Human ABL2 activation kit by CRISPRa

CAT#: GA100019

ABL2 CRISPRa kit - CRISPR gene activation of human ABL proto-oncogene 2, non-receptor tyrosine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ABL2
• Locus ID: 27
• Kit Components:

  GA100019G1, ABL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100019G2, ABL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100019G3, ABL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001100108, NM_001136000, NM_001136001, NM_001168236, NM_001168237, NM_001168238, NM_001168239, NM_005158, NM_007314
• Synonyms: ABLL; ARG; FLJ22224; FLJ31718; FLJ41441
• Summary: 'This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]'