Human ALDH3A1 activation kit by CRISPRa

CAT#: GA100153

ALDH3A1 CRISPRa kit - CRISPR gene activation of human aldehyde dehydrogenase 3 family member A1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ALDH3A1
• Locus ID: 218
• Kit Components:

  GA100153G1, ALDH3A1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100153G2, ALDH3A1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100153G3, ALDH3A1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000691, NM_001135167, NM_001135168, NM_001330150
• Synonyms: ALDH3; ALDHIII
• Summary: 'Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]'