SHANK3 (NM_033517) Human Untagged Clone

CAT#: SC333299

SHANK3 (untagged) - Homo sapiens SH3 and multiple ankyrin repeat domains 3 (SHANK3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SHANK3
• Synonyms: DEL22q13.3; PROSAP2; PSAP2; SCZD15; SPANK-2
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_033517, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCC
  TGCGCCTGGACCCGGCCGCGCCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCT
  CCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCCCGGGGCCGCGCCGGCAAGTTCCTGGATGAG
  GAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTTCGATACAAGC
  GGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGGCGAACCTGAA
  GAAGTTCATGGACTACGTCCAGCTGCATAGCACGGACAAGGTGGCACGCCTGTTGGACAAGGGGCTGGAC
  CCCAACTTCCATGACCCTGACTCAGGAGAGTGCCCCCTGAGCCTCGCAGCCCAGCTGGACAACGCCACGG
  ACCTGCTAAAGGTGCTGAAGAATGGTGGTGCCCACCTGGACTTCCGCACTCGCGATGGGCTCACTGCCGT
  GCACTGTGCCACACGCCAGCGGAATGCGGCAGCACTGACGACCCTGCTGGACCTGGGGGCTTCACCTGAC
  TACAAGGACAGCCGCGGCTTGACACCCCTCTACCACAGCGCCCTGGGGGGTGGGGATGCCCTCTGCTGTG
  AGCTGCTTCTCCACGACCACGCTCAGCTGGGGATCACCGACGAGAATGGCTGGCAGGAGATCCACCAGGC
  CTGCCGCTTTGGGCACGTGCAGCATCTGGAGCACCTGCTGTTCTATGGGGCAGACATGGGGGCCCAGAAC
  GCCTCGGGGAACACAGCCCTGCACATCTGTGCCCTCTACAACCAGGAGAGCTGTGCTCGTGTCCTGCTCT
  TCCGTGGAGCTAACAGGGATGTCCGCAACTACAACAGCCAGACAGCCTTCCAGGTGGCCATCATCGCAGG
  GAACTTTGAGCTTGCAGAGGTTATCAAGACCCACAAAGACTCGGATGTTGTACCATTCAGGGAAACCCCC
  AGCTATGCGAAGCGGCGGCGACTGGCTGGCCCCAGTGGCTTGGCATCCCCTCGGCCTCTGCAGCGCTCAG
  CCAGCGATATCAACCTGAAGGGGGAGGCACAGCCAGCAGCTTCTCCTGGACCCTCGCTGAGAAGCCTCCC
  CCACCAGCTGCTGCTCCAGCGGCTGCAAGAGGAGAAAGATCGTGACCGGGATGCCGACCAGGAGAGCAAC
  ATCAGTGGCCCTTTAGCAGGCAGGGCCGGCCAAAGCAAGATCAGCCCGAGCGGGCCCGGCGGCCCCGGCC
  CCGCGCCCGGCCCCGGCCCCGCGCCCCCTGCGCCCCCCGCACCGCCGCCCCGGGGCCCGAAGCGGAAACT
  TTACAGCGCCGTCCCCGGCCGCAAGTTCATCGCCGTGAAGGCGCACAGCCCGCAGGGTGAAGGCGAGATC
  CCGCTGCACCGCGGCGAGGCCGTGAAGGTGCTCAGCATTGGGGAGGGCGGTTTCTGGGAGGGAACCGTGA
  AAGGCCGCACGGGCTGGTTCCCGGCCGACTGCGTGGAGGAAGTGCAGATGAGGCAGCATGACACACGGCC
