Dkk3 (NM_015814) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR205281L3V

Lenti ORF particles, Dkk3 (Myc-DDK-tagged) - Mouse dickkopf homolog 3 (Xenopus laevis) (Dkk3), 200ul, >10^7 TU/mL

Product Images

MR205281L3 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with MR205281L3V particle to overexpress human Dkk3-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: Dkk3
• Synonyms: AW061014; C87148; dkk-3; mDkk-3
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_015814
• ORF Size: 1050 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR205281).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_015814.2
• RefSeq Size: 3357 bp
• RefSeq ORF: 1050 bp
• Locus ID: 50781
• UniProt ID: Q9QUN9
• Cytogenetics: 7 F1
• Gene Summary: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).[UniProtKB/Swiss-Prot Function]