Human alpha 1 Antichymotrypsin (SERPINA3) activation kit by CRISPRa

CAT#: GA100005

SERPINA3 CRISPRa kit - CRISPR gene activation of human serpin family A member 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SERPINA3
• Locus ID: 12
• Kit Components:

  GA100005G1, alpha 1 Antichymotrypsin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100005G2, alpha 1 Antichymotrypsin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100005G3, alpha 1 Antichymotrypsin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001085
• Synonyms: AACT; ACT; GIG24; GIG25
• Summary: 'The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jun 2020]'