTTGATGAAAATAACCAAAAGATACAGGGGGTTCAAATTCAAGAAAGTACTT
  CATGGAATGAATACACTTTTTTCAATCTCACTGCTGGTAGTAAATACAATATTGCCATCACAGCTGTTTC
  TGGAGGAAAACGTTCTTTTTCAGTTTATACCAATGGATCAACAGTGCCATCTCCAGTGAAAGATATTGGT
  ATTTCCACAAAAGCCAATTCTCTCCTGATTTCCTGGTCCCATGGTTCTGGGAATGTGGAACGATACCGGC
  TGATGCTAATGGATAAAGGGATCCTAGTTCATGGCGGTGTTGTGGACAAACATGCTACTTCCTATGCTTT
  TCACGGGCTGACCCCTGGCTACCTCTACAACCTCACTGTTATGACTGAGGCTGCAGGGCTGCAAAACTAC
  AGGTGGAAACTAGTCAGGACAGCCCCCATGGAAGTCTCAAATCTGAAGGTGACAAATGATGGCAGTTTGA
  CCTCTCTAAAAGTCAAATGGCAAAGACCTCCTGGAAATGTGGATTCTTACAATATCACCCTGTCTCACAA
  AGGGACCATCAAGGAATCCAGAGTATTAGCACCTTGGATTACTGAAACTCACTTTAAAGAGTTAGTCCCC
  GGTCGACTTTATCAAGTTACTGTCAGCTGTGTCTCTGGTGAACTGTCTGCTCAGAAGATGGCAGTGGGCA
  GAACATTTCCAGACAAAGTTGCAAACCTGGAGGCAAACAATAATGGCAGGATGAGGTCTCTTGTAGTGAG
  CTGGTCGCCCCCTGCTGGAGACTGGGAGCAGTATCGGATCCTACTCTTCAATGATTCTGTGGTGCTGCTC
  AACATCACTGTGGGAAAGGAAGAAACACAGTATGTCATGGATGACACGGGGCTCGTACCGGGAAGACAGT
  ATGAGGTGGAAGTCATTGTTGAGAGTGGAAATTTGAAGAATTCTGAGCGTTGCCAAGGCAGGACAGTCCC
  CCTGGCTGTCCTCCAGCTTCGTGTCAAACATGCCAATGAAACCTCACTGAGTATCATGTGGCAGACCCCT
  GTAGCAGAATGGGAGAAATACATCATTTCCCTAGCTGACAGAGACCTCTTACTGATCCACAAGTCACTCT
  CCAAAGATGCCAAAGAATTCACTTTTACTGACCTGGTGCCTGGACGAAAATACATGGCTACAGTCACCAG
  TATTAGTGGAGACTTAAAAAATTCCTCTTCAGTAAAAGGAAGAACAGTGCCTGCCCAAGTGACTGACTTG
  CATGTGGCCAACCAAGGAATGACCAGTAGTCTGTTTACTAACTGGACCCAGGCACAAGGAGACGTAGAAT
  TTTACCAAGTCTTACTGATCCATGAAAATGTGGTCATTAAAAATGAAAGCATCTCCAGTGAGACCAGCAG
  ATACAGCTTCCACTCTCTCAAGTCCGGCAGCCTGTACTCCGTGGTGGTAACAACAGTGAGTGGAGGGATC
  TCTTCCCGACAAGTGGTTGTGGAGGGAAGAACAGTCCCTTCCAGTGTGAGTGGAGTAACGGTGAACAATT
  CCGGTCGTAATGACTACCTCAGCGTTTCCTGGCTGCTGGCGCCCGGAGATGTGGATAACTATGAGGTAAC
  ATTGTCTCATGACGGCAAGGTGGTTCAGTCCCTTGTCATTGCCAAGTCTGTCAGAGAATGTTCCTTCAGC
  TCCCTCACCCCAGGCCGCCTCTACACCGTGACCATAACTACAAGGAGTGGCAAGTATGAAAATCACTCCT
  TCAGCCAAGAGCGGACAGTGCCTGACAAAGTCCAGGGAGTCAGTGTTAGCAACTCAGCCAGGAGTGACTA
  TTTAAGGGTATCCTGGGTGCATGCCACTGGAGACTTTGATCACTATGAAGTCACCATTAAAAACAAAAAC
  AACTTCATTCAAACTAAAAGCATTCCCAAGTCAGAAAACGAATGTGTATTTGTTCAGCTAGTCCCTGGAC
  GGTTGTACAGTGTCACTGTTACTACAAAAAGTGGACAATATGAAGCCAATGAACAAGGGAATGGGAGAAC
  AATTCCAGAGCCTGTTAAGGATCTAACATTGCGCAACAGGAGCACTGAGGACTTGCATGTGACTTGGTCA
  GGAGCTAATGGGGATGTCGACCAATATGAGATCCAGCTGCTCTTCAATGACATGAAAGTATTTCCTCCTT
  TTCACCTTGTAAATACCGCAACCGAGTATCGATTTACTTCCCTAACACCAGGCCGCCAATACAAAATTCT
  TGTCTTGACGATTAGCGGGGATGTACAGCAGTCAGCCTTCATTGAGGGCTTCACAGTTCCTAGTGCTGTC
  AAAAATATTCACATTTCTCCCAATGGAGCAACAGATAGCCTGACGGTGAACTGGACTCCTGGTGGGGGAG
  ACGTTGATTCCTACACGGTGTCGGCATTCAGGCACAGTCAAAAGGTTGACTCTCAGACTATTCCCAAGCA
  CGTCTTTGAGCACACGTTCCACAGACTGGAGGCCGGGGAGCAGTACCAGATCATGATTGCCTCAGTCAGC
  GGGTCCCTGAAGAATCAGATAAATGTGGTTGGGCGGACAGTCCCAGCAGCTGTCACCGACCTGAGGATCA
  CAGAGAACTCCACCAGGCACCTGTCCTTCCGCTGGACCGCCTCAGAGGGGGAGCTCAGCTGGTACAACAT
  CTTTTTGTACAACCCAGATGGGAATCTCCAGGAGAGAGCTCAAGTTGACCCACTAGTCCAGAGCTTCTCT
  TTCCAGAACTTGCTACAAGGCAGAATGTACAAGATGGTGATTGTAACTCACAGTGGGGAGCTGTCTAATG
  AGTCTTTCATATTTGGTAGAACAGTCCCAGCCTCTGTGAGTCATCTCAGGGGGTCCAATCGGAACACGAC
  AGACAGCCTTTGGTTCAACTGGAGTCCAGCCTCTGGGGACTTTGACTTTTATGAGCTGATTCTCTATAAT
  CCCAATGGCACAAAGAAGGAAAACTGGAAAGACAAGGACCTGACGGAGTGGCGGTTTCAAGGCCTTGTTC
