Human 12 Lipoxygenase (ALOX12) activation kit by CRISPRa

CAT#: GA100166

ALOX12 CRISPRa kit - CRISPR gene activation of human arachidonate 12-lipoxygenase, 12S type

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ALOX12
• Locus ID: 239
• Kit Components:

  GA100166G1, 12 Lipoxygenase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100166G2, 12 Lipoxygenase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100166G3, 12 Lipoxygenase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000697
• Synonyms: 12-LOX; 12S-LOX; LOG12
• Summary: 'This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]'