TLR5 (NM_003268) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC215293L2V

Lenti ORF particles, TLR5 (mGFP-tagged) - Human toll-like receptor 5 (TLR5), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: TLR5
• Synonyms: MELIOS; SLE1; SLEB1; TIL3
• Vector: pLenti-C-mGFP
• ACCN: NM_003268
• ORF Size: 2574 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC215293).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_003268.3, NP_003259.2
• RefSeq Size: 3369 bp
• RefSeq ORF: 2577 bp
• Locus ID: 7100
• Cytogenetics: 1q41
• Domains: TIR, LRRCT, LRR, LRR_TYP, LRR_SD22, LRR_PS
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway
• MW: 97.77 kDa
• Gene Summary: 'This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]'