Human ACOX1 activation kit by CRISPRa

CAT#: GA100039

ACOX1 CRISPRa kit - CRISPR gene activation of human acyl-CoA oxidase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ACOX1
• Locus ID: 51
• Kit Components:

  GA100039G1, ACOX1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100039G2, ACOX1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100039G3, ACOX1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001185039, NM_004035, NM_007292
• Synonyms: ACOX; PALMCOX; SCOX
• Summary: 'The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]'