beta glucuronidase (GUSB) (NM_000181) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC204325L2V

Lenti ORF particles, GUSB (mGFP-tagged) - Human glucuronidase, beta (GUSB), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: GUSB
• Synonyms: BG; MPS7
• Vector: pLenti-C-mGFP
• ACCN: NM_000181
• ORF Size: 1953 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC204325).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000181.2, NP_000172.1
• RefSeq Size: 2321 bp
• RefSeq ORF: 1956 bp
• Locus ID: 2990
• Cytogenetics: 7q11.21
• Domains: Glyco_hydro_2, Glyco_hydro_2_C, Glyco_hydro_2_N
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Drug metabolism - other enzymes, Glycosaminoglycan degradation, Lysosome, Metabolic pathways, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Starch and sucrose metabolism
• MW: 74.7 kDa
• Gene Summary: 'This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]'