STAT5A (NM_001288719) Human Untagged Clone

CAT#: SC337408

STAT5A (untagged) - Human signal transducer and activator of transcription 5A (STAT5A), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: STAT5A
• Synonyms: MGF; STAT5
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001288719, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCGGGCTGGATCCAGGCCCAGCAGCTGCAGGGAGACGCGCTGCGCCAGATGCAGGTGCTGTACGGCC
  AGCACTTCCCCATCGAGGTCCGGCACTACTTGGCCCAGTGGATTGAGAGCCAGCCATGGGATGCCATTGA
  CTTGGACAATCCCCAGGACAGAGCCCAAGCCACCCAGCTCCTGGAGGGCCTGGTGCAGGAGCTGCAGAAG
  AAGGCGGAGCACCAGGTGGGGGAAGATGGGTTTTTACTGAAGATCAAGCTGGGGCACTACGCCACGCAGC
  TCCAGTGCAGCTCTCCGGCTGGGATCCTGGTTGACGCCATGTCCCAGAAGCACCTTCAGATCAACCAGAC
  ATTTGAGGAGCTGCGACTGGTCACGCAGGACACAGAGAATGAGCTGAAGAAACTGCAGCAGACTCAGGAG
  TACTTCATCATCCAGTACCAGGAGAGCCTGAGGATCCAAGCTCAGTTTGCCCAGCTGGCCCAGCTGAGCC
  CCCAGGAGCGTCTGAGCCGGGAGACGGCCCTCCAGCAGAAGCAGGTGTCTCTGGAGGCCTGGTTGCAGCG
  TGAGGCACAGACACTGCAGCAGTACCGCGTGGAGCTGGCCGAGAAGCACCAGAAGACCCTGCAGCTGCTG
  CGGAAGCAGCAGACCATCATCCTGGATGACGAGCTGATCCAGTGGAAGCGGCGGCAGCAGCTGGCCGGGA
  ACGGCGGGCCCCCCGAGGGCAGCCTGGACGTGCTACAGTCCTGGTGTGAGAAGTTGGCCGAGATCATCTG
  GCAGAACCGGCAGCAGATCCGCAGGGCTGAGCACCTCTGCCAGCAGCTGCCCATCCCCGGCCCAGTGGAG
  GAGATGCTGGCCGAGGTCAACGCCACCATCACGGACATTATCTCAGCCCTGGTGACCAGCACATTCATCA
  TTGAGAAGCAGCCTCCTCAGGTCCTGAAGACCCAGACCAAGTTTGCAGCCACCGTACGCCTGCTGGTGGG
  CGGGAAGCTGAACGTGCACATGAATCCCCCCCAGGTGAAGGCCACCATCATCAGTGAGCAGCAGGCCAAG
  TCTCTGCTTAAAAATGAGAACACCCGCAACGAGTGCAGTGGTGAGATCCTGAACAACTGCTGCGTGATGG
  AGTACCACCAAGCCACGGGCACCCTCAGTGCCCACTTCAGGAACATGTCACTGAAGAGGATCAAGCGTGC
  TGACCGGCGGGGTGCAGAGTCCGTGACAGAGGAGAAGTTCACAGTCCTGTTTGAGTCTCAGTTCAGTGTT
  GGCAGCAATGAGCTTGTGTTCCAGGTGAAGACTCTGTCCCTACCTGTGGTTGTCATCGTCCACGGCAGCC
  AGGACCACAATGCCACGGCTACTGTGCTGTGGGACAATGCCTTTGCTGAGCCGGGCAGGGTGCCATTTGC
  CGTGCCTGACAAAGTGCTGTGGCCGCAGCTGTGTGAGGCGCTCAACATGAAATTCAAGGCCGAAGTGCAG
  AGCAACCGGGGCCTGACCAAGGAGAACCTCGTGTTCCTGGCGCAGAAACTGTTCAACAACAGCAGCAGCC
  ACCTGGAGGACTACAGTGGCCTGTCCGTGTCCTGGTCCCAGTTCAACAGGGAGAACTTGCCGGGCTGGAA
  CTACACCTTCTGGCAGTGGTTTGACGGGGTGATGGAGGTGTTGAAGAAGCACCACAAGCCCCACTGGAAT
  GATGGGGCCATCCTAGGTTTTGTGAATAAGCAACAGGCCCACGACCTGCTCATCAACAAGCCCGACGGGA
  CCTTCTTGTTGCGCTTTAGTGACTCAGAAATCGGGGGCATCACCATCGCCTGGAAGTTTGACTCCCCGGA
  ACGCAACCTGTGGAACCTGAAACCATTCACCACGCGGGATTTCTCCATCAGGTCCCTGGCTGACCGGCTG
  GGGGACCTGAGCTATCTCATCTATGTGTTTCCTGACCGCCCCAAGGATGAGGTCTTCTCCAAGTACTACA
  CTCCTGTGCTGGCTAAAGCTGTTGATGGATATGTGAAACCACAGATCAAGCAAGTGGTCCCTGAGTTTGT
  GAATGCATCTGCAGATGCTGGGGGCAGCAGCGCCACGTACATGGACCAGGCCCCCTCCCCAGCTGTGTGC
  CCCCAGGCTCCCTATAACATGTACCCACAGAACCCTGACCATGTACTCGATCAGGATGGAGAATTCGACC
  TGGATGAGACCATGGATGTGGCCAGGCACGTGGAGGAACTCTTACGCCGACCAATGGACAGTCTTGACTC
  CCGCCTCTCGCCCCCTGCCGGTCTTTTCACCTCTGCCAGAGGCTCCCTCTCATGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001288719
• ORF Size: 2295 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001288719.1, NP_001275648.1
• RefSeq Size: 4135
• RefSeq ORF: 2295
• Locus ID: 6776
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Chronic myeloid leukemia, ErbB signaling pathway, Jak-STAT signaling pathway, Pathways in cancer
• Gene Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
  Transcript Variant: This variant (3) lacks an in-frame coding exon in the 5' region compared to variant 1. The resulting shorter isoform (2) lacks an internal protein segment compared to isoform 1.