Human S adenosylhomocysteine hydrolase (AHCY) activation kit by CRISPRa

CAT#: GA100135

AHCY CRISPRa kit - CRISPR gene activation of human adenosylhomocysteinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AHCY
• Locus ID: 191
• Kit Components:

  GA100135G1, S adenosylhomocysteine hydrolase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100135G2, S adenosylhomocysteine hydrolase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100135G3, S adenosylhomocysteine hydrolase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000687, NM_001161766, NM_001322084, NM_001322085, NM_001322086, NM_001362750
• Synonyms: adoHcyase; SAHH
• Summary: 'S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]'