Estrogen Receptor 1 (ESR1) (NM_000125) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC213277L3V

Lenti ORF particles, ESR1 (Myc-DDK tagged) - Human estrogen receptor 1 (ESR1), transcript variant 1, 200ul, >10^7 TU/mL

Product Images

RC213277L3 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC213277L3V particle to overexpress human ESR1-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: ESR1
• Synonyms: ER; Era; ESR; ESRA; ESTRR; NR3A1
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_000125
• ORF Size: 1785 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC213277).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000125.2, NP_000116.2
• RefSeq Size: 6456 bp
• RefSeq ORF: 1788 bp
• Locus ID: 2099
• UniProt ID: P03372, G4XH65
• Cytogenetics: 6q25.1-q25.2
• Domains: HOLI, Oest_recep, zf-C4
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• MW: 66 kDa
• Gene Summary: 'This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. [provided by RefSeq, Jul 2020]'