ITM2C (NM_001287241) Human Untagged Clone
CAT#: SC334938
ITM2C (untagged) - Human integral membrane protein 2C (ITM2C), transcript variant 5
"NM_001287241" in other vectors (1)
Product Images
![](https://cdn.origene.com/img/defaults-img-expression-plasmids.jpg)
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Symbol | ITM2C |
Synonyms | BRI3; BRICD2C; E25; E25C; ITM3 |
Vector | pCMV6-Entry |
Sequence Data |
>SC334938 representing NM_001287241.
Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGTGAAGATTAGCTTCCAGCCCGCCGTGGCTGGCATCAAGGGCGACAAGGCTGACAAGGCGTCGGCG TCGGCCCCTGCGCCGGCCTCGGCCACCGAGATCCTGCTGACGCCGGCTAGGGAGGAGCAGCCCCCACAA CATCGATCCAAGAGGGGGGGCTCAGTGGGCGGCGTGTGCTACCTGTCGATGGGCATGGTCGTGCTGCTC ATGGGCCTCGTGTTCGCCTCTGTCTACATCTACAGATACTTCTTCCTTGCGCAGCTGGCCCGAGATAAC TTCTTCCGCTGTGGTGTGCTGTATGAGGACTCCCTGTCCTCCCAGGTCCGGACTCAGATGGAGCTGGAA GAGGATGTGAAAATCTACCTCGACGAGAACTACGAGCGCATCAACGTGCCTGTGCCCCAGTTTGGCGGC GGTGACCCTGCAGACATCATCCATGACTTCCAGCGGGGTCTGACTGCGTACCATGATATCTCCCTGGAC AAGTGCTATGTCATCGAACTCAACACCACCATTGTGCTGCCCCCTCGCAACTTCTGGGAGCTCCTCATG AACGTGAAGAGGGGGACCTACCTGCCGCAGACGTACATCATCCAGGAGGAGATGGTGGTCACGGAGCAT GTCAGTGACAAGGAGGCCCTGGGGTCCTTCATCTACCACCTGTGCAACGGGAAAGACACCTACCGGCTC CGGCGCCGGGCAACGCGGAGGCGGATCAACAAGCGTGGGGCCAAGAACTGCAATGCCATCCGCCACTTC GAGAACACCTTCGTGGTGGAGACGCTCATCTGCGGGGTGGTGTGA |
Restriction Sites |
SgfI-MluI
Plasmid Map
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ACCN | NM_001287241 |
Insert Size | 804 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001287241.1 |
RefSeq Size | 2247 bp |
RefSeq ORF | 804 bp |
Locus ID | 81618 |
UniProt ID | Q9NQX7 |
Cytogenetics | 2q37.1 |
Protein Families | Transmembrane |
MW | 30.2 kDa |
Gene Summary | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Both variants 1 and 5 encode the same isoform (1). |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC237044 | ITM2C (myc-DDK-tagged) - Human integral membrane protein 2C (ITM2C), transcript variant 5 |
USD 420.00 |
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