  CTGGAAGGAAGTACGTGCTGTGGGTGGTAACTCACAGTGGAGATCTCAGCAATAAAGTCACAGCGGAGAG
  CAGAACAGCTCCAAGTCCTCCCAGTCTTATGTCATTTGCTGACATTGCAAACACATCCTTGGCCATCACG
  TGGAAAGGGCCCCCAGACTGGACAGACTACAACGACTTTGAGCTGCAGTGGTTGCCCAGAGATGCACTTA
  CTGTCTTCAACCCCTACAACAACAGAAAATCAGAAGGACGCATTGTGTATGGTCTTCGTCCAGGGAGATC
  CTATCAATTCAACGTCAAGACTGTCAGTGGTGATTCCTGGAAAACTTACAGCAAACCAATTTTTGGATCT
  GTGAGGACAAAGCCTGACAAGATACAAAACCTGCATTGCCGGCCTCAGAACTCCACGGCCATTGCCTGTT
  CTTGGATCCCTCCTGATTCTGACTTTGATGGTTATAGTATTGAATGCCGGAAAATGGACACCCAAGAAGT
  TGAGTTTTCCAGAAAGCTGGAGAAAGAAAAATCTCTGCTCAACATCATGATGCTAGTGCCCCATAAGAGG
  TACCTGGTGTCCATCAAAGTGCAGTCGGCCGGCATGACCAGCGAGGTGGTTGAAGACAGCACTATCACAA
  TGATAGACCGCCCCCCTCCTCCACCCCCACACATTCGTGTGAATGAAAAGGATGTGCTAATTAGCAAGTC
  TTCCATCAACTTTACTGTCAACTGCAGCTGGTTCAGCGACACCAATGGAGCTGTGAAATACTTCACAGTG
  GTGGTGAGAGAGGCTGATGGCAGTGATGAGCTGAAGCCAGAACAGCAGCACCCTCTCCCTTCCTACCTGG
  AGTACAGGCACAATGCCTCCATTCGGGTGTATCAGACTAATTATTTTGCCAGCAAATGTGCCGAAAATCC
  TAACAGCAACTCCAAGAGTTTTAACATTAAGCTTGGAGCAGAGATGGAGAGCCTAGGTGGAAAATGCGAT
  CCCACTCAGCAAAAATTCTGTGATGGACCACTGAAGCCACACACTGCCTACAGAATCAGCATTCGAGCTT
  TTACACAGCTCTTTGATGAGGACCTGAAGGAATTCACAAAGCCACTCTATTCAGACACATTTTTTTCTTT
  ACCCATCACTACTGAATCAGAGCCCTTGTTTGGAGCTATTGAAGGTGTGAGTGCTGGTCTGTTTTTAATT
  GGCATGCTAGTGGCTGTTGTTGCCTTATTGATCTGCAGACAGAAAGTGAGCCATGGTCGAGAAAGACCCT
  CTGCCCGTCTGAGCATTCGTAGGGATCGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGGTAACCG
  GAAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTACAGGCTGACTCCAAC
  TACCTTCTATCCAAGGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCACTCT
  TGCCGGAGAATAGAGGGAAAAATCGATACAACAATATATTGCCCTATGATGCCACGCGAGTGAAGCTCTC
  CAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGCTACATCCCTGGCAACAACTTCAGAAGA
  GAATACATTGTCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAATGGTGTGGGAACAAA
  ACGTTCACAACATCGTCATGGTGACCCAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGACCATTACTGGCC
  AGCGGACCAGGATTCCCTCTACTATGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAG
  TGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGATGCACACAGACTCATCCGCCACTTTC
  ACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAGTTTGTGAGAACTGT
  CAGGGACTACATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTGCACTGCAGTGCTGGTGTGGGTAGG
  ACTGGAACCTTTATTGCATTGGACCGAATCCTCCAGCAGTTAGACTCCAAAGACTCTGTGGACATTTATG
  GAGCAGTGCACGACCTAAGACTTCACAGGGTTCACATGGTCCAGACTGAGTGTCAGTATGTCTACCTACA
  TCAGTGTGTAAGAGATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAACCCCTTGTTTCCAATC
  TATGAAAATGTGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCATTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001206972
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001206972.1, NP_001193901.1
• RefSeq Size: 10393 bp
• RefSeq ORF: 5724 bp
• Locus ID: 5787
• Cytogenetics: 12q15
• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: Adherens junction
• Gene Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]'
  Transcript Variant: This variant (4) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (d) is shorter and has a distinct N-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.