IGF2R (NM_000876) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC215594L1V

Lenti ORF particles, IGF2R (Myc-DDK tagged) - Human insulin-like growth factor 2 receptor (IGF2R), 200ul, >10^7 TU/mL

Product Images

RC215594L1 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC215594L1V particle to overexpress human IGF2R-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: IGF2R
• Synonyms: CD222; CI-M6PR; CIMPR; M6P-R; M6P/IGF2R; MPR1; MPR 300; MPR300; MPRI
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_000876
• ORF Size: 7473 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC215594).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000876.1, NP_000867.1
• RefSeq Size: 9090 bp
• RefSeq ORF: 7476 bp
• Locus ID: 3482
• UniProt ID: P11717
• Cytogenetics: 6q25.3
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Lysosome
• MW: 274.26 kDa
• Gene Summary: 'This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]'