Human gamma Actin (ACTG1) activation kit by CRISPRa

CAT#: GA100049

ACTG1 CRISPRa kit - CRISPR gene activation of human actin gamma 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ACTG1
• Locus ID: 71
• Kit Components:

  GA100049G1, gamma Actin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100049G2, gamma Actin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100049G3, gamma Actin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199954, NM_001614, NR_037688
• Synonyms: ACT; ACTG; BRWS2; DFNA20; DFNA26; HEL-176
• Summary: 'Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]'