RIC8 (RIC8A) (NM_001286134) Human Untagged Clone

CAT#: SC336638

RIC8A (untagged) - Human RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RIC8A
• Synonyms: RIC8
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001286134, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAGCCCCGGGCGGTTGCAGAAGCCGTGGAGACGGGTGAGGAGGATGTGATTATGGAAGCTCTGCGGT
  CATACAACCAGGAGCACTCCCAGAGCTTCACGTTTGATGATGCCCAACAGGAGGACCGGAAGAGACTGGC
  GGAGCTGCTGGTCTCCGTCCTGGAACAGGGCTTGCCACCCTCCCACCGTGTCATCTGGCTGCAGAGTGTC
  CGAATCCTGTCCCGGGACCGCAACTGCCTGGACCCGTTCACCAGCCGCCAGAGCCTGCAGGCACTAGCCT
  GCTATGCTGACATCTCTGTCTCTGAGGGGTCCGTCCCAGAGTCCGCAGACATGGATGTTGTACTGGAGTC
  CCTCAAGTGCCTGTGCAACCTCGTGCTCAGCAGCCCTGTGGCACAGATGCTGGCAGCAGAGGCCCGCCTA
  GTGGTGAAGCTCACAGAGCGTGTGGGGCTGTACCGTGAGAGGAGCTTCCCCCACGATGTCCAGTTCTTTG
  ACTTGCGGCTCCTCTTCCTGCTAACGGCACTCCGCACCGATGTGCGCCAGCAGCTGTTTCAGGAGCTGAA
  AGGAGTGCGCCTGCTAACTGACACACTGGAGCTGACGCTGGGGGTGACTCCTGAAGGGAACCCCCCACCC
  ACGCTCCTTCCTTCCCAAGAGACTGAGCGGGCCATGGAGATCCTCAAAGTGCTCTTCAACATCACCCTGG
  ACTCCATCAAGGGGGAGGTGGACGAGGAAGACGCTGCCCTTTACCGACACCTGGGGACCCTTCTCCGGCA
  CTGTGTGATGATCGCTACTGCTGGAGACCGCACAGAGGAGTTCCACGGCCACGCAGTGAACCTCCTGGGG
  AACTTGCCCCTCAAGTGTCTGGATGTTCTCCTCACCCTGGAGCCACATGGAGACTCCACGGAGTTCATGG
  GAGTGAATATGGATGTGATTCGTGCCCTCCTCATCTTCCTAGAGAAGCGTTTGCACAAGACACACAGGCT
  GAAGGAGAGTGTAGCTCCCGTGCTGAGCGTGCTGACTGAATGTGCCCGGATGCACCGCCCAGCCAGGAAG
  TTCCTGAAGGCCCAGGTGCTGCCCCCTCTGCGGGATGTGAGGACACGGCCTGAGGTTGGGGAGATGCTGC
  GGAACAAGCTTGTCCGCCTCATGACACACCTGGACACAGATGTGAAGAGGGTGGCTGCCGAGTTCTTGTT
  TGTCCTGTGCTCTGAGAGTGTGCCCCGATTCATCAAGTACACAGGCTATGGGAATGCTGCTGGCCTTCTG
  GCTGCCAGGGGCCTCATGGCAGGAGGCCGGCCCGAGGGCCAGTACTCAGAGGATGAGGACACAGACACAG
  ATGAGTACAAGGAAGCCAAAGCCAGCATAAACCCTGTGACCGGGAGGGTGGAGGAGAAGCCGCCTAACCC
  TATGGAGGGCATGACAGAGGAGCAGAAGGAGCACGAGGCCATGAAGCTGGTGACCATGTTTGACAAGCTC
  TCCAGGAACAGAGTCATCCAGCCAATGGGGATGAGTCCCCGGGGTCATCTTACGTCCCTGCAGGATGCCA
  TGTGCGAGACTATGGAGCAGCAGCTCTCCTCGGACCCTGACTCGGACCCTGACTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001286134
• ORF Size: 1596 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001286134.1, NP_001273063.1
• RefSeq Size: 3765
• RefSeq ORF: 1596
• Locus ID: 60626
• Gene Summary: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.