FBXL11 (KDM2A) (NM_001256405) Human Untagged Clone

CAT#: SC332373

KDM2A (untagged) - Homo sapiens lysine (K)-specific demethylase 2A (KDM2A), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KDM2A
• Synonyms: CXXC8; FBL7; FBL11; FBXL11; JHDM1A; LILINA
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001256405, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGTGCTCTGGGAGATTCCAGAATATTCAAGTAAATCCGGATTTTCCCAGAGGCAGAATATCTAACTCCT
  TCAGGAGAACTTCCAGTACAGAAAACAAAACAAAGACGCTGGGGAAACTTCACCAAGAGCCTCGGCAGCT
  CCAGAGCGACGGGAAACGAAAGATTTTGCTGGAGGAGCTTGCCAACAGCGATCCCAAGTTAGCCCTCACT
  GGAGTTCCTATAGTACAGTGGCCAAAAAGGGATAAGCTTAAATTCCCCACTCGGCCAAAGGTGCGGGTTC
  CTACCATCCCCATTACGAAGCCTCACACTATGAAACCAGCTCCACGGTTAACACCTGTGAGGCCAGCTGC
  TGCCTCCCCGATTGTGTCAGGAGCCAGACGGAGACGAGTGCGATGTCGAAAATGCAAAGCCTGTGTGCAA
  GGAGAGTGTGGTGTTTGCCACTACTGCAGAGACATGAAGAAGTTTGGGGGGCCTGGACGCATGAAGCAGT
  CCTGTGTCCTCCGACAGTGCTTGGCACCCAGACTGCCTCACTCAGTCACATGTTCCCTCTGTGGAGAGGT
  GGATCAGAATGAAGAGACACAAGACTTTGAGAAGAAACTCATGGAATGCTGTATCTGCAATGAGATTGTT
  CATCCTGGCTGCCTCCAGATGGACGGAGAGGGGTTGCTTAACGAAGAATTGCCAAATTGCTGGGAATGTC
  CAAAGTGCTACCAGGAGGACAGCTCGGAGAAAGCCCAGAAGCGGAAAATGGAAGAGAGTGACGAAGAAGC
  TGTGCAAGCCAAAGTCCTGCGGCCCCTGCGGAGCTGCGATGAGCCTCTCACGCCCCCGCCTCATTCACCC
  ACTTCCATGCTGCAGCTCATCCATGACCCGGTTTCCCCCCGGGGTATGGTGACTCGGTCATCCCCTGGGG
  CTGGCCCCAGCGACCACCACAGTGCCAGCCGCGATGAGCGCTTCAAACGGCGGCAGTTGCTGCGGCTGCA
  GGCCACAGAGCGCACCATGGTACGGGAAAAGGAGAACAATCCCAGCGGCAAAAAGGAGCTGTCTGAAGTT
  GAGAAAGCCAAGATCCGGGGATCGTACCTCACTGTCACGCTACAGAGGCCCACCAAAGAGCTCCACGGGA
  CATCCATTGTGCCCAAGCTGCAGGCCATCACGGCCTCCTCTGCCAACCTTCGCCATTCCCCCCGTGTGCT
  AGTGCAGCACTGCCCAGCCCGAACCCCCCAGCGTGGGGATGAGGAGGGGCTGGGGGGAGAGGAGGAGGAA
  GAGGAGGAGGAGGAGGAGGAAGATGACAGTGCAGAGGAGGGGGGTGCAGCCAGGCTGAATGGCCGGGGCA
  GTTGGGCTCAGGATGGAGACGAAAGCTGGATGCAGCGGGAGGTCTGGATGTCTGTCTTCCGCTACCTCAG
  CCGCAGAGAACTTTGTGAATGTATGCGAGTGTGCAAGACGTGGTATAAATGGTGCTGCGACAAGAGACTT
  TGGACAAAAATTGACTTGAGTAGGTGTAAGGCCATTGTGCCCCAGGCCCTCAGTGGCATCATCAAGAGGC
  AGCCAGTCAGCCTTGACCTCAGTTGGACCAACATCTCTAAAAAGCAACTGACATGGCTCGTCAATAGGCT
  GCCAGGACTGAAAGACCTCCTCCTAGCAGGCTGCTCCTGGTCTGCAGTCTCTGCCCTCAGCACCTCCAGC
  TGCCCCCTTCTCAGGACCCTTGATCTTCGGTGGGCAGTAGGAATCAAGGACCCTCAAATTCGGGACTTGC
  TTACTCCACCGGCTGATAAACCAGGTCAGGACAATCGCAGCAAGCTCCGGAACATGACCGACTTCCGGCT
  GGCAGGCCTTGACATCACAGATGCCACGCTTCGCCTCATAATTCGCCACATGCCCCTCCTGTCTCGACTC
  GACCTCAGTCACTGCAGCCACCTTACAGATCAGTCCTCCAATCTACTCACTGCTGTCGGGTCTTCCACTC
  GCTACTCTCTCACAGAGCTCAATATGGCAGGTTGCAATAAATTGACAGACCAGACCCTGATCTACCTACG
  GCGCATTGCCAACGTCACCTTGATCGACCTTCGAGGATGCAAGCAGATCACTCGAAAAGCCTGCGAGCAC
  TTCATCTCAGACTTGTCCATCAACAGCCTCTACTGCCTGTCTGACGAGAAGCTGATACAGAAGATCAGCT
  AA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001256405
• ORF Size: 2172 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_001256405.1, NP_001243334.1
• RefSeq Size: 5379
• RefSeq ORF: 2172
• Locus ID: 22992
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
  Transcript Variant: This variant (3) lacks several 5' exons but contains an alternate 5' exon, uses an internal downstream promoter, and differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b, also known as SF-KDM2A or short-form KDM2A) has a distinct and shorter N-terminus, compared to isoform a.