CLCN3 (NM_001243374) Human Untagged Clone

CAT#: SC331996

CLCN3 (untagged) - Homo sapiens chloride channel, voltage-sensitive 3 (CLCN3), transcript variant c

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CLCN3
• Synonyms: ClC-3; CLC3
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001243374, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGATGCTTCTTCCGACCCTTATTTGCCTTATGACGGGGGAGGAGACAATATTCCCCTGAGGGAATTAC
  ATAAAAGAGGAACTCATTATACAATGACAAATGGAGGCAGCATTAACAGTTCTACACATTTACTGGATCT
  TTTGGATGAACCAATTCCAGGTGTTGGTACATATGATGATTTCCATACTATTGATTGGGTGCGAGAAAAA
  TGTAAAGACAGAGAAAGGCATAGACGGATCAACAGCAAAAAGAAAGAATCAGCATGGGAAATGACAAAAA
  GTTTGTATGATGCGTGGTCAGGATGGCTAGTAGTAACACTAACAGGATTGGCATCAGGGGCACTGGCCGG
  ATTAATAGACATTGCTGCCGATTGGATGACTGACCTAAAGGAGGGCATTTGCCTTAGTGCGTTGTGGTAC
  AACCACGAACAGTGCTGTTGGGGATCTAATGAAACAACATTTGAAGAGAGGGATAAATGTCCACAGTGGA
  AAACATGGGCAGAATTAATCATAGGTCAAGCAGAGGGTCCTGGTTCTTATATCATGAACTACATAATGTA
  CATCTTCTGGGCCTTGAGTTTTGCCTTTCTTGCAGTTTCCCTGGTAAAGGTATTTGCTCCATATGCCTGT
  GGCTCTGGAATTCCAGAGATTAAAACTATTTTAAGTGGATTCATCATCAGAGGTTACTTGGGAAAATGGA
  CTTTAATGATTAAAACCATCACATTAGTCCTGGCTGTGGCATCAGGTTTGAGTTTAGGAAAAGAAGGTCC
  CCTGGTACATGTTGCCTGTTGCTGCGGAAATATCTTTTCCTACCTCTTTCCAAAGTATAGCACAAACGAA
  GCTAAAAAAAGGGAGGTGCTATCAGCTGCCTCAGCTGCAGGGGTTTCTGTAGCTTTTGGTGCACCAATTG
  GAGGAGTTCTTTTTAGCCTGGAAGAGGTTAGCTATTATTTTCCTCTCAAAACTTTATGGAGATCATTTTT
  TGCTGCTTTAGTGGCTGCATTTGTTTTGAGGTCCATCAATCCATTTGGTAACAGCCGTCTGGTCCTTTTT
  TATGTGGAGTATCATACACCATGGTACCTTTTTGAACTGTTTCCTTTTATTCTTCTAGGGGTATTTGGAG
  GGCTTTGGGGAGCCTTTTTCATTAGGGCAAATATTGCCTGGTGTCGTCGACGCAAGTCCACGAAATTTGG
  AAAGTATCCCGTTCTGGAAGTCATTATTGTTGCAGCCATTACTGCTGTGATAGCCTTCCCTAATCCATAC
  ACTAGGCTAAACACCAGTGAACTGATCAAAGAGCTTTTTACAGACTGTGGTCCCCTGGAATCCTCTTCTC
  TTTGTGACTACAGAAATGACATGAATGCCAGTAAAATTGTCGATGACATTCCTGATCGTCCAGCAGGCAT
  TGGAGTATATTCAGCTATATGGCAGTTATGCCTGGCACTCATATTTAAAATCATAATGACAGTATTCACT
  TTTGGCATCAAGGTTCCATCAGGCTTGTTCATCCCCAGCATGGCCATTGGAGCGATCGCAGGAAGGATTG
  TGGGGATTGCGGTGGAGCAGCTTGCCTACTATCACCACGACTGGTTTATCTTTAAGGAGTGGTGTGAGGT
  CGGGGCTGATTGCATTACACCTGGCCTTTATGCCATGGTTGGTGCTGCTGCATGCTTAGGTGGTGTGACA
  AGAATGACTGTCTCCCTGGTGGTTATTGTTTTTGAGCTTACTGGAGGCTTGGAATATATTGTTCCCCTTA
  TGGCTGCAGTCATGACCAGTAAATGGGTTGGAGATGCCTTTGGCAGGGAAGGCATTTATGAAGCACACAT
  CCGATTAAATGGATACCCTTTCTTGGATGCAAAAGAAGAATTCACTCATACCACCCTGGCTGCTGACGTT
  ATGAGACCTCGAAGGAATGATCCTCCCTTAGCTGTCCTGACACAGGACAATATGACAGTGGATGATATAG
  AAAACATGATTAATGAAACCAGCTACAATGGATTTCCTGTCATAATGTCAAAAGAATCTCAGAGATTAGT
  GGGATTTGCCCTCAGAAGAGACCTGACAATTGCAATAGAAAGTGCCAGGAAAAAACAAGAAGGTATCGTT
  GGCAGTTCTCGGGTGTGTTTTGCACAGCACACCCCATCTCTTCCAGCAGAAAGTCCTCGGCCATTGAAGC
  TTCGAAGCATTCTTGACATGAGCCCTTTTACAGTGACAGACCACACCCCAATGGAGATCGTGGTGGATAT
  TTTCCGAAAGCTGGGACTGAGGCAGTGCCTTGTAACTCACAATGGGCGCCTCCTTGGCATTATAACAAAA
  AAAGATATCCTCCGGCATATGGCCCAGACGGCAAACCAAGACCCCGCTTCAATAATGTTCAACTGA
  
  
• Restriction Sites: AscI-MluI
• ACCN: NM_001243374
• ORF Size: 2376 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001243374.1, NP_001230303.1
• RefSeq Size: 5891
• RefSeq ORF: 2376
• Locus ID: 1182
• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Gene Summary: This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
  Transcript Variant: This variant (c) lacks two exons from the 5' end but has an alternate 5' exon, compared to variant b. The resulting isoform (c) has a shorter and distinct N-terminus, compared to isoform b. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.