TOP1MT (NM_001258447) Human Untagged Clone

CAT#: SC332714

TOP1MT (untagged) - Homo sapiens topoisomerase (DNA) I, mitochondrial (TOP1MT), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TOP1MT
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001258447, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGTTAGATCATGAATACACAACAAAGGAGGTTTTCCGGAAGAACTTCTTCAATGACTGGCGAAAGGAAA
  TGGCGGTGGAAGAGAGGGAAGTCATCAAGAGCCTGGACAAGTGTGACTTCACGGAGATCCACAGATACTT
  TGTGGACAAGGCCGCAGCCCGGAAAGTCCTGAGCAGGGAGGAGAAGCAGAAGCTAAAAGAAGAGGCAGAA
  AAACTTCAGCAAGAGTTCGGCTACTGTATTTTAGATGGTCACCAAGAAAAAATAGGCAACTTCAAGATTG
  AGCCGCCTGGCTTGTTCCGTGGCCGTGGCGACCATCCCAAGATGGGGATGCTGAAGAGAAGGATCACGCC
  AGAGGATGTGGTTATCAACTGCAGCAGGGACTCGAAGATCCCCGAGCCGCCGGCGGGGCACCAGTGGAAG
  GAGGTGCGCTCCGATAACACCGTCACGTGGCTGGCAGCTTGGACCGAGAGCGTTCAGAACTCCATCAAGT
  ACATCATGCTGAACCCTTGCTCGAAGCTGAAGGGGGAGACAGCTTGGCAGAAGTTTGAAACAGCTCGACG
  CCTGCGGGGATTTGTGGACGAGATCCGCTCCCAGTACCGGGCTGACTGGAAGTCTCGGGAAATGAAGACG
  AGACAGCGGGCGGTGGCCCTGTATTTCATCGATAAGCTGGCACTGAGAGCAGGAAATGAGAAGGAGGACG
  GTGAGGCGGCCGACACCGTGGGCTGCTGTTCCCTCCGCGTGGAGCACGTCCAGCTGCACCCGGAGGCCGA
  TGGCTGCCAACACGTGGTGGAATTTGACTTCCTGGGGAAGGACTGCATCCGCTACTACAACAGAGTGCCG
  GTGGAGAAGCCGGTGTACAAGAACTTACAGCTCTTTATGGAGAACAAGGACCCCCGGGACGACCTCTTCG
  ACAGGCTGACCACGACCAGCCTGAACAAGCACCTCCAGGAGCTGATGGACGGGCTGACGGCCAAGGTGTT
  CCGGACCTACAACGCCTCCATCACTCTGCAGGAGCAGCTGCGGGCCCTGACGCGCGCCGAGGACAGCATA
  GCAGCTAAGATCTTATCCTACAACCGAGCCAACCGAGTCGTGGCCATTCTCTGCAACCATCAGCGAGCAA
  CCCCCAGTACGTTCGAGAAGTCGATGCAGAATCTCCAGACGAAGATCCAGGCAAAGAAGGAGCAGGTGGC
  TGAGGCCAGGGCAGAGCTGAGGAGGGCGAGGGCTGAGCACAAAGCCCAAGGGGATGGCAAGTCCAGGAGT
  GTCCTGGAGAAGAAGAGGCGGCTCCTGGAGAAGCTGCAGGAGCAGCTGGCGCAGCTGAGTGTGCAGGCCA
  CGGACAAGGAGGAGAACAAGCAGGTGGCCCTGGGCACGTCCAAGCTCAACTACCTGGACCCCAGGATCAG
  CATTGCCTGGTGCAAGCGGTTCAGGGTGCCAGTGGAGAAGATCTACAGCAAAACACAGCGGGAGAGGTTC
  GCCTGGGCTCTCGCCATGGCAGGAGAAGACTTTGAATTCTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001258447
• ORF Size: 1512 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001258447.1, NP_001245376.1
• RefSeq Size: 1904
• RefSeq ORF: 1512
• Locus ID: 116447
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
  Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.