  TGAAACGCGGGAGGACCGGACGAAGCGGCTCTTTCGGCACTACACAGTGGGCTCCTACGACAGCCTCACC
  TCACACAGCGATTATGTCATTGATGACAAAGTGGCTGTCCTGCAGAAACGGGACCACGAGGGCTTTGGTT
  TTGTGCTCCGGGGAGCCAAAGCAGAGACCCCCATCGAGGAGTTCACGCCCACGCCAGCCTTCCCGGCGCT
  GCAGTATCTCGAGTCGGTGGACGTGGAGGGTGTGGCCTGGAGGGCCGGGCTGCGCACGGGAGACTTCCTC
  ATCGAGGTGAACGGGGTGAACGTGGTGAAGGTCGGACACAAGCAGGTGGTGGCTCTGATTCGCCAGGGTG
  GCAACCGCCTCGTCATGAAGGTTGTGTCTGTGACAAGGAAGCCAGAAGAGGACGGGGCTCGGCGCAGAGC
  CCCACCGCCCCCCAAGAGGGCCCCCAGCACCACACTGACCCTGCGCTCCAAGTCCATGACAGCTGAGCTC
  GAGGAACTTGCCTCCATTCGGAGAAGAAAAGGGGAGAAGCTGGACGAGATGCTGGCAGCCGCCGCAGAGC
  CAACGCTGCGGCCAGACATCGCAGACGCAGACTCCAGAGCCGCCACCGTCAAACAGAGGCCCACCAGTCG
  GAGGATCACACCCGCCGAGATTAGCTCATTGTTTGAACGCCAGGGCCTCCCAGGCCCAGAGAAGCTGCCG
  GGCTCCTTGCGGAAGGGGATTCCACGGACCAAGTCTGTAGGGGAGGACGAGAAGCTGGCGTCCCTGCTGG
  AAGGGCGCTTCCCGCGGAGCACCTCGATGCAAGACCCGGTGCGCGAGGGTCGCGGCATCCCGCCCCCGCC
  GCAGACCGCGCCGCCTCCCCCGCCCGCGCCCTACTACTTCGACTCGGGGCCGCCCCCGGCCTTCTCGCCG
  CCGCCCCCGCCGGGCCGCGCCTACGACACGGTGCGCTCCAGCTTCAAGCCCGGCCTGGAGGCGCGCCTGG
  GCGCGGGCGCTGCCGGCCTGTACGAGCCGGGCGCGGCCCTCGGCCCGCTGCCGTATCCCGAGCGGCAGAA
  GCGCGCGCGCTCCATGATCATCCTGCAGGACTCGGCGCCCGAGTCGGGCGACGCCCCTCGACCCCCGCCC
  GCGGCCACCCCGCCCGAGCGACCCAAGCGCCGGCCGCGGCCGCCCGGCCCCGACAGCCCCTACGCCAACC
  TGGGCGCCTTCAGCGCCAGCCTCTTCGCTCCGTCCAAGCCGCAGCGCCGCAAGAGCCCCCTGGTGAAGCA
  GCTGCAGGTGGAGGACGCGCAGGAGCGCGCGGCCCTGGCCGTGGGCAGCCCCGGTCCCGGCGGCGGCAGC
  TTCGCCCGCGAGCCCTCCCCGACCCACCGCGGTCCGCGCCCGGGTGGCCTCGACTACGGCGCGGGCGATG
  GCCCGGGGCTCGCGTTCGGCGGCCCGGGCCCGGCCAAGGACCGGCGGCTGGAGGAGCGGCGCCGCTCCAC
  TGTGTTCCTGTCCGTGGGGGCCATCGAGGGCAGCGCCCCCGGCGCGGATCTGCCATCCCTACAGCCCTCC
  CGCTCCATCGACGAGCGCCTCCTGGGGACCGGCCCCACCGCCGGCCGCGACCTGCTGCTGCCCTCCCCGG
  TGTCTGCCCTGAAGCCGTTGGTCAGCGGCCCGAGCCTGGGGCCCTCGGGTTCCACCTTCATCCACCCACT
  CACCGGCAAACCCCTGGACCCCAGCTCACCCCTGGCCCTTGCCCTGGCTGCCCGAGAGCGAGCTCTGGCC
  TCCCAGGCGCCCTCCCGGTCCCCCACACCCGTGCACAGTCCCGACGCCGACCGCCCCGGACCCCTGTTTG
  TGGATGTACAGGCCCGGGACCCAGAGCGAGGGTCCCTGGCTTCCCCGGCTTTCTCCCCACGGAGCCCAGC
  CTGGATTCCTGTGCCTGCTCGCAGGGAGGCAGAGAAGGTCCCCCGGGAGGAGCGGAAGTCACCCGAGGAC
  AAGAAGTCCATGATCCTCAGCGTCCTGGACACATCCCTGCAGCGGCCAGCTGGCCTCATCGTTGTGCACG
  CCACCAGCAACGGGCAGGAGCCCAGCAGGCTGGGGGGGGCCGAAGAGGAGCGCCCGGGCACCCCGGAGTT
  GGCCCCGGCCCCCATGCAGTCAGCGGCTGTGGCAGAGCCCCTGCCCAGCCCCCGGGCCCAGCCCCCTGGT
  GGCACCCCGGCAGACGCCGGGCCAGGCCAGGGCAGCTCAGAGGAAGAGCCAGAGCTGGTGTTTGCTGTGA
  ACCTGCCACCTGCCCAGCTGTCGTCCAGCGATGAGGAGACCAGGGAGGAGCTGGCCCGAATTGGGTTGGT
  GCCACCCCCTGAAGAGTTTGCCAACGGGGTCCTGCTGGCCACCCCACTCGCTGGCCCGGGCCCCTCGCCC
  ACCACGGTGCCCAGCCCGGCCTCAGGGAAGCCCAGCAGTGAGCCACCCCCTGCCCCTGAGTCTGCAGCCG
  ACTCTGGGGTGGAGGAGGCTGACACACGCAGCTCCAGCGACCCCCACCTGGAGACCACAAGCACCATCTC
  CACGGTGTCCAGCATGTCCACCTTGAGCTCGGAGAGCGGGGAACTCACTGACACCCACACCTCCTTCGCT
  GACGGACACACTTTTCTACTCGAGAAGCCACCAGTGCCTCCCAAGCCCAAGCTCAAGTCCCCGCTGGGGA
  AGGGGCCGGTGACCTTCAGGGACCCGCTGCTGAAGCAGTCCTCGGACAGCGAGCTCATGGCCCAGCAGCA
  CCACGCCGCCTCTGCCGGGCTGGCCTCTGCCGCCGGGCCTGCCCGCCCTCGCTACCTCTTCCAGAGAAGG
  TCCAAGCTATGGGGGGACCCCGTGGAGAGCCGGGGGCTCCCTGGGCCTGAAGACGACAAACCAACTGTGA
  TCAGTGAGCTCAGCTCCCGCCTGCAGCAGCTGAACAAGGACACGCGTTCCCTGGGGGAGGAACCAGTTGG
  TGGCCTGGGCAGCCTGCTGGACCCTGCCAAGAAGTCGCCCATCGCAGCAGCTCGGCTCTTCAGCAGCCTC
  GGTGAGCTGAGCTCCATTTCAGCGCAGCGCAGCCCCGGGGGCCCGGGCGGCGGGGCCTCGTACTCGGTGA
  GGCCCAGTGGCCGCTACCCCGTGGCGAGACGCGCCCCGAGCCCGGTGAAGCCCGCGTCGCTGGAGCGGGT
  GGAGGGGCTGGGGGCGGGCGCGGGGGGCGCAGGGCGGCCCTTCGGCCTCACGCCCCCCACCATCCTCAAG
  TCGTCCAGCCTCTCCATCCCGCACGAGCCCAAGGAGGTGCGCTTCGTGGTGCGCAGCGTGAGCGCGCGCA
  GTCGCTCCCCCTCGCCGTCGCCGCTGCCCTCGCCCGCGTCCGGCCCCGGCCCCGGCGCCCCCGGCCCACG
  CCGACCCTTCCAGCAGAAGCCGCTGCAGCTCTGGAGCAAGTTCGACGTGGGCGACTGGCTGGAGAGCATC
  CACCTAGGCGAGCACCGCGACCGCTTCGAGGACCATGAGATAGAAGGCGCGCACCTACCCGCGCTTACCA
  AGGACGACTTCGTGGAGCTGGGCGTCACGCGCGTGGGCCACCGCATGAACATCGAGCGCGCGCTCAGGCA
  GCTGGACGGCAGCTGA
  
  
• Restriction Sites: SgfI-NheI
• ACCN: NM_033517
• ORF Size: 5196 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_033517.1, NP_277052.1
• RefSeq Size: 7113
• RefSeq ORF: 5196
• Locus ID: 85358
• Gene Summary: This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar 2012]