ATG4D (NM_001281504) Human Untagged Clone

CAT#: SC335944

ATG4D (untagged) - Human autophagy related 4D, cysteine peptidase (ATG4D), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ATG4D
• Synonyms: APG4-D; APG4D; AUTL4
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001281504, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCAAGTGCTTCATCTCGCTGGGCGCTGCCCCTACGTCTCCCCAGGTTGGGTGGTTAAAAGCCGGACCA
  GCTTTAGCAAGATCTCCAGCATCCACCTCTGTGGCCGCCGCTACCGTTTCGAGGGCGAGGGTGACATACA
  GCGTTTCCAGCGGGACTTTGTGTCCCGCCTGTGGCTCACATACCGCCGGGACTTCCCGCCCCTTCCTGGG
  GGCTGCCTGACCTCGGACTGTGGCTGGGGGTGCATGTTACGCAGCGGCCAGATGATGCTGGCACAGGGCC
  TTCTGCTGCATTTCCTGCCCAGAGACTGGACATGGGCCGAGGGCATGGGCCTGGGCCCCCCTGAGCTGTC
  AGGGTCAGCCTCTCCCAGCCGGTACCATGGGCCTGCCCGCTGGATGCCCCCACGCTGGGCCCAGGGTGCC
  CCTGAGCTGGAGCAGGAACGCCGGCACCGGCAGATTGTGTCCTGGTTCGCCGACCACCCCCGGGCCCCCT
  TTGGCCTACACCGGCTGGTGGAGCTTGGGCAGAGCTCAGGCAAGAAGGCAGGTGACTGGTATGGGCCATC
  GCTAGTGGCACACATCCTCAGGAAAGCCGTGGAGAGCTGCTCCGACGTCACCCGCCTGGTGGTGTACGTT
  TCTCAGGACTGCACAGTGTACAAGGCGGATGTGGCACGCCTGGTGGCCAGGCCAGACCCCACAGCCGAGT
  GGAAGTCTGTGGTCATCCTGGTGCCCGTGCGACTGGGTGGCGAGACTCTCAACCCCGTGTATGTGCCCTG
  CGTGAAGGAACTCCTGCGTTGCGAGCTGTGCCTGGGCATCATGGGTGGGAAACCGCGACACTCACTGTAC
  TTCATTGGCTACCAAGATGACTTCCTGCTGTACCTGGACCCTCACTACTGCCAGCCCACTGTGGATGTCA
  GCCAGGCCGACTTCCCCCTGGAGTCCTTCCACTGCACCTCGCCCCGCAAGATGGCCTTTGCCAAGATGGA
  CCCAAGCTGTACCGTGGGCTTCTATGCTGGAGACAGGAAGGAGTTTGAGACACTCTGCTCAGAGCTGACC
  AGGGTCCTCAGCTCCTCCTCAGCCACAGAGCGGTACCCCATGTTCACCCTGGCCGAGGGCCATGCTCAGG
  ACCACAGCCTGGACGACCTCTGCTCCCAGCTCGCCCAGCCCACACTCCGGCTCCCTCGCACAGGGCGGCT
  CCTCAGGGCCAAACGCCCCAGCTCTGAGGACTTTGTGTTTTTATAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001281504
• ORF Size: 1236 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001281504.1, NP_001268433.1
• RefSeq Size: 2070
• RefSeq ORF: 1236
• Locus ID: 84971
• Protein Pathways: Regulation of autophagy
• Gene Summary: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.