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PTPRB (NM_001206972) Human Tagged ORF Clone
CAT#: RG235348
- TrueORF®
PTPRB (GFP-tagged) - Homo sapiens protein tyrosine phosphatase, receptor type, B (PTPRB), transcript variant 4
"NM_001206972" in other vectors (2)
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Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | TurboGFP |
| Symbol | PTPRB |
| Synonyms | HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RG235348 representing NM_001206972
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCTGAGCCATGGAGCCGGGTTGGCCTTGTGGATCACACTGAGCCTGCTGCAGACTGGACTGGCGGAGC CAGAGAGATGTAACTTCACCCTGGCGGAGTCCAAGGCCTCCAGCCATTCTGTGTCTATCCAGTGGAGAAT TTTGGGCTCACCCTGTAACTTTAGCCTCATCTATAGCAGTGACACCCTGGGGGCCGCGTTGTGCCCTACC TTTCGGATAGACAACACCACATACGGATGTAACCTTCAAGATTTACAAGCAGGAACCATCTATAACTTCA GGATTATTTCTCTGGATGAAGAGAGAACAGTGGTCTTGCAAACAGATCCTTTACCTCCTGCTAGGTTTGG AGTCAGTAAAGAGAAGACGACTTCAACCAGCTTGCATGTTTGGTGGACTCCTTCTTCCGGAAAAGTCACC TCATATGAGGTGCAATTATTTGATGAAAATAACCAAAAGATACAGGGGGTTCAAATTCAAGAAAGTACTT CATGGAATGAATACACTTTTTTCAATCTCACTGCTGGTAGTAAATACAATATTGCCATCACAGCTGTTTC TGGAGGAAAACGTTCTTTTTCAGTTTATACCAATGGATCAACAGTGCCATCTCCAGTGAAAGATATTGGT ATTTCCACAAAAGCCAATTCTCTCCTGATTTCCTGGTCCCATGGTTCTGGGAATGTGGAACGATACCGGC TGATGCTAATGGATAAAGGGATCCTAGTTCATGGCGGTGTTGTGGACAAACATGCTACTTCCTATGCTTT TCACGGGCTGACCCCTGGCTACCTCTACAACCTCACTGTTATGACTGAGGCTGCAGGGCTGCAAAACTAC AGGTGGAAACTAGTCAGGACAGCCCCCATGGAAGTCTCAAATCTGAAGGTGACAAATGATGGCAGTTTGA CCTCTCTAAAAGTCAAATGGCAAAGACCTCCTGGAAATGTGGATTCTTACAATATCACCCTGTCTCACAA AGGGACCATCAAGGAATCCAGAGTATTAGCACCTTGGATTACTGAAACTCACTTTAAAGAGTTAGTCCCC GGTCGACTTTATCAAGTTACTGTCAGCTGTGTCTCTGGTGAACTGTCTGCTCAGAAGATGGCAGTGGGCA GAACATTTCCAGACAAAGTTGCAAACCTGGAGGCAAACAATAATGGCAGGATGAGGTCTCTTGTAGTGAG CTGGTCGCCCCCTGCTGGAGACTGGGAGCAGTATCGGATCCTACTCTTCAATGATTCTGTGGTGCTGCTC AACATCACTGTGGGAAAGGAAGAAACACAGTATGTCATGGATGACACGGGGCTCGTACCGGGAAGACAGT ATGAGGTGGAAGTCATTGTTGAGAGTGGAAATTTGAAGAATTCTGAGCGTTGCCAAGGCAGGACAGTCCC CCTGGCTGTCCTCCAGCTTCGTGTCAAACATGCCAATGAAACCTCACTGAGTATCATGTGGCAGACCCCT GTAGCAGAATGGGAGAAATACATCATTTCCCTAGCTGACAGAGACCTCTTACTGATCCACAAGTCACTCT CCAAAGATGCCAAAGAATTCACTTTTACTGACCTGGTGCCTGGACGAAAATACATGGCTACAGTCACCAG TATTAGTGGAGACTTAAAAAATTCCTCTTCAGTAAAAGGAAGAACAGTGCCTGCCCAAGTGACTGACTTG CATGTGGCCAACCAAGGAATGACCAGTAGTCTGTTTACTAACTGGACCCAGGCACAAGGAGACGTAGAAT TTTACCAAGTCTTACTGATCCATGAAAATGTGGTCATTAAAAATGAAAGCATCTCCAGTGAGACCAGCAG ATACAGCTTCCACTCTCTCAAGTCCGGCAGCCTGTACTCCGTGGTGGTAACAACAGTGAGTGGAGGGATC TCTTCCCGACAAGTGGTTGTGGAGGGAAGAACAGTCCCTTCCAGTGTGAGTGGAGTAACGGTGAACAATT CCGGTCGTAATGACTACCTCAGCGTTTCCTGGCTGCTGGCGCCCGGAGATGTGGATAACTATGAGGTAAC ATTGTCTCATGACGGCAAGGTGGTTCAGTCCCTTGTCATTGCCAAGTCTGTCAGAGAATGTTCCTTCAGC TCCCTCACCCCAGGCCGCCTCTACACCGTGACCATAACTACAAGGAGTGGCAAGTATGAAAATCACTCCT TCAGCCAAGAGCGGACAGTGCCTGACAAAGTCCAGGGAGTCAGTGTTAGCAACTCAGCCAGGAGTGACTA TTTAAGGGTATCCTGGGTGCATGCCACTGGAGACTTTGATCACTATGAAGTCACCATTAAAAACAAAAAC