Human Adenylosuccinate Lyase (ADSL) activation kit by CRISPRa
CAT#: GA100111
ADSL CRISPRa kit - CRISPR gene activation of human adenylosuccinate lyase
Find the corresponding CRISPRi Inhibitor Kit
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 3gRNAs, 1 scramble ctrl and 1 enhancer vector |
Symbol | ADSL |
Locus ID | 158 |
Kit Components | GA100111G1, Adenylosuccinate Lyase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100111G2, Adenylosuccinate Lyase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100111G3, Adenylosuccinate Lyase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_000026, NM_001123378, NM_001317923, NR_134256, NM_001363840 |
Synonyms | AMPS; ASASE; ASL |
Summary | 'The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]' |
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Other Versions
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KN400524 | ADSL - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
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