Myotilin (MYOT) (NM_001300911) Human Untagged Clone

CAT#: SC335764

MYOT (untagged) - Human myotilin (MYOT), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MYOT
• Synonyms: LGMD1; LGMD1A; MFM3; TTID; TTOD
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001300911, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGATTCCAACTATCAACAGTCCTCAGCTGGCCAACCTATAAATGCAAAGCCATCCCAAACTGCAAATG
  CTAAGCCCATACCAAGAACTCCTGATCATGAAATACAAGGATCAAAAGAAGCTTTGATTCAAGATTTGGA
  AAGAAAGCTGAAATGCAAGGACACCCTTCTTCATAATGGAAATCAACGTCTAACATATGAAGAGAAGATG
  GCTCGCAGATTGCTAGGACCACAGAATGCAGCTGCTGTGTTTCAAGCTCAGGATGACAGTGGTGCACAAG
  ACTCGCAGCAACACAACTCAGAACATGCGCGACTGCAAGTTCCTACATCACAAGTAAGAAGTAGATCAAC
  CTCAAGGGGAGATGTGAATGATCAGGATGCAATCCAGGAGAAATTTTACCCACCACGTTTCATTCAAGTG
  CCAGAGAACATGTCGATTGATGAAGGAAGATTCTGCAGAATGGACTTCAAAGTGAGTGGACTGCCAGCTC
  CTGATGTGTCATGGTATCTAAATGGAAGAACAGTTCAATCAGATGATTTGCACAAAATGATAGTGTCTGA
  GAAGGGTCTTCATTCACTCATCTTTGAAGTAGTCAGAGCTTCAGATGCAGGGGCTTATGCATGTGTTGCC
  AAGAATAGAGCAGGAGAAGCCACCTTCACTGTGCAGCTGGATGTCCTTGCAAAAGAACATAAAAGAGCAC
  CAATGTTTATCTACAAACCACAGAGCAAAAAAGTTTTAGAGGGAGATTCAGTGAAACTAGAATGCCAGAT
  CTCGGCTATACCTCCACCAAAGCTTTTCTGGAAAAGAAATAATGAAATGGTACAATTCAACACTGACCGA
  ATAAGCTTATATCAAGATAACACTGGAAGAGTTACTTTACTGATAAAAGATGTAAACAAGAAAGATGCTG
  GGTGGTATACTGTGTCAGCAGTTAATGAAGCTGGAGTGACTACATGTAACACAAGATTAGACGTTACGGC
  ACGTCCAAACCAAACTCTTCCAGCTCCTAAGCAGTTACGGGTTCGACCAACATTCAGCAAATATTTAGCA
  CTTAATGGGAAAGGTTTGAATGTAAAACAAGCTTTTAACCCAGAAGGAGAATTTCAGCGTTTGGCAGCTC
  AATCTGGACTCTATGAAAGTGAAGAACTTTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001300911
• ORF Size: 1152 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001300911.1, NP_001287840.1
• RefSeq Size: 1939
• RefSeq ORF: 1152
• Locus ID: 9499
• Gene Summary: This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2008]
  Transcript Variant: This variant (3) lacks an internal segment in the 5' region, which results in translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a.