DIP13B (APPL2) (NM_001251904) Human Untagged Clone

CAT#: SC332146

APPL2 (untagged) - Homo sapiens adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (APPL2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: APPL2
• Synonyms: DIP13B
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001251904, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCCCGCCGTGGACAAGCTCCTGCTAGAGGAGGCGTTGCAGGACAGCCCCCAGACTCGCTCTTTACTGA
  GCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATACCAACCAGCTGCTCCAGGCAATGCAGCGCGT
  CTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATATGAAAAA
  CAGAACTTTGCTCTTGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGG
  ATGAGCTTAATCTTCTCCATACAGAGCTGGCTAAACAGTTGGCAGACACAATGGTTCTACCTATCATACA
  ATTCCGAGAAAAGGATCTCACAGAAGTAAGCACTTTAAAGGATCTATTTGGACTCGCTAGCAATGATGTC
  TGTTTATTTTTAGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGA
  AGGTGAAGACCGAAGTCGGAAAAGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGTA
  CTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGCCATGATGGAGCCCATGATAGGCTTTGCC
  CATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTTTTTATCCT
  CCGTTGCAGACATGGTTCAAAGCATTCAGGTAGAACTGGAAGCCGAGGCGGAAAAGATGCGGGTGTCCCA
  GCAAGAATTACTTTCTGTTGATGAATCTGTTTACACTCCAGACTCTGATGTGGCCGCACCACAGATCAAC
  AGGAACCTCATCCAGAAGGCTGGTTACCTTAATCTTAGAAACAAAACAGGGCTGGTCACCACCACCTGGG
  AGAGGCTTTATTTCTTCACCCAAGGCGGGAATCTCATGTGTCAGCCCAGGGGAGCCGTGGCTGGAGGTTT
  GATCCAGGACCTGGACAACTGCTCAGTGATGGCCGTGGATTGCGAAGACCGGCGCTACTGCTTCCAGATC
  ACCACGCCCAATGGAAAATCGGGAATAATCCTCCAGGCTGAGAGCAGAAAGGAAAATGAAGAGTGGATAT
  GTGCAATAAACAACATCTCCAGACAGATCTACCTGACCGACAACCCTGAGGCAGTCGCGATCAAGTTGAA
  TCAGACCGCTCTGCAAGCAGTGACTCCCATTACAAGTTTTGGAAAAAAACAAGAAAGCTCATGCCCCAGC
  CAGAACCTGAAAAATTCAGAGATGGAAAATGAAAATGACAAGATTGTTCCCAAAGCAACAGCCAGTCTAC
  CTGAAGCAGAGGAGCTGATCGCGCCTGGAACGCCGATTCAATTCGATATTGTGCTTCCTGCTACAGAATT
  CCTTGATCAGAACAGAGGGAGCAGGCGTACCAACCCTTTTGGTGAAACTGAGGATGAATCATTTCCAGAA
  GCAGAAGATTCTCTTTTGCAGCAGATGTTTATAGTTCGGTTTTTGGGATCAATGGCAGTTAAAACAGACA
  GCACTACTGAAGTGATTTATGAAGCGATGAGACAAGTATTGGCTGCTCGGGCTATTCATAACATCTTCCG
  CATGACAGAATCCCATCTGATGGTCACCAGTCAATCTTTGAGGTTGATAGATCCACAGACTCAAGTATCA
  AGGGCCAATTTTGAACTTACCAGTGTCACACAATTTGCTGCTCATCAAGAAAACAAGAGACTGGTTGGTT
  TTGTCATCCGTGTTCCTGAATCCACTGGAGAAGAATCTCTGAGTACATACATTTTTGAAAGCAACTCAGA
  AGGCGAAAAGATATGTTATGCTATTAATTTGGGAAAAGAAATTATTGAGGTTCAGAAGGATCCAGAAGCA
  CTGGCTCAATTAATGCTGTCCATACCACTAACCAATGACGGAAAATATGTACTGTTAAACGATCAACCAG
  ATGACGATGATGGAAATCCAAACGAACATAGAGGCGCAGAATCCGAAGCATAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001251904
• ORF Size: 2013 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001251904.1, NP_001238833.1
• RefSeq Size: 3307
• RefSeq ORF: 2013
• Locus ID: 55198
• Gene Summary: The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
  Transcript Variant: This variant (2) has an additional in-frame segment in the coding region, compared to variant 1. The resulting isoform 2 is longer than isoform 1.