GNB3 (NM_002075) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200470L1V

Lenti ORF particles, GNB3 (Myc-DDK tagged) - Human guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: GNB3
• Synonyms: CSNB1H
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_002075
• ORF Size: 1020 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200470).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_002075.2, NP_002066.1
• RefSeq Size: 1760 bp
• RefSeq ORF: 1023 bp
• Locus ID: 2784
• Cytogenetics: 12p13.31
• Protein Families: Druggable Genome
• Protein Pathways: Chemokine signaling pathway, Taste transduction
• MW: 37.3 kDa
• Gene Summary: 'Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]'