Collagen I (COL1A1) (NM_000088) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC206234L2V
- LentiORF®
Lenti ORF particles, COL1A1 (mGFP-tagged) - Human collagen, type I, alpha 1 (COL1A1), 200ul, >10^7 TU/mL
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Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | mGFP |
Symbol | COL1A1 |
Synonyms | CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4 |
Vector | pLenti-C-mGFP |
ACCN | NM_000088 |
ORF Size | 4392 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC206234).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_000088.3, NP_000079.2 |
RefSeq Size | 5927 bp |
RefSeq ORF | 4395 bp |
Locus ID | 1277 |
Cytogenetics | 17q21.33 |
Domains | COLFI, VWC, Collagen |
Protein Families | Druggable Genome |
Protein Pathways | ECM-receptor interaction, Focal adhesion |
MW | 139.01 kDa |
Gene Summary | 'This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]' |
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