Human Aldolase (ALDOA) activation kit by CRISPRa

CAT#: GA100161

ALDOA CRISPRa kit - CRISPR gene activation of human aldolase, fructose-bisphosphate A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ALDOA
• Locus ID: 226
• Kit Components:

  GA100161G1, Aldolase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100161G2, Aldolase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100161G3, Aldolase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000034, NM_001127617, NM_001243177, NM_184041, NM_184043, NM_001355562, NM_001355563, NM_001355564, NM_001355565, NM_001243175
• Synonyms: ALDA; GSD12; HEL-S-87p
• Summary: 'This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]'