AACTTCATTCAAACTAAAAGCATTCCCAAGTCAGAAAACGAATGTGTATTTGTTCAGCTAGTCCCTGGAC GGTTGTACAGTGTCACTGTTACTACAAAAAGTGGACAATATGAAGCCAATGAACAAGGGAATGGGAGAAC AATTCCAGAGCCTGTTAAGGATCTAACATTGCGCAACAGGAGCACTGAGGACTTGCATGTGACTTGGTCA GGAGCTAATGGGGATGTCGACCAATATGAGATCCAGCTGCTCTTCAATGACATGAAAGTATTTCCTCCTT TTCACCTTGTAAATACCGCAACCGAGTATCGATTTACTTCCCTAACACCAGGCCGCCAATACAAAATTCT TGTCTTGACGATTAGCGGGGATGTACAGCAGTCAGCCTTCATTGAGGGCTTCACAGTTCCTAGTGCTGTC AAAAATATTCACATTTCTCCCAATGGAGCAACAGATAGCCTGACGGTGAACTGGACTCCTGGTGGGGGAG ACGTTGATTCCTACACGGTGTCGGCATTCAGGCACAGTCAAAAGGTTGACTCTCAGACTATTCCCAAGCA CGTCTTTGAGCACACGTTCCACAGACTGGAGGCCGGGGAGCAGTACCAGATCATGATTGCCTCAGTCAGC GGGTCCCTGAAGAATCAGATAAATGTGGTTGGGCGGACAGTCCCAGCAGCTGTCACCGACCTGAGGATCA CAGAGAACTCCACCAGGCACCTGTCCTTCCGCTGGACCGCCTCAGAGGGGGAGCTCAGCTGGTACAACAT CTTTTTGTACAACCCAGATGGGAATCTCCAGGAGAGAGCTCAAGTTGACCCACTAGTCCAGAGCTTCTCT TTCCAGAACTTGCTACAAGGCAGAATGTACAAGATGGTGATTGTAACTCACAGTGGGGAGCTGTCTAATG AGTCTTTCATATTTGGTAGAACAGTCCCAGCCTCTGTGAGTCATCTCAGGGGGTCCAATCGGAACACGAC AGACAGCCTTTGGTTCAACTGGAGTCCAGCCTCTGGGGACTTTGACTTTTATGAGCTGATTCTCTATAAT CCCAATGGCACAAAGAAGGAAAACTGGAAAGACAAGGACCTGACGGAGTGGCGGTTTCAAGGCCTTGTTC CTGGAAGGAAGTACGTGCTGTGGGTGGTAACTCACAGTGGAGATCTCAGCAATAAAGTCACAGCGGAGAG CAGAACAGCTCCAAGTCCTCCCAGTCTTATGTCATTTGCTGACATTGCAAACACATCCTTGGCCATCACG TGGAAAGGGCCCCCAGACTGGACAGACTACAACGACTTTGAGCTGCAGTGGTTGCCCAGAGATGCACTTA CTGTCTTCAACCCCTACAACAACAGAAAATCAGAAGGACGCATTGTGTATGGTCTTCGTCCAGGGAGATC CTATCAATTCAACGTCAAGACTGTCAGTGGTGATTCCTGGAAAACTTACAGCAAACCAATTTTTGGATCT GTGAGGACAAAGCCTGACAAGATACAAAACCTGCATTGCCGGCCTCAGAACTCCACGGCCATTGCCTGTT CTTGGATCCCTCCTGATTCTGACTTTGATGGTTATAGTATTGAATGCCGGAAAATGGACACCCAAGAAGT TGAGTTTTCCAGAAAGCTGGAGAAAGAAAAATCTCTGCTCAACATCATGATGCTAGTGCCCCATAAGAGG TACCTGGTGTCCATCAAAGTGCAGTCGGCCGGCATGACCAGCGAGGTGGTTGAAGACAGCACTATCACAA TGATAGACCGCCCCCCTCCTCCACCCCCACACATTCGTGTGAATGAAAAGGATGTGCTAATTAGCAAGTC TTCCATCAACTTTACTGTCAACTGCAGCTGGTTCAGCGACACCAATGGAGCTGTGAAATACTTCACAGTG GTGGTGAGAGAGGCTGATGGCAGTGATGAGCTGAAGCCAGAACAGCAGCACCCTCTCCCTTCCTACCTGG AGTACAGGCACAATGCCTCCATTCGGGTGTATCAGACTAATTATTTTGCCAGCAAATGTGCCGAAAATCC TAACAGCAACTCCAAGAGTTTTAACATTAAGCTTGGAGCAGAGATGGAGAGCCTAGGTGGAAAATGCGAT CCCACTCAGCAAAAATTCTGTGATGGACCACTGAAGCCACACACTGCCTACAGAATCAGCATTCGAGCTT TTACACAGCTCTTTGATGAGGACCTGAAGGAATTCACAAAGCCACTCTATTCAGACACATTTTTTTCTTT ACCCATCACTACTGAATCAGAGCCCTTGTTTGGAGCTATTGAAGGTGTGAGTGCTGGTCTGTTTTTAATT GGCATGCTAGTGGCTGTTGTTGCCTTATTGATCTGCAGACAGAAAGTGAGCCATGGTCGAGAAAGACCCT CTGCCCGTCTGAGCATTCGTAGGGATCGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGGTAACCG GAAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTACAGGCTGACTCCAAC TACCTTCTATCCAAGGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCACTCT TGCCGGAGAATAGAGGGAAAAATCGATACAACAATATATTGCCCTATGATGCCACGCGAGTGAAGCTCTC CAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGCTACATCCCTGGCAACAACTTCAGAAGA GAATACATTGTCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAATGGTGTGGGAACAAA ACGTTCACAACATCGTCATGGTGACCCAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGACCATTACTGGCC AGCGGACCAGGATTCCCTCTACTATGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAG TGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGATGCACACAGACTCATCCGCCACTTTC ACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAGTTTGTGAGAACTGT CAGGGACTACATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTGCACTGCAGTGCTGGTGTGGGTAGG ACTGGAACCTTTATTGCATTGGACCGAATCCTCCAGCAGTTAGACTCCAAAGACTCTGTGGACATTTATG GAGCAGTGCACGACCTAAGACTTCACAGGGTTCACATGGTCCAGACTGAGTGTCAGTATGTCTACCTACA TCAGTGTGTAAGAGATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAACCCCTTGTTTCCAATC TATGAAAATGTGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCAT ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >RG235348 representing NM_001206972
Red=Cloning site Green=Tags(s) MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPT FRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVT SYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIG ISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNY RWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVP GRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLL NITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTP VAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDL HVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI SSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFS SLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKN NFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWS GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAV KNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVS GSLKNQINVVGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFS FQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYN PNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAIT WKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPIFGS VRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKR YLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTV VVREADGSDELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCD PTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLI GMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSN YLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRR EYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPE WTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGR TGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPI YENVNPEYHRDPVYSRH TRTRPLE - GFP Tag - V |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001206972 |
| ORF Size | 5721 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers. |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001206972.1, NP_001193901.1 |
| RefSeq Size | 10393 bp |
| RefSeq ORF | 5724 bp |
| Locus ID | 5787 |
| Cytogenetics | 12q15 |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | Adherens junction |
| Gene Summary | 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]' |
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