PARL (NM_018622) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC204096L2V

Lenti ORF particles, PARL (mGFP-tagged) - Human presenilin associated, rhomboid-like (PARL), nuclear gene encoding mitochondrial protein, transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: PARL
• Synonyms: PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1
• Vector: pLenti-C-mGFP
• ACCN: NM_018622
• ORF Size: 1137 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC204096).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_018622.5, NP_061092.3
• RefSeq Size: 1423
• RefSeq ORF: 1140
• Locus ID: 55486
• Domains: Rhomboid
• Protein Families: Protease, Transmembrane
• MW: 42.2 kDa
• Gene Summary: This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]