LNK (SH2B3) (NM_001291424) Human Untagged Clone

CAT#: SC335709

SH2B3 (untagged) - Human SH2B adaptor protein 3 (SH2B3), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SH2B3
• Synonyms: IDDM20; LNK
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001291424, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGGATTCCCGGTGCTGTGCCGTGGCTGGAGGAGGACCTGGCCTGGCTGTGCCAGTTGGCTGGGAGCCC
  CTCCACCCCAGAAGCCCTTGCTCTCACCTCTTCTTCTGAATCATCGTTCTTCGAAGAGTTCAAGGCCCAA
  GCTACAAGCAGCTTGCTCCAGCATCCAGGAGGTCCGGTGGTGCACACGGCTTGAGATGCCTGACAACCTT
  TACACCTTTGTGCTGAAGGTGAAGGACCGGACAGACATCATCTTTGAGGTGGGAGACGAGCAGCAGCTGA
  ATTCATGGATGGCTGAGCTCTCGGAGTGCACAGGCCGAGGGCTGGAGAGCACAGAAGCAGAGATGCATAT
  TCCCTCAGCCCTAGAGCCTAGCACGTCCAGCTCCCCAAGGGGCAGCACAGATTCCCTTAACCAAGGTGCT
  TCTCCTGGGGGGCTGCTGGACCCGGCCTGCCAGAAGACGGACCATTTCCTGTCCTGCTACCCCTGGTTCC
  ACGGCCCCATCTCCAGAGTGAAAGCAGCTCAGCTGGTTCAGCTGCAGGGCCCTGATGCTCATGGAGTGTT
  CCTGGTGCGGCAGAGCGAGACGCGGCGTGGGGAATACGTGCTCACTTTCAACTTTCAGGGGATAGCCAAG
  CACCTGCGCCTGTCGCTGACAGAGCGGGGCCAGTGCCGTGTGCAGCACCTCCACTTTCCCTCGGTCGTGG
  ACATGCTCCACCACTTCCAGCGCTCGCCCATCCCACTCGAGTGCGGCGCCGCCTGTGATGTCCGGCTCTC
  CAGCTACGTGGTAGTCGTCTCCCAACCACCAGGTTCCTGCAACACGGTCCTCTTCCCTTTCTCCCTTCCT
  CACTGGGATTCAGAGTCCCTTCCTCACTGGGGTTCAGAGTTGGGCCTTCCCCACCTTAGTTCTTCTGGCT
  GTCCCCGGGGGCTCAGCCCAGAGGGTCTCCCAGGGCGATCCTCACCCCCCGAGCAGATCTTCCACCTGGT
  GCCTTCGCCCGAAGAACTGGCCAACAGCCTGCAGCACCTGGAGCATGAGCCTGTGAATCGAGCCCGGGAC
  TCGGACTACGAAATGGACTCATCCTCCCGGAGCCACCTGCGGGCCATAGACAATCAGTACACACCTCTCT
  GA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001291424
• ORF Size: 1122 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001291424.1, NP_001278353.1
• RefSeq Size: 4500
• RefSeq ORF: 1122
• Locus ID: 10019
• Protein Pathways: Neurotrophin signaling pathway
• Gene Summary: This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
  Transcript Variant: This variant (2) lacks two alternate exons in the 5' region, including a portion of the 5' coding region, and initiates translation at an alternate start codon in an alternate exon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.