MTR (NM_000254) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC214275L2V

Lenti ORF particles, MTR (mGFP-tagged)-Human 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: MTR
• Synonyms: cblG; HMAG; MS
• Vector: pLenti-C-mGFP
• ACCN: NM_000254
• ORF Size: 3795 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC214275).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000254.1, NP_000245.1
• RefSeq Size: 7122 bp
• RefSeq ORF: 3798 bp
• Locus ID: 4548
• Cytogenetics: 1q43
• Domains: Pterin_bind, S-methyl_trans, B12-binding_2, Met_synt_B12, B12-binding
• Protein Families: Druggable Genome
• Protein Pathways: Cysteine and methionine metabolism, Metabolic pathways, One carbon pool by folate
• MW: 140.3 kDa
• Gene Summary: 'This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]'