BLNK (NM_001258440) Human Untagged Clone

CAT#: SC332710

BLNK (untagged) - Homo sapiens B-cell linker (BLNK), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BLNK
• Synonyms: AGM4; BASH; bca; BLNK-S; LY57; SLP-65; SLP65
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001258440, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCAGAAGTTGAGGCAGCTTCAAAAGATGGTCCATG
  ATATTAAAAACAATGAAGGTGGAATAATGAATAAAATCAAAAAGCTAAAAGTCAAAGCACCTCCAAGTGT
  TCCTCGAAGGGACTACGCTTCAGAGAGCCCTGCTGACGAAGAGGAGCAGTGGTCCGATGACTTTGACAGC
  GACTATGAAAATCCAGATGAGCACTCGGACTCAGAGATGTACGTGATGCCCGCCGAGGAGAACGCTGATG
  ACAGCTACGAGCCGCCTCCAGTAGAGCAGGAAACCAGGCCGGTTCACCCAGCCCTGCCCTTCGCCAGAGG
  CGAGTATATAGACAATCGATCAAGCCAGAGGCATTCCCCACCCTTCAGCAAGACACTTCCCAGTAAGCCC
  AGCTGGCCTTCAGAGAAAGCAAGGCTCACCTCCACCCTGCCGGCCCTGACTGCTTTGCAGAAACCTCAAG
  TCCCACCCAAACCCAAAGGCCTCCTTGAGGATGAGGCTGATTATGTGGTCCCCGTGGAAGATAATGATGA
  AAACTATATTCATCCCACAGAAAGCAGTTCACCTCCACCTGAAAAAGCTCCCATGGTGAATAGATCAACC
  AAGCCAAATTCCTCAACGCCCGCCTCTCCTCCAGGAACAGCTTCAGGTCGAAACAGTGGGGCCTGGGAAA
  CCAAGTCACCTCCACCAGCTGCACCATCCCCGTTGCCACGGGCCGGGAAAAAACCAACGACACCACTGAA
  GACAACTCCAGTTGCCTCTCAACAGAATGCTTCAAGTGTTTGTGAAGAAAAACCTATACCTGCTGAACGC
  CACCGAGGGTCAAGTCACAGACAAGAAGCTGTGCAGTCACCAGTGTTTCCTCCTGCCCAGAAACAAATCC
  ACCAAAAACCCATACCTCTGCCAAGATTTACAGAAGGGGGAAACCCAACTGTGGATGGGCCCCTACCCAG
  CTTTTCATCTAATTCCACTATTTCAGAACAGGAAGCTGGCGTTCTCTGCAAGCCATGGTATGCTGGAGCC
  TGTGATCGAAAGTCTGCTGAAGAGGCATTGCACAGATCAAACAAGTACTTTGGAAGTGTTGCTGAAATCA
  TCAGGAATCATCAACATAGTCCTTTGGTTCTTATTGACAGTCAGAATAACACAAAAGATTCCACCAGACT
  GAAGTATGCAGTTAAAGTTTCATAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001258440
• ORF Size: 1215 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001258440.1, NP_001245369.1
• RefSeq Size: 1613
• RefSeq ORF: 1215
• Locus ID: 29760
• Protein Families: Druggable Genome
• Protein Pathways: B cell receptor signaling pathway, Primary immunodeficiency
• Gene Summary: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
  Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region compared to variant 1, resulting in a shorter isoform (3) compared to isoform